DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and Hectd4

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	XP_006530414.1	Gene:	Hectd4 / 269700	MGIID:	3647820	Length:	4525	Species:	Mus musculus

Alignment Length:	821	Identity:	171/821 - (20%)
Similarity:	263/821 - (32%)	Gaps:	332/821 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   850 GYGVIEDLV-SGDKYMGMFADNKRSGIGSCITNRGDYFEGSFS---GDDLTGSGVAVFENDYYYE 910
            ||   ||:: :.|...|..::||.:.:|.|:|..|.|...:.|   |....|||:         .
Mouse   380 GY---EDMLPAPDSNTGSSSENKDADLGRCLTADGHYLYTTNSAGRGVSKLGSGL---------H 432

  Fly   911 GELTLLGPNGRGEYYMPSGDACGGSGAMGTGEFDDTCELIGNKMFGQLSGTWDTVRIQAGELVLN 975
            |.|       ||..|..:.:...|..|.|.|.                              :|:
Mouse   433 GTL-------RGFVYCRNEELEPGWVAYGNGH------------------------------LLH 460

  Fly   976 R--RFPKYPSSLGRQVVDHNRKWRSLFNNFESDLANC-----TASTSSSGGNQSAGTLRKSSKPT 1033
            |  .|...|.|| .||:|.|            .|..|     .||....|...|  |:..||..|
Mouse   461 RPVSFDNKPHSL-FQVIDQN------------TLQVCQTVPMPASPLPVGSTMS--TVHLSSDGT 510

  Fly  1034 LSTAQIWNCIAVYMSKQRAREGTKPGNYF----------NNILLSLPLPQKT------------- 1075
            . ...||       |.....|.|..|:..          |.:.::.||.::|
Mouse   511 Y-FYWIW-------SPASLNEKTPKGHSVFMDIFELVVENGVFVANPLQERTILMRKEGESAKSI 567

  Fly  1076 ------------SSPLAK-ARTTTSALSKLQTEAASALDFLGFPPRRIQSQE---------ALNS 1118
                        :||.|. |..|.|.:|....|..:|....|.|.:.::...         .|..
Mouse   568 NEMLLSRLSRYRASPSATLAALTGSTISNTLKEDQAANTSCGLPLKMLRKTPMYTCGTYLVMLVP 632

  Fly  1119 KPGGLQRADSLISMGHNTSRDL--DNSSLASFQ-LDQSLMNSTVNGDESSTFNESFSKLSHNNNN 1180
            .|||         .|.:.:|.|  ..|.|:|.: |..||:.:..:|..:|.     :.|.....:
Mouse   633 PPGG---------SGSSATRSLFGGTSGLSSLKILASSLVYNISDGQFASR-----ADLIDAAGS 683

  Fly  1181 SISK------------HMNNI--DCSITSTTSTTSAVLDQ------------VPSFGMALVLTEQ 1219
            |:.:            .|||:  .||        :..:||            ....|::.::||.
Mouse   684 SLGRGALVPGLGACYDTMNNMLWTCS--------NDYIDQWCNPGNQAFHYVCQRLGVSHIITEP 740

  Fly  1220 DVTSIRLYLEQAFKDRHHPLYVLNERI----ANCFHYSYGYWKVKP----TPILAKQAMREWESI 1276
            .        |:|.....    |:|:.:    |.|.| ........|    |.:|.||...|...:
Mouse   741 K--------EEAISTNE----VINQLLHHVGAMCIH-QLNLLATNPNLPITSVLGKQHPIEARHL 792

  Fly  1277 S-------------------------RRIYRF------------VRK-------MFPALPEELC- 1296
            |                         :.:::|            :|:       :..|..:::|
Mouse   793 SSICDIMEKAMVNGDTCIVRCILVVFQVVFKFFFSPQTERNRDIIRRSGLLLWQLLMAPKDQICP 857

  Fly  1297 --QMEGSREVISHITLLYP----------LVLSEG------------IYSTLF-VLYANKY-SRK 1335
              |.|....:.|.:.:|||          |||:||            |.:.|. .|..|:: |.:
Mouse   858 EIQKEVCLAISSGLNILYPGETEINNLLKLVLTEGERNSGLSQLRDVILTNLAEQLQNNRFGSDE 922

  Fly  1336 DEMYRQNLNLAEKL-------------------KD--QELVE-----------LMGHESFL--HN 1366
            |:.||.|..|...:                   ||  |:|:.           ||..::.|  :.
Mouse   923 DDHYRLNDELLHYILKIVVRESCILITKCQTVSKDDFQKLLSTVPAASSCLRYLMAVQNHLLSNT 987

  Fly  1367 VMLDPKFVESVQTLKELQ-EKFSPQDMLT-VIQRSTQLLT---EAYEHAMAANAAQLNADNMIP- 1425
            |::.|.  |:..:...|| |....|::.| ::..:||:||   |..|.......|.:|:|  ||
Mouse   988 VLIKPD--ENEDSDSSLQGETLKVQELKTSILALATQILTGCDEVLEMLQQVTTALINSD--IPD 1048

  Fly  1426 ----------LTMLTMLRAAVPHLGAELALLDDLTGGPNFQ 1456
                      :|..|||...:|      .||..|. .||.|
Mouse  1049 REQRLKGLEQVTKATMLGHLLP------VLLTSLM-HPNLQ 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383	28/100 (28%)
Hectd4	XP_006530414.1	CCDC154	149..>233	CDD:373856
		SPRY_HECT_like	2507..2662	CDD:293970
		HECTc	4127..4520	CDD:391658
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900