DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and Jph3

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001100907.1	Gene:	Jph3 / 307916	RGDID:	1308416	Length:	749	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	114/511 - (22%)
Similarity:	172/511 - (33%)	Gaps:	161/511 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   760 YPDGSVYCGELQHGIIEGFGKMVIPT-TGLYVGNFKGGRFHGHGVYEMHCKDSPESEVYEGNFCE 823
            :.||..|||..:.|...|.|....|. .|.|.|::..| |...|||..     |....|:|.:.:
  Rat     9 FDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHG-FEVLGVYTW-----PSGNTYQGTWAQ 67

  Fly   824 GLFHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITNRGDYFEG 888
            |..||.|:....:::|.||:....:..|||.|...:|.||.|.:::..:.|.|:...:.|..::|
  Rat    68 GKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECTGNGAKYEGTWSNGLQDGYGTETYSDGGTYQG 132

  Fly   889 SFSGDDLTGSGVAVFENDYYYEGELTLLGP-------------NGRGEYYMPSGDACGGSGAMGT 940
            .:.|....|.||   .....|.....:..|             || ...:..:..|..||.|:..
  Rat   133 QWVGGMRQGYGV---RQSVPYGMAAVIRSPLRTSINSLRSEHTNG-AALHPDASPAVAGSPAVSR 193

  Fly   941 GEF----DDTCELIGNKMFG-----QLSGTWDTVRIQAGELVLNRRFPKYPSSLGRQVVDHNRKW 996
            |.|    ....|::.:|..|     .|||             |..|..:..|||..|
  Rat   194 GGFVLVAHSDSEILKSKKKGLFRRSLLSG-------------LKLRKSESKSSLASQ-------- 237

  Fly   997 RSLFNNFESDLANCTASTSSS------------------------------------------GG 1019
            ||..::|.|:....|.|:::|                                          |.
  Rat   238 RSKQSSFRSEAGMSTVSSTASDIHSTISLGEAEAELAVIEDDIDATTTETYVGEWKNDKRSGFGV 302

  Fly  1020 NQSAGTLRKSSKPTLSTAQIWNCIAVYMSKQRAREGTK-PGNYFNNILLS------LPL------ 1071
            :|.:..|:...:...:....:.|:..       .:||| .|.|..|:|:|      :||
  Rat   303 SQRSDGLKYEGEWVSNRRHGYGCMTF-------PDGTKEEGKYKQNVLVSGKRKNLIPLRASKIR 360

  Fly  1072 ------------------------PQKTSSPLAKARTTTSALSKLQTEA----ASALDFL----- 1103
                                    ..:||...|||....:|..|.|.||    .:|.:|.
  Rat   361 EKVDRAVEAAERAATIAKQKAEIAASRTSHSRAKAEAALTAAQKAQEEARIARITAKEFSPSFQH 425

  Fly  1104 ---GFPPRRIQSQ------EALNSKPGGLQRADSLISMGHNTSRDL--DNSSLASF 1148
               |...:|.:.|      |.|::.....|.:..|...| .|..||  |:|.|.||
  Rat   426 RENGLEYQRPKHQMSCDDIEVLSTGTPLQQESPELYRKG-TTPSDLTPDDSPLQSF 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
Jph3	NP_001100907.1	MORN	15..35	CDD:280628	7/19 (37%)
		MORN	107..129	CDD:280628	5/21 (24%)
		MORN	311..333	CDD:280628	2/28 (7%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900