DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Als2 and Als2cl

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	XP_006244073.1	Gene:	Als2cl / 316017	RGDID:	1305208	Length:	952	Species:	Rattus norvegicus

Alignment Length:	1132	Identity:	263/1132 - (23%)
Similarity:	427/1132 - (37%)	Gaps:	334/1132 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   434 LQLLLKHRQAVQTLEIWQRQSALEPLSAL-GPLLINWERILCLLVATLHSLEGFYRADFVQPADL 497
            |:||.:..::.|.|.....||.|.....| .|..::.|.:|.|           ..||:|..|
  Rat    47 LRLLQQLHESAQRLWDVTEQSLLSLRQRLYHPPSMSLEAVLLL-----------NNADYVLQA-- 98

  Fly   498 LFICHYKEYIDLFDGYTKAYCDVFSVNGF--------------GEAVVAITGLSSPLAELNEESY 548
                 :.|||       |:|.|...|..|              .:|:..:  |||..:|.:..:.
  Rat    99 -----HMEYI-------KSYTDCLVVQAFQKVSKKRSEFWRSQRKALRQL--LSSGSSEGSVGTT 149

  Fly   549 VTRLFQQPFSIYQLFVQ-FMELLVRTQSEYGEHRVAWSEFARH---------SCISQEL--AVNT 601
            :.:..:||.:.:   || ::.||:..:....||..| .:...|         |.:.|.|  |:.|
  Rat   150 LCQALRQPLAHH---VQKYVLLLLSLRDTLDEHHPA-QQLVMHAVTLFGNLQSFMQQALDQAMAT 210

  Fly   602 KDFWSSNDRNPRIVQFRGRHRRVILTSALVPLKLVTSGISRSSNSFILFSDFLCQVSGNSLYSYP 666
            :..|.|.....|.|.....| |::..|..:|:.:......|    .:||.|.|..:.|::::::.
  Rat   211 QALWHSLSSRLRDVLCTPTH-RLLQDSQDIPVVVTPLRAER----VLLFDDTLVLLQGHNVHTFD 270

  Fly   667 LTTLWVWTEGDS--LRLTTPEKSFLVSTRSQEMRKVWLDQLQSSIIASL-GKP----LGS----- 719
            |..:||....|.  |.:.|||..|...||..:.:.||..::..::..:| ||.    |||
  Rat   271 LKLVWVDPSQDKCVLHILTPEDEFSFCTRDPQGQVVWQWKVTQAVCQALCGKKDFPVLGSGREPS 335

  Fly   720 -PVPSYRSTGYEFSREHPKFSRVKACGTWRKGVLHGNCYLEYPDGSVYCGELQHGIIEGFGKMVI 783
             | |..|...|.|.|| .:..:....|.|.:...||...|::|||..:.|:...|:..|||..::
  Rat   336 VP-PECRCLAYTFHRE-GRLYQATYDGEWSRAKPHGKGTLKWPDGRNHVGDFYQGLEHGFGICLV 398

  Fly   784 PTTG-----LYVGNFKGGRFHGHGVYEMHCKDSPESEVYEGNFCEGLFHGHGVMRN-----NRYI 838
            |...     .|..:::.||...:|:.|.     ...|||:|.|..|:.||.||:.:     ..:.
  Rat   399 PQASEDKFDCYKCHWREGRMCEYGICEY-----GTDEVYKGYFQAGVRHGFGVLDSAPQAPQPFR 458

  Fly   839 YVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITNRGDYFEGSFSGDDLTGSGVAVF 903
            |.|.::...|||||:.||...|::|:||:..::|.|.|..:|..|..::|:|.||.:.|.|:.:.
  Rat   459 YTGHWERGQRSGYGIEEDRDRGERYIGMWQADQRHGPGIVVTQAGVCYQGTFQGDKMAGPGILLC 523

  Fly   904 ENDYYYEG----ELTLLGPNGRGEYYMPSGDACGGSGAMGTGEFDDTCELIGNKMFGQLSGTWDT 964
            |:|..|||    |||||   |:|:...|:|....||...||.:          .::.|  |..||
  Rat   524 EDDSLYEGTFTRELTLL---GKGKVTFPNGFTLEGSFCSGTDK----------GLYTQ--GVLDT 573

  Fly   965 VRIQAGELVLNRRFPKYPSS-----LGRQVVDHNRKWRSLFNNFESDLANCTASTSSSGGNQSAG 1024
            ..:           |..|||     ||........:|:.:::.|.
  Rat   574 TAL-----------PPNPSSTRKRQLGLGAFPVESRWQGVYSPFR-------------------- 607

  Fly  1025 TLRKSSKPTLSTAQIWNCIAVYMSKQRAREGTKPGNYFNNILLSLPLPQKTSSPLAKARTTTSAL 1089

  Rat   608 ----------------------------------------------------------------- 607

  Fly  1090 SKLQTEAASALDFLGFPPRRIQSQEALNSKPGGLQRADSLISMGHNTSRDLDNSSLASFQLDQSL 1154
                       |||..            ..||.||.|  |:.....:||:|..|
  Rat   608 -----------DFLRL------------GCPGELQEA--LLGFHVQSSRELRKS----------- 636

  Fly  1155 MNSTVNGDESSTFNESFSKLSHNNNNSISKHMNNIDCSITSTTSTTSAVLDQVPSFGMALVLTEQ 1219
                   .|......|..|                ||     ..:...:|.:        :|..:
  Rat   637 -------QEYLCCERSHPK----------------DC-----VGSMEDILKE--------LLQHR 665

  Fly  1220 DVTSIRLYLEQAFKDRHHPLYVLNERIANCFHYSY-GYWKVKPTPILA----KQAMRE-WESISR 1278
            ...:::.||.:|..:..|||..|.:.:...|..:| |....|....:|    ||..|| |.:
  Rat   666 KPKALQQYLRKALSNSRHPLGKLLQTLMLTFQATYSGIGANKHLQAMAQEEVKQHARELWAA--- 727

  Fly  1279 RIYRFVRKMF-----PALPEELCQMEGSREVISHITLLYPLVLSEGIYSTLFVLYANKYSRKDEM 1338
              ||.:.|:.     ..|.||  .|| :|::..| .||.||:| ...||.||.||...:.|:|.:
  Rat   728 --YRGLLKVALLRQGQTLEEE--SME-TRDLQVH-GLLLPLLL-PSFYSELFTLYLLLHEREDGL 785

  Fly  1339 YRQNLNLAEKLKDQELVELMGHESFL-------------HNVMLDPKFVESVQTLKELQEKFSPQ 1390
            |.:.:.......|.:|:|.:..:..|             ::::.|..|:.:.:.|:::.....|:
  Rat   786 YSRGIANLSLFPDTKLLEFLDVQKHLWPLKDLRLTSNQRYSLVRDKCFLSATECLQKIITTVDPR 850

  Fly  1391 DMLTVIQRSTQLLTEAYEHAMAANAAQLNADNMIPLTMLTMLRAAVPHLGAELALLDDL-----T 1450
            :.|.|::: |....||....:.....:|..|:::||.:..:.||.:.|||||:.|:.|:     |
  Rat   851 EKLEVLEK-TYGEIEATVSRVLGREYKLPMDDLLPLLIYVVSRARIQHLGAEIHLIRDMMDPIHT 914

  Fly  1451 GGPNFQAEMNGMAGYCYTTLKAAYEHV 1477
            |         |:..:..|.|::.|||:
  Rat   915 G---------GLHDFLLTALESCYEHI 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622	24/101 (24%)
		VPS9	1373..1479	CDD:280383	29/110 (26%)
Als2cl	XP_006244073.1	PH-like	223..321	CDD:418428	25/102 (25%)
		PLN03185	357..>550	CDD:215619	66/200 (33%)
		VPS9	835..937	CDD:388595	28/108 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11303
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2642
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D25604at33208
OrthoFinder	1	1.000	-	-		FOG0002992
OrthoInspector	1	1.000	-	-		otm46008
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46089
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.930