DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and Rcbtb2

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	XP_038949091.1	Gene:	Rcbtb2 / 290363	RGDID:	735048	Length:	585	Species:	Rattus norvegicus

Alignment Length:	335	Identity:	71/335 - (21%)
Similarity:	128/335 - (38%)	Gaps:	92/335 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 DLQLLRTDVV------DMDFCSGSQELFVVLTNGSVQRQATGSGRDVGHPHAWQTLGFDPLELHA 134
            :|||:|...|      ::.:.:.:.|:||:.||.|                  ..||...::...
  Rat    75 ELQLIRQACVFGTAGNEVLYTTVNDEIFVLGTNCS------------------GCLGVGDIQSTI 121

  Fly   135 EGVRI-----RRVCCSAQG----VVFVGASGETYVMGSCGEVFKAEQQ-----------PRHMRL 179
            |..|:     :::...:.|    :|.....||.:..|     ..|..|           |.|:..
  Rat   122 EPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWG-----HNAYSQLGNGTTNHGLVPCHIST 181

  Fly   180 YEEGKELLDLAAGNEHFVMLVAP-------YNLADDALQLSVASAKEEPEDERAS-------VKS 230
            ....|:::::|.|:.|.::|.:.       ||   ::.|:...|...:|...|.:       |.|
  Rat   182 NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYN---NSGQVGSGSTANQPIPRRVTGCLQNKVVMS 243

  Fly   231 ISSGHSERSVAANTRHLLHQGYALLHTQLFTFGASNNGLLGSGDHIRRANVMRLQKLDSMGVCSI 295
            |:.|........:|            .:::.:|.:.||.||.|....:....|:..|..:.|..:
  Rat   244 IACGQMCSMAVVDT------------GEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRV 296

  Fly   296 AAGLEHTVARTLDGRLYHWGLNNHSQLG----EDVSSPMEITITENTAALPIEQNSALE-ATCGD 355
            |.|..||:..|.:|::|.||.|::.|||    .:.|.|..:.         :|::..:| |.|..
  Rat   297 ACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVV---------VEKDRIIEIAACHS 352

  Fly   356 YHTLLLNASG 365
            .||....:.|
  Rat   353 AHTSAAKSQG 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	13/45 (29%)
		RCC1_2	292..321	CDD:290274	11/28 (39%)
		RCC1	308..361	CDD:278826	16/57 (28%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
Rcbtb2	XP_038949091.1	ATS1	<141..421	CDD:227511	55/251 (22%)
		BTB_POZ_RCBTB2_CHC1L	408..524	CDD:349663
		BACK_RCBTB2	521..585	CDD:350604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900