DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Als2 and jph-1

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_492193.2	Gene:	jph-1 / 266843	WormBaseID:	WBGene00002179	Length:	747	Species:	Caenorhabditis elegans

Alignment Length:	799	Identity:	159/799 - (19%)
Similarity:	258/799 - (32%)	Gaps:	243/799 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   759 EYPDGSVYCGELQHGIIEGFGKMVIP-TTGLYVGNFKGGRFHGHGVYEMHCKDSPESEVYEGNFC 822
            ::.||..|.|..:.|...|.|....| ..|.|.|.:..| |...|||..     |....|:|.:.
Worm     7 DFDDGGTYVGGWEEGKAHGHGVCTGPQAKGEYAGAWHYG-FEVSGVYTW-----PSGNTYQGQWQ 65

  Fly   823 EGLFHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITNRGDYFE 887
            .|..||.|:.:..|::|.||:....:..|||.:...|..:|.|.::.....|.|:.|     |.:
Worm    66 NGKRHGLGIEQRGRWLYKGEWTQGYKGRYGVRQSANSQARYQGTWSAGFHDGYGTEI-----YVD 125

  Fly   888 -GSFSGDDLTGS----GV---------AVFENDYYYEGELTLLGPNGRGEYYMPSGDACGGSGAM 938
             ||:.|..|.|.    |:         |.|.:.......||.| .:||.|....:.:.....|..
Worm   126 SGSYQGQWLRGMRHGYGIRKSTTYEKAAKFRSKSQTHASLTSL-RSGRVEEENAAEEHRHKEGLS 189

  Fly   939 GTGEFDDTCELIGNKMFGQLSGTWDTVRIQAGELVLNRRFPKYPSSLGRQVVDHNR--------K 995
            |.|.|                    .:|..:......||      ||..:.:...|        |
Worm   190 GRGGF--------------------VLRANSSAPQRRRR------SLSERSLAVKRTLLSGLRIK 228

  Fly   996 WRSLFNNFESDLANCTASTSSSGGNQSAGT--------LRKSSKPTLSTAQIWNCIAVYMSKQRA 1052
            .:....:....:|:.|.|..|||...|..:        |::..:..:..:.|...:..:.:..|:
Worm   229 KQHSTGDIHQRVASMTGSLRSSGSTMSCTSEDSLHHHGLQQPEEEAVEESSIETYMGEWKNDMRS 293

  Fly  1053 ------------------------------REGTK-PGNYFNNILLSLPLPQKTSSPLAKARTTT 1086
                                          ::||| .|.|.||||::
Worm   294 GFGVCERSDGLKYQGEWANNAKCGYGVTTFKDGTKEEGRYKNNILIA------------------ 340

  Fly  1087 SALSKLQTEAASALDFLGFPPRRIQSQEALNSKPGGLQRADSLISM-----GHNTSRDLDNSSLA 1146
                   :.....:.|:    |..:.:|.|....|...||.|:...     ...||...:.|..|
Worm   341 -------SSRRKGVIFM----RASKFREKLEQALGAASRAASIAQQKADIAASRTSTARERSEQA 394

  Fly  1147 SFQLDQSLMNSTVNGDESSTFNESFSK------LSHNNNN-----------SISKHMNNIDCSIT 1194
            ||...|:..:|.|....:..|:.||.:      |..||..           |.|:|:
Worm   395 SFIARQANDDSEVARIHAKQFDPSFKQPGTRRLLKDNNGGESFGTDLSDAISYSRHL-------- 451

  Fly  1195 STTSTTSAVLDQVPSFGMALVLTEQDVTSIRLYLEQAFKDRHHPLYVLNERIANCFHYSYGYWKV 1259
            |.|.:.....:|..|..||     :|:|.    ..:|:  .:|.:...|....| |...|||...
Worm   452 SQTHSKQHSFEQTLSVDMA-----EDMTP----PSKAY--HNHVMPNSNTNHVN-FMPQYGYSDP 504

  Fly  1260 K---PTPILAKQAMREWESISRRIYRFVRKMFPALPEELCQMEGSREVI------------SHIT 1309
            .   .|||.::..::.          .:..:.|::|......:..:.:|            |:::
Worm   505 NSQLQTPINSQDLLQP----------HIPNIDPSIPSVSIVQDDEKPLILQPQTNISQPGPSNLS 559

  Fly  1310 LLYPLVLSEGIYSTLFVLYANKYSRKDEMYRQNLNLAEKLKDQELVELMGHESFLHNVMLDPKFV 1374
            ...|.|:|            :::|..|:.|.|.:......:.|:|                .:..
Worm   560 TQAPNVMS------------SRFSLSDDHYDQYVMAGGAQQQQKL----------------RRNR 596

  Fly  1375 ESVQTLKELQEKFSPQDMLTVIQRSTQLLTEAYE--------------HAMAANAAQLNADNMIP 1425
            .|:....::.|..:...:   .:|||  |..|.:              ||....||..:.|||..
Worm   597 PSLMRQADVNESCAASGL---NRRST--LASARDRNGDVNHPGAIGATHAAKLTAATSDGDNMGS 656

  Fly  1426 LTMLTMLRAAVPHLGAELA 1444
            |..|..|......|..|.|
Worm   657 LPNLAELETQGVRLRREEA 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383	20/86 (23%)
jph-1	NP_492193.2	MORN	58..>74	CDD:197832	5/15 (33%)
		MORN	283..303	CDD:280628	1/19 (5%)
		MORN	306..328	CDD:280628	1/21 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900