DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Als2 and SERGEF

DIOPT Version :9

Sequence 1:NP_649347.1 Gene:Als2 / 40410 FlyBaseID:FBgn0037116 Length:1486 Species:Drosophila melanogaster
Sequence 2:NP_036271.1 Gene:SERGEF / 26297 HGNCID:17499 Length:458 Species:Homo sapiens


Alignment Length:388 Identity:92/388 - (23%)
Similarity:143/388 - (36%) Gaps:111/388 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 RICSNAGGELLLLTTDHALYSAKLQANREHMDLQLLRTDVVDMDFCSGSQELF------------ 97
            |..:..||...::|....|:...|     :.|.||......|:.:.:..:.||            
Human    52 RRITGGGGHSAVVTDGGDLFVCGL-----NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWD 111

  Fly    98 --VVLT-NGSVQRQATGSGRDVGHPHAWQTLGFDP--------LELHAE-------GVRIRRVCC 144
              ::|| ||.|....:.|...:|.||.       |        :|||.|       |:| ..|..
Human   112 FTIMLTENGQVLSCGSNSFGQLGVPHG-------PRRCVVPQAIELHKEKVVCIAAGLR-HAVAA 168

  Fly   145 SAQGVVFVGASGETYVMGSCGE---------VFKAEQQPRHMRLYEEGKELLDLAAGNEHFVMLV 200
            :|.|:||...:|    :.|||.         :|...::|..:...|..|.:..| ||::|...|.
Human   169 TASGIVFQWGTG----LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVL-AGSDHSASLT 228

  Fly   201 ---APY--------NLADDALQLSVASAKEEPEDERASVKSISSGHSERSVAANTRHLLHQGYAL 254
               ..|        .||::|..|.|....|....:...|.:|.||.:         ||:.|... 
Human   229 DAGEVYVWGSNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWT---------HLVAQTET- 283

  Fly   255 LHTQLFTFGASNNGLLGSGDHIRRANVMRLQKLDSMGVCS------------------IAAGLEH 301
              .::||:|.::.|.||.  .:......:|:|.||...||                  ::.|.||
Human   284 --GKMFTWGRADYGQLGR--KLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEH 344

  Fly   302 TVARTLDGRLYHWGLNNHSQLGEDVSSPMEITITENTAALPIE---QNSALEATCGDYHTLLL 361
            .:| .:.|..|.||.|.|...|:...:.:       .|..|::   .:|.|...||..|:|.|
Human   345 NLA-IIGGVCYSWGWNEHGMCGDGTEANV-------WAPKPVQALLSSSGLLVGCGAGHSLAL 399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Als2NP_649347.1 RCC1 258..304 CDD:278826 15/63 (24%)
RCC1_2 292..321 CDD:290274 12/46 (26%)
RCC1 308..361 CDD:278826 15/55 (27%)
PH-like 616..715 CDD:302622
VPS9 1373..1479 CDD:280383
SERGEFNP_036271.1 RCC1 1 15..67 4/14 (29%)
RCC1 23..64 CDD:278826 3/11 (27%)
RCC1 2 68..119 10/55 (18%)
RCC1 68..116 CDD:278826 8/52 (15%)
RCC1_2 103..132 CDD:290274 6/28 (21%)
RCC1 119..167 CDD:278826 14/55 (25%)
RCC1 3 120..171 14/58 (24%)
RCC1 4 172..230 16/62 (26%)
RCC1_2 219..243 CDD:290274 5/23 (22%)
RCC1 5 231..283 14/60 (23%)
RCC1 231..279 CDD:278826 13/56 (23%)
RCC1 6 284..351 16/69 (23%)
RCC1 284..348 CDD:278826 16/66 (24%)
RCC1 351..399 CDD:278826 15/54 (28%)
RCC1 7 352..402 15/55 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..458
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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