DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and Sergef

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	XP_006541006.1	Gene:	Sergef / 27414	MGIID:	1351630	Length:	465	Species:	Mus musculus

Alignment Length:	412	Identity:	89/412 - (21%)
Similarity:	143/412 - (34%)	Gaps:	142/412 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 DFC--------SGSQELFVVLTNGSVQRQATGSGRD--VGHPHAWQTLGF---DPLELHAEGVRI 139
            |||        :|......|:|:|. .....|..:|  :|..|..:.|.|   .||    .|..|
Mouse    45 DFCQAGCIKSVTGGGGHSAVVTDGG-DLFVCGLNKDGQLGLGHTEEVLRFTICKPL----RGCPI 104

  Fly   140 RRVCCSAQGVVFVGASGETYVMGSCGEVFKAEQQ------------PRHMRLYEEGKELLDLAAG 192
            |:|.|.....:.:...|:..   |||.  .|..|            |:.:....|  :::.:|||
Mouse   105 RQVACGWDFTIMLTEKGQVL---SCGS--NAFGQLGVPHGPRKCVVPQAIECLRE--KVVCVAAG 162

  Fly   193 NEHFVMLVAP-------YNLADDALQLS-------VASAKEEP-----EDERASVKSISSGHSER 238
            ..|.:...|.       ..||....:|.       ..:|||..     |:..|......|.||.
Mouse   163 LRHALATTATGSVFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENSTAVCAVAGSDHSA- 226

  Fly   239 SVAANTRHLLHQGYALLHT-QLFTFGASNNGLLGSGDHIRRANVMRL-QKLDS-----MGVCSIA 296
                          :|..| :|:.:|.:.:|.|.|     ||..:.| |::::     ..|.::.
Mouse   227 --------------SLTDTGELYVWGRNKHGQLAS-----RAVFLPLPQRIEAHYFQDEKVTAVW 272

  Fly   297 AGLEHTVARTLDGRLYHWGLNNHSQLGEDVSSPMEITITENTAALPIEQNSAL------------ 349
            :|..|.||:|..|:::.||..::.|||..:..|        .|..|:||:|:|
Mouse   273 SGWTHLVAKTETGKVFTWGRADYGQLGRRLEPP--------EAQKPVEQDSSLAFQGPQNSVPSP 329

  Fly   350 --------EATCGDYHTLL---------------LNASGQIHSLQPAPPMRHLQQSSTYAQTLLQ 391
                    |.:||..|.|.               :...|...::....|::.|..|
Mouse   330 LHCLTGATEISCGSEHNLAVIRDKCCSWGWNEHGMCGDGTESNVWTPTPVQALPPS--------- 385

  Fly   392 LQLGAAWPRQLRLLMCSGGYTL 413
                   |.:|.|:.|..|::|
Mouse   386 -------PSRLLLVGCGAGHSL 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	12/51 (24%)
		RCC1_2	292..321	CDD:290274	9/28 (32%)
		RCC1	308..361	CDD:278826	18/87 (21%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
Sergef	XP_006541006.1	ATS1	22..370	CDD:227511	80/364 (22%)
Sergef	XP_006541006.1	RCC1	356..402	CDD:366085	10/61 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900