DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and rcbtb1

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_956285.1	Gene:	rcbtb1 / 336007	ZFINID:	ZDB-GENE-030131-7951	Length:	531	Species:	Danio rerio

Alignment Length:	357	Identity:	70/357 - (19%)
Similarity:	125/357 - (35%)	Gaps:	116/357 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 AGGELLLLTTDHALYSAKLQANR-------------EHMDLQLLRTDVVDMDFCSGSQELFVVLT 101
            :..|.:.:|.|..:|...|..:.             :.:|. |....::.:.:.||...|.|.
Zfish    30 SANEAIYITHDDEVYVLGLNCSNCLGTGDSQSTIAPKKLDC-LSGKKLISLSYGSGPHVLLVT-- 91

  Fly   102 NGSVQRQATGSGRDVGHPHAWQTLGFDPL--------------ELHAEGVRIRRVCCSAQGVVFV 152
                         :.|..:||...|:..|              ..:.:|.|:..|.|.:...:.:
Zfish    92 -------------EDGELYAWGHNGYSQLGNGTTNQGVSPILVSTNLQGKRVTEVSCGSHHSLAL 143

  Fly   153 GASGETYVMG--SCGEVFKA----EQQPRHMRLYEEGKELLDLAAGNEHFVMLVAPYNLADDALQ 211
            ...||.:..|  :||:|...    :..||.:....:.|.::::|.|
Zfish   144 THEGEVFAWGYNNCGQVGSGSTANQPTPRKVSNCLQNKVIVNIACG------------------- 189

  Fly   212 LSVASAKEEPEDERASVKSISSGHSERSVAANTRHLLHQGYALLHTQLFTFGASNNGLLGSGDHI 276
                        :.:|:....:|                       :::.:|.:.||.||.|::.
Zfish   190 ------------QTSSMAVTDNG-----------------------EVYGWGYNGNGQLGLGNNG 219

  Fly   277 RRANVMRLQKLDSMGVCSIAAGLEHTVARTLDGRLYHWGLNNHSQLG----EDVSSPMEITITEN 337
            .:....||..|....|..||:|..|::|.|.:|.||.||.|.:.|||    .:..||::: :||.
Zfish   220 NQLTPCRLIALQGFCVLQIASGYAHSLALTDEGLLYAWGANTYGQLGTGNKSNQLSPVQV-MTEK 283

  Fly   338 TAALPIEQNSALEATCGDYHTLLLNA-SGQIH 368
            ...:.|       |.|...||..... |||::
Zfish   284 ERIVEI-------AACHSTHTSAAKTQSGQVY 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	14/45 (31%)
		RCC1_2	292..321	CDD:290274	13/28 (46%)
		RCC1	308..361	CDD:278826	18/56 (32%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
rcbtb1	NP_956285.1	RCC1	40..90	CDD:278826	8/50 (16%)
		RCC1_2	77..106	CDD:290274	8/43 (19%)
		RCC1	93..143	CDD:278826	9/49 (18%)
		RCC1	146..196	CDD:278826	12/80 (15%)
		RCC1	199..248	CDD:278826	15/71 (21%)
		RCC1	251..299	CDD:278826	18/55 (33%)
		BTB	360..464	CDD:279045
		BTB	371..467	CDD:197585
		SPOP_C_like	467..525	CDD:269810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900