DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and Rccd1

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_775621.2	Gene:	Rccd1 / 269955	MGIID:	2444156	Length:	377	Species:	Mus musculus

Alignment Length:	336	Identity:	78/336 - (23%)
Similarity:	120/336 - (35%)	Gaps:	104/336 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 QATGSGRDVGHPHAWQTLGFDPLELHAEGVRIRRVCCSAQG---VVFVGASGETYVMGS------ 163
            ||.|||.  .|...     :.|..|||..    .:|..:.|   ...|...|...:.||
Mouse    19 QALGSGN--SHHSV-----YSPEPLHASD----DICQVSAGWSYTALVTRGGRVELSGSVSGAAD 72

  Fly   164 -CGEVFKAEQQPRHMRLYEEGKELLDL---AAGNEHFVMLVAPYN-LADDAL--QLSVASAKEEP 221
             |.:|:.:|             |||.|   ..|:...|....|.: |..:.|  |..|:.||.:.
Mouse    73 GCRDVWASE-------------ELLVLLRNKGGSSTEVQAWVPGSALQGEPLWVQNLVSGAKGQG 124

  Fly   222 EDE----------------RASV-------KSISSGHSERSVAANTRHLLHQGYALLHT--QLFT 261
            |||                ||.|       :.::.....|.:.....|:|     ||..  |:|:
Mouse   125 EDEPSRESRMGTLPLLPCARAYVTPEPPFCQPLAPELRVRQLELGAEHVL-----LLCAAGQVFS 184

  Fly   262 FGASNNGLLGSGDHIRRANVMRLQKLDSMGVCSIAAGLEHTVARTLDGRLYHWGLNNHSQLG--- 323
            :||..:|.||.|..........|:.|..:.:..:|||..|:|..:..|.:|.||.|...||.
Mouse   185 WGAGRHGQLGHGTLEAELEPRLLEALQGLRMAKVAAGGWHSVCLSETGDIYIWGWNESGQLALPT 249

  Fly   324 ----------EDVSSPMEITITENTAA--------------------LPIEQNSALEATCGDYHT 358
                      |:.:...|..:.|..|.                    ||: .:.|:.|:||..||
Mouse   250 RSGTENKAEREEATELNEDGLKEELAVADAGAPAHFIAIQPFPALLDLPL-GSDAVMASCGSRHT 313

  Fly   359 LLLNASGQIHS 369
            .::..:|::::
Mouse   314 AVVTRTGELYT 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	14/45 (31%)
		RCC1_2	292..321	CDD:290274	10/28 (36%)
		RCC1	308..361	CDD:278826	19/85 (22%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
Rccd1	NP_775621.2	Interaction with KDM8. /evidence=ECO:0000250\|UniProtKB:A6NED2	1..172		39/176 (22%)
		ATS1	<159..341	CDD:227511	40/172 (23%)
		RCC1 2	179..230		15/50 (30%)
		RCC1 3	232..289		11/56 (20%)
		RCC1 4	319..372		1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900