Protein Alignment Als2 and Zzef1

DIOPT Version :10

• Sequence 1: NP_649347.1
• Gene: Als2 / 40410
• FlyBaseID: FBgn0037116
• Length: 1486
• Species: Drosophila melanogaster
• Sequence 2: NP_001414229.1
• Gene: Zzef1 / 287476
• RGDID: 1311189
• Length: 2965
• Species: Rattus norvegicus
• Alignment Length: 1683
• Identity: 305/1683 - (18%)
• Similarity: 516/1683 - (30%)
• Gaps: 665/1683 - (39%)

  Fly    72 REHMDLQLLRTDVVDMDFCSGSQELFVVLTNGSVQ--------RQATGSGRDVGHPHAWQTLGFD 128
            |...|||    :|.|:...|.......:|.|.::.        ::....|.|. ..|..:.:||.
  Rat   323 RSASDLQ----EVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT-RIHGLRAVGFQ 382

  Fly   129 PLELHAEGVRIRRVCCSAQGVVF-------VGASGET---YVMGSCGEVFKAEQQPRHMRLYEEG 183
              .:...||.:    ..|..:.:       |.||.||   :|........||.|   ||
  Rat   383 --RVKKSGVSV----SDASAIWYWSLLTSLVTASMETNPAFVQTVLHNTQKALQ---HM------ 432

  Fly   184 KELLDLAAGNEHFVMLVAPYNLAD-DALQLSVASAKEEPEDE---------RASVKSISSGHSER 238
             ..|.|:.|:..|...::|..|.: |:..:.:.|....||.|         |.|:..:.|
  Rat   433 -PPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAFALARGSIAKVMS----- 491

  Fly   239 SVAANTRHLLHQGYALLHTQLFTFGASNNGLLGSGDHIRRANVMR--------LQKLDSMGVCSI 295
            |:.|.:.|        |.||   :.||:  |:.|...:|::.:::        ||..|..|. ..
  Rat   492 SLCAISDH--------LDTQ---YDASS--LISSMASVRQSLLLKYGKPLQLTLQACDVKGK-ED 542

  Fly   296 AAGLEHTVAR--TLDGRLYHWGLNNHSQLGEDVSSPMEITITENTAALPIEQ------NSALEAT 352
            .:|.|:.:..  |.||.|        ::.|:..:|.:....||  :|..:.|      ...:.|.
  Rat   543 KSGPENLLVEPWTRDGFL--------TETGKTRASTIFSAGTE--SAFQVTQIRIMVRRGGIGAQ 597

  Fly   353 CG---DYHTLLLNASGQIHSLQPAPPMRHLQQSSTYAQTLLQ----------------------- 391
            ||   .|:    :.|.:.|:.:      |.::...|.:..||
  Rat   598 CGLVFAYN----SPSDKFHAEE------HFKRFEKYDRWKLQELRQFVKSRIGCSPDDLGEDDPI 652

  Fly   392 --LQLGAAWP------RQLRL-------LMCS---------------GGYTLQNQRQFQRQYHYY 426
              .:|...|.      :|.|:       .:|:               .||....:.:.::...|
  Rat   653 GWFELEEEWDEADVKLQQCRVAKFLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQSILY- 716

  Fly   427 LSHLQSQLQ------LLLKHRQAVQTLE---IWQRQSALEPLSALG----PLLINW--------- 469
             :|.:...:      |||:..|.:|.|.   :.|::|.|:..|.|.    .|.|.|
  Rat   717 -AHCRRDTENIYGATLLLRTLQFIQQLAHDLVQQKESGLKYKSFLDFAGLDLQIFWNFYSKLKQN 780

  Fly   470 --ERILC---LLVATLHS----LEG------------FYRADFVQPADLLFICHYKEYIDLFDGY 513
              |..:|   ||:..|.|    |:|            ..|.:.:|.|..|: .|..:.:|..||.
  Rat   781 PREECICAQTLLLQLLQSCFSVLQGDPQAVSEEEKPAAQRPEGIQAAKELY-THLCDVVDRADGE 844

  Fly   514 T----------------------------------------------------KAYCDVFSVNGF 526
            :                                                    ::.|..||....
  Rat   845 SMPMEILKQEVRNTLLNGAAIFFPDRQTRRNQLFTMMKNVTEHERKQSLQLTFRSLCTYFSDKDP 909

  Fly   527 G-------EAVVAITGLSSPLAELNEESYVTRLFQQPFSIYQLFVQFMELLV--RTQSEYGE--H 580
            |       ::.:|....|..||.:|             ::..:..:..|||:  |...|.|.  .
  Rat   910 GGLLLLPEKSDLATMNTSEVLAVMN-------------TLLSVAARECELLMLGRAHGEVGSVLF 961

  Fly   581 RVAWS-----------EFARHSCISQELAVNTKDFWSSNDRNPRIVQFRGRHRRVILTSALVPLK 634
            .:.||           :.......::|||::..:.:        :.||.. ..||||.|.|
  Rat   962 SLFWSVQGSLLSWCFLQLKSTDAAAKELAMDLIEKY--------VGQFLA-SMRVILESLL---- 1013

  Fly   635 LVTSGISRSSNSFILFSDFLCQVSGNSLYSYPLTTLWVWTEGDSLRLTTPEKSFLVSTRSQEMRK 699
                  |:.|...|:  :.||    ||::|.....|.:               ||:...:.::..
  Rat  1014 ------SQYSGKTIV--EKLC----NSVFSMAARQLVI---------------FLLDFCTLDVSH 1051

  Fly   700 VWLDQLQSSIIASLGKPLGSPVPSYRSTGYE-FSREHPKFSRVKACGTWRKGVLH---GNC---- 756
            ..|.:..|::...|.|....|.........| :.:|.|     ....||.|...|   .||
  Rat  1052 CTLLREFSTLTELLKKLCSDPEGGLSKLDVETWQQEQP-----VVLHTWTKESTHNYENNCHEVS 1111

  Fly   757 -------------------------YLEYPDGSVYCGELQHGIIEGFGKMVIPTTGLYVGNFKGG 796
                                     |||:.|.            .| ||....|.   ||.:|..
  Rat  1112 VFVSPGATYFEVEFDERCETEKRYDYLEFTDS------------RG-GKTRYDTK---VGTYKWP 1160

  Fly   797 RFHGHGVYEMHCKDSPESEVYEGNFCEGLFHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSG- 860
            :       ::..||.|..:.        |||...  .||.:.|  ::...|   ||:.:..||.
  Rat  1161 K-------KVTFKDGPRLQF--------LFHSDS--SNNEWGY--KFTVTA---YGLPDVAVSWG 1203

  Fly   861 -------DKYMGMFADNKRSGIGSCITNRGDYFEGS---FSGDDLTG-----SGVAVFENDYYYE 910
                   .:.||..|       ..|:..:..:..||   .|...||.     ....||.:....|
  Rat  1204 LDLQLLVSRLMGRLA-------SQCMALKSVHQLGSNLAISQAKLTAVLNSPLWKPVFRHQICPE 1261

  Fly   911 GELTLLGP-----NGRG---------EYYM-------PSGDACGGSGAMGTGEFDDTCE------ 948
            .||....|     :|:.         .:::       |:.:.||....:..| |...|.
  Rat  1262 LELEASWPTHPHQDGKEVKNIPDDPCRHFLLDFAQSEPAQNFCGPYSELFKG-FIQACRKQAPKT 1325

  Fly   949 --LIGNKMFGQLSGTWDTVRIQAGELVLNRRFPKYPSSLGR-----------QVVDHNRKWRSLF 1000
              :.|:.:...::.|:..:..:..:|.  .:..||..|.|:           .:.|..|.|
  Rat  1326 DIVAGSTIDQAVNATFAALVYRTPDLY--EKLQKYVHSGGKIALPEEFSQVYSLADGIRIW---- 1384

  Fly  1001 NNFESDLANCTASTSSSGGNQSAGTLRKSSKPTLSTAQIWNCIAVYMSKQRAREGTKPGNYFNNI 1065
                  :......:..|.||.|      ..|..|.||::       ..:..|:|..:     .::
  Rat  1385 ------MLEMKQKSLVSMGNDS------EEKRGLETAEV-------NPENLAKECIQ-----KSL 1425

  Fly  1066 LLSLPLPQKTSS-----------------PLAKARTTTSAL------SKLQTEAASALDFLGFPP 1107
            ||...||...||                 ||.:.:.|:|.:      |...||||:
  Rat  1426 LLLKFLPMSKSSKENCDKLVPVDETDRLQPLDRRQRTSSVVEEHFQGSASPTEAAT--------- 1481

  Fly  1108 RRIQSQEALNSKPGGLQRADSLISMGHNTSRDLDNSSLAS----------FQLDQSLMNSTVNGD 1162
                  .|.:.|..||:....|:.....::.::..:...|          |...:..:.|..:.:
  Rat  1482 ------PAADDKSPGLEMQPKLLPSSGPSAAEVSTAEEPSSPSTPTRRPPFTRGRLRLLSFRSME 1540

  Fly  1163 ES---STFNESF------------SKLSHNNNNSISKHMNNIDCSITSTTSTTSAVLDQVPSFGM 1212
            |:   .|..|.:            ..|||.              ||....|...|....:
  Rat  1541 ETRPVPTVKEKYPVLKDVMDFIKDQSLSHE--------------SIVKVLSLRKAQAQSI----- 1586

  Fly  1213 ALVLTEQDVTSIRLYLEQAFKDRH--HPLYVL--------NERIANCFHYSYG-----YWKVKPT 1262
                  .:|..|..|..::....|  ||.|:|        .:...|.|.:..|     :.:::.|
  Rat  1587 ------LEVLRIIQYCTESLGQPHCFHPPYILFLLELLTCQKDFTNYFGHLEGCGADLHKEIRDT 1645

  Fly  1263 ----PILAKQAMREWESISRRIYRFVRKMFPA----------------------------LPEEL 1295
                .:...:|::.:.||:.      |.:.||                            ||:.|
  Rat  1646 YYQLVLFLVKAIKGFSSIND------RSLLPAVSCVQTALLHLLDMGWEPSDLAFFVDIQLPDLL 1704

  Fly  1296 CQMEGSREVISHITLLYPLVLSEGIYSTLFVLYANKYSRKDEM--YRQNLNLAEKLKD 1351
            ..|  |:|.||    ::..|:|:             :|.:||:  .:||....::.:|
  Rat  1705 MNM--SQENIS----IHDSVISQ-------------WSEEDELADAKQNSEWMDECQD 1743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	ATS1	<238..>367	CDD:444065	32/147 (22%)
		PH-like	616..715	CDD:473070	22/98 (22%)
		COG4642	<745..890	CDD:443680	37/187 (20%)
		PLN03185	835..>962	CDD:215619	30/171 (18%)
		VPS9	1373..1479	CDD:460489
Zzef1	NP_001414229.1	None