DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Als2 and IBTK

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	XP_006715516.1	Gene:	IBTK / 25998	HGNCID:	17853	Length:	1394	Species:	Homo sapiens

Alignment Length:	1471	Identity:	274/1471 - (18%)
Similarity:	456/1471 - (30%)	Gaps:	456/1471 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 EEGKELLDLAAGNE--HFVML----VAPYNLADDA-LQLSVASAKEEPEDERASVKSISSGHSER 238
            :||...|||...:.  |.|..    ...|...|:. ..|...|...:...|...:.|.|..:.::
Human   117 KEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQ 181

  Fly   239 SVAANTRHLLHQGYALLHTQLFTFGASNNGLLGSGDHIRRANVMRL-QKLDSMGVCSIAAGLEHT 302
            .|...    .|..:.....|::|.|....|.||.||. :...|.|| :.|:......:||..:||
Human   182 VVLCK----FHSVFLSQKGQVYTCGHGPGGRLGHGDE-QTCLVPRLVEGLNGHNCSQVAAAKDHT 241

  Fly   303 VARTLDGRLYHWGLNNHSQLGEDVSSPMEITITENTAALPIEQNSALEATCGDYHTLLLNASGQI 367
            |..|.||.:|.:|||...||| .:..|....:.....|..::..:.:....|.:||:|..
Human   242 VVLTEDGCVYTFGLNIFHQLG-IIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT----- 300

  Fly   368 HSLQPAPPMRHLQQSSTYAQTLLQLQLGAAWPRQLRLLMCSGGYTLQNQRQFQRQYHYYLSHLQS 432
                         :.:.|...|...|||.       ||..:|...:...||...     |.|...
Human   301 -------------REAVYTMGLNGGQLGC-------LLDPNGEKCVTAPRQVSA-----LHHKDI 340

  Fly   433 QLQLL---------LKHRQAVQTLEIWQ-RQSALEPLSALGPLLINWERILCLLVATLHSLEGFY 487
            .|.|:         :..|..:..|..:| ::.|.:.|        |.:::|         :.|.:
Human   341 ALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQL--------NLKKVL---------VSGGH 388

  Fly   488 RADFVQPADLLFICHYKEYIDLFDGYTKAYCDVFSVNGFGEAVVAITGLSSPLAELNEESYVTRL 552
            ....|.|.      |.||     :|..| .| :.:::|.|. |.....::|.|.:. ..:|..::
Human   389 MEYKVDPE------HLKE-----NGGQK-IC-ILAMDGAGR-VFCWRSVNSSLKQC-RWAYPRQV 438

  Fly   553 FQQPFSIYQLFVQFMELLVRTQSEYGEHRVAWSEFARHSCISQELAVNTKDFWSSNDRNPRIVQF 617
            |     |..:.:...|:|..||...| .|..|.|..|.|...:|:..|..:  ||:|.: .:...
Human   439 F-----ISDIALNRNEILFVTQDGEG-FRGRWFEEKRKSSEKKEILSNLHN--SSSDVS-YVSDI 494

  Fly   618 RGRHRRVILTSALVPLKLVTSGISRSSNSF-ILFSDFLCQVSGNSLYSYPLTT-----------L 670
            ...:.|:.|.......:.|:.....|..:| ||.||     ...|||..|..:           |
Human   495 NSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSD-----PKTSLYEIPAVSSSSFFEEFGKLL 554

  Fly   671 WVWTEGDSLRLTT--------PEKSFLVSTRSQEMRKVWLDQLQSSIIASLGKPLGSPVPSYRST 727
            ....|.||:...|        |...::::..|...:|::|....:|
Human   555 READEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS------------------- 600

  Fly   728 GYEFSREHPKFSRVKACGTWRKGVLHGNCYLEYPDGSVY---CGELQHGIIEGFGKMVIPTTGLY 789
              ||:..:.|......|..:....:|.:.: ||....:|   |..|.||
Human   601 --EFTDIYQKDEDSAGCHLFVVEKVHPDMF-EYLLQFIYTDTCDFLTHG---------------- 646

  Fly   790 VGNFKGGRFHGHGVYEMHCKDSPESEVYEGNFCEGL----FH-------GHGVMRNNRYIYVGEY 843
               ||.         .:|...:||.  |:|.....|    ||       ...|.::|:...|.|.
Human   647 ---FKP---------RIHLNKNPEE--YQGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSER 697

  Fly   844 Q----ANARSGYGVIED--------------------LVSGDKY----MGMFA------------ 868
            |    .:.:.|..:.||                    .:.|.::    :.:.|
Human   698 QKSKPKSCKKGKNIREDDPVRMLQTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQK 762

  Fly   869 -------------DNKRSGIGSCI-TNRGDYFEGSFSGDDLTGSGVAVFEN-----------DYY 908
                         |.|......|: ..|.:||....|...:..|..|..|.           ||.
Human   763 KCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYL 827

  Fly   909 YEGELTLLGPNGRGEYYMPSGDACG---GSGAMGTGEFDDTCEL--------------------- 949
            |..|..::..:...::      .|.   .:..:......:.||:
Human   828 YTDEAVVIKESQNVDF------ICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMY 886

  Fly   950 ------------IGNKMFGQLSGTWDTVRIQAGELV-LNRRFPKYPSSLGRQVV----------- 990
                        ||..|...|......| :..|.|. |:..:.|...::.|:|:
Human   887 SAKQLKLSCLQFIGLNMAALLEARSLDV-LSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISY 950

  Fly   991 ------------------DHN---------------RKWRSLFNNFE-SDLANCTAST------- 1014
                              :|:               ||.......:. ||:....:||
Human   951 LEVEDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGK 1015

  Fly  1015 -------------SSSGGNQSAGTLRKSSKPTLSTA----QIWNCIAVYM---SKQRAREGTKPG 1059
                         .|.|.....|:.|....|..:|.    :|...:..|:   |...:||..||
Human  1016 TNSVESLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKP- 1079

  Fly  1060 NYFNNILLSLPLPQKTSSPLAKARTTTSALSKLQTEAASALDFLGFPP----RRIQSQEALNSKP 1120
             :..:.:|.:..||    |:...|..|::.:.....:.|.:.    ||    |.|...|....|.
Human  1080 -WEKSPILKISAPQ----PIPSNRIDTTSSASWVAGSFSPVS----PPVVDLRTIMEIEESRQKC 1135

  Fly  1121 GGLQRADSLISMGHNTSRDLDNSSLASFQLDQSLMNSTVNGDESSTFNESFSKLSHNNNNSISKH 1185
            |...::....::.|...  |.........|.....||.:|..|:..|..|          ...|.
Human  1136 GATPKSHLGKTVSHGVK--LSQKQRKMIALTTKENNSGMNSMETVLFTPS----------KAPKP 1188

  Fly  1186 MNNIDCSITSTTSTTSAVLDQVPSFGMALVLTEQDVTS------IRLYLEQAFKDRHHPLYVLNE 1244
            :|....|:.|.:|         .||...|:..::.|||      ::   :.:||.      :.|.
Human  1189 VNAWASSLHSVSS---------KSFRDFLLEEKKSVTSHSSGDHVK---KVSFKG------IENS 1235

  Fly  1245 RIANCFHYSYGYWKVKPTPILAKQAMREWESISR------RIYRFVRKMFPALPEELCQMEGS-R 1302
            :......:|:         :|..||..:|..:|.      ...||.....|:..:..|...|: .
Human  1236 QAPKIVRWSF---------VLVAQAGVQWLDLSSPQPLPPGFKRFSCLRHPSSWDYRCSTHGTPG 1291

  Fly  1303 EVISHITLLYPLV------LSEGIYSTLFVLYANKYSRKDEMYRQNLNL-AEKLKDQELVELMGH 1360
            ...:||:.| ||:      ||..:.:...|......|..:|..:|...| ..:.|...|:::..|
Human  1292 PEGNHISDL-PLLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEH 1355

  Fly  1361 ESFLHNVMLDPKFVESVQTLKELQEKFSPQDMLTVIQRSTQ 1401
                           ::|.|....|.|...:...:::|:.|
Human  1356 ---------------AIQDLLVFYEAFGNPEEFVIVERTPQ 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	16/46 (35%)
		RCC1_2	292..321	CDD:290274	12/28 (43%)
		RCC1	308..361	CDD:278826	14/52 (27%)
		PH-like	616..715	CDD:302622	23/118 (19%)
		VPS9	1373..1479	CDD:280383	6/29 (21%)
IBTK	XP_006715516.1	ANK	25..135	CDD:238125	6/17 (35%)
		Ank_2	25..116	CDD:289560
		ANK repeat	51..82	CDD:293786
		ANK repeat	84..116	CDD:293786
		RCC1	143..192	CDD:278826	9/52 (17%)
		RCC1	195..244	CDD:278826	17/49 (35%)
		ATS1	227..>458	CDD:227511	63/298 (21%)
		RCC1	247..299	CDD:278826	14/52 (27%)
		BTB	554..>642	CDD:279045	19/109 (17%)
		BTB	565..>639	CDD:197585	14/95 (15%)
		BTB	761..867	CDD:279045	17/111 (15%)
		BTB	769..867	CDD:197585	17/103 (17%)
		SPOP_C_like	871..931	CDD:269810	9/60 (15%)
		GVQW	1248..>1284	CDD:290611	7/35 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900