Protein Alignment Als2 and Jph1

DIOPT Version :9

• Sequence 1: NP_649347.1
• Gene: Als2 / 40410
• FlyBaseID: FBgn0037116
• Length: 1486
• Species: Drosophila melanogaster
• Sequence 2: NP_001100100.1
• Gene: Jph1 / 297748
• RGDID: 1308789
• Length: 660
• Species: Rattus norvegicus
• Alignment Length: 617
• Identity: 118/617 - (19%)
• Similarity: 199/617 - (32%)
• Gaps: 176/617 - (28%)

  Fly   759 EYPDGSVYCGELQHGIIEGFGKMVIPT-TGLYVGNFKGGRFHGHGVYEMHCKDSPESEVYEGNFC 822
            ::.||..|||..:.|...|.|....|. .|.|.|::..| |...|.|..     |....|:|.:.
  Rat     7 DFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHG-FEVVGGYTW-----PSGNTYQGYWA 65

  Fly   823 EGLFHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITNRGDYFE 887
            :|..||.||....:::|.||:....:..|||.:.|.:..:|.|.:::..:.|.|......|..::
  Rat    66 QGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQ 130

  Fly   888 GSFSGDDLTGSGVAVFENDYYYEGELTLLGP-------------NGRGEYYMPSGDACGGSGAMG 939
            |.::|....|.||   .....|.....:..|             ||...:...:..|...:|..|
  Rat   131 GQWAGGMRHGYGV---RQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHEAAAAAADNPAGTRG 192

  Fly   940 --TGEFDDTCELIGNKMFGQLSGTWDTVRIQAGELVLNRRFPKYPSSLGRQVVDHNRKWRSLFNN 1002
              ...|....|| |.|..|         ..:.|.|:.:.:..|   |..:..:...|      ::
  Rat   193 GFVLNFHADTEL-GKKKSG---------LFRRGSLLGSMKLRK---SESKSSISSKR------SS 238

  Fly  1003 FESDLANCTASTSSSGGNQSAGTLRKSSKPT-----LSTAQIWNCIAVYMSK------------Q 1050
            ..||.|....|:|.:....|.|.:.....|.     .:|.:      .||.:            :
  Rat   239 VRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTE------TYMGEWKNDKRNGFGISE 297

  Fly  1051 RAR----------------------EGTK-PGNYFNNILLS------LPLPQ------------- 1073
            |:.                      :|:| .|.|.||||:.      :|:..
  Rat   298 RSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNILVRGIRKQLIPIRNTKTREKVDRAIEG 362

  Fly  1074 --------KTSSPLAKARTT-----------TSALSKLQTEAASAL------DFLGFPP----RR 1109
                    :|...:|.:||.           .:..::.:.:.|.|:      ||....|    :|
  Rat   363 AQRAAAMARTKVEIANSRTAHARAKADAADQAAVAARQECDIARAVARELSPDFYQPGPDYIKQR 427

  Fly  1110 IQS--------QEALNSKPGGLQRADSLISMGHNTSRDLDNSSLASFQLDQSLMNSTVNGDESST 1166
            .|.        :|.:..||...:.:......|....|..:.|...|.....|...|....:.||.
  Rat   428 FQEGVDIKENPEEKVPEKPPSPKESPHFYRKGTTPPRSPEASPKQSHSPQPSSPKSMKKQNPSSG 492

  Fly  1167 FNESFSKLSHNNNNSISKHMNNIDCSITSTTSTTSAVLDQVPSFGMALVLTEQDVTSIRLYLEQA 1231
                 ::|||:..|:..:.:..|         ....::.:.||..:...:::
  Rat   493 -----ARLSHDKRNTAEEQVVAI---------VNKPLMSKAPSKELGATVSK------------- 530

  Fly  1232 FKDRHHPLYVLNERIANCFHYSYGYWKVKPTP 1263
            :..||   ||.|..........:||:....||
  Rat   531 YSGRH---YVPNPSNGELHSQYHGYYVKLNTP 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
Jph1	NP_001100100.1	PLN03185	4..>143	CDD:215619	39/141 (28%)
		PLN03185	106..>325	CDD:215619	40/246 (16%)
		PspC_subgroup_2	<410..621	CDD:411408	32/180 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810