DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and Rsph10b

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	XP_006248920.1	Gene:	Rsph10b / 288478	RGDID:	1311893	Length:	906	Species:	Rattus norvegicus

Alignment Length:	371	Identity:	82/371 - (22%)
Similarity:	144/371 - (38%)	Gaps:	93/371 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   606 SSNDRNPRIV-QFRGRHRRVILTSALVPLKLVTSGISRSSNSFILFSDFLCQVSGNSLYSYP-LT 668
            ||...||... |.....::.:..||::|  ::.:.:.::...   .|:...|....:.|..| ||
  Rat    20 SSISDNPEAAKQEISASKQEVAPSAVIP--VLETPLKQTPKR---DSEHTYQSEDETQYEEPILT 79

  Fly   669 TLWVWT-EGDSLRLTTPEKSFLV--STRSQEMRKVWLD---QLQSSIIASLGKPLGSPVPSYRST 727
            .|.|.: ||:.:|.....:.|.|  ...:...|.:|:.   ::.::::..|..|..       ||
  Rat    80 KLIVESYEGEKVRGLYEGEGFAVFQGGNTYHDRSLWMRGRLRVGTTLLLLLLLPSA-------ST 137

  Fly   728 GYEFSREHPKFSRVKACGTWRKGVLHG-NCYL----------------------EYPDGSVYCGE 769
            ..:              |.:.:|::|| ..|:                      .:||||.|.||
  Rat   138 SLQ--------------GMFSEGLMHGQGTYIWADGLKYEGDFVKNIPMNHGVYTWPDGSTYEGE 188

  Fly   770 LQHGIIEGFGKMVIPTTGL-YVGNFKGGRFHGHG----------------VYE------MHCKDS 811
            :.:|:..|||.....|..: |:|::..|:.||.|                ||.      :.|..|
  Rat   189 VVNGMRNGFGMFKCGTQPVSYIGHWCHGKRHGKGSIYYNQEGTSWYEGDWVYNIKKGWGIRCYKS 253

  Fly   812 PESEVYEGNFCEGLFHGHGVMR--NNRYIYVGEYQANARSGYGV----IEDLVSG-----DKYMG 865
              ..:|||.:...:.||.|.||  .....|.|.::...::|:|.    ::.:.:.     ::|:|
  Rat   254 --GNIYEGQWENNMRHGEGRMRWLTTNEEYTGHWEKGIQNGFGTHTWFLKRIPNSQYPLRNEYIG 316

  Fly   866 MFADNKRSGIGSCITNRGDYFEGSFSGDDLTGSGVAVFENDYYYEG 911
            .|.:..|.|.|......|..:||.:..:...|.|...|:|...|||
  Rat   317 AFVNGFRHGQGKFYYASGAMYEGEWVSNKKQGRGRITFKNGRVYEG 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622	20/105 (19%)
		VPS9	1373..1479	CDD:280383
Rsph10b	XP_006248920.1	PLN03185	86..>200	CDD:215619	27/134 (20%)
Rsph10b	XP_006248920.1	PLN03185	158..>421	CDD:215619	50/207 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900