DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Als2 and ALS2CL

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001177636.1	Gene:	ALS2CL / 259173	HGNCID:	20605	Length:	953	Species:	Homo sapiens

Alignment Length:	1176	Identity:	257/1176 - (21%)
Similarity:	437/1176 - (37%)	Gaps:	367/1176 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 LSHLQS-QLQLLLKHRQAVQTLEIWQRQ--SALEPLSALGPLLINWERILCLLVATLHSLE---- 484
            |:|:.| .||.||.  .|....:.|.|:  ..|:.|......|  ||    :...:||||:
Human    20 LAHVNSLVLQPLLP--AAPDPSDPWGRECLRLLQQLHKSSQQL--WE----VTEESLHSLQERLR 76

  Fly   485 -----GFYRADFVQPADLLFICHYKEYIDLFDGYTKAYCDVFSVNGFGEAV-------------- 530
                 |......::.||.:...|. |||:       :|.....|..|.:|.
Human    77 YPDSTGLESLLLLRGADRVLQAHI-EYIE-------SYTSCMVVQAFQKAAKRRSEYWRGQRKAL 133

  Fly   531 -VAITGLSSPLAELNEESYVTRLFQQPFSIYQLFVQFMELLVRTQSEYGEHRV-------AWSEF 587
             ..::|:||   |.:..:.:.:...||.:.:  ..|::.||:......|||..       |.:.|
Human   134 RQLLSGVSS---EGSVGASLGQALHQPLAHH--VQQYVLLLLSLGDTIGEHHPTRELVVNAVTLF 193

  Fly   588 AR-HSCISQEL--AVNTKDFWSSNDRNPRIVQFRGRHRRVILTSA-------------LVPLKLV 636
            .. .|.:.|||  ||.|:..|.:         .|||.|.|:.|.|             :.||:
Human   194 GNLQSFMKQELDQAVATQALWHT---------LRGRLRDVLCTPAHRLLQDSQDVPVTVAPLR-- 247

  Fly   637 TSGISRSSNSFILFSDFLCQVSGNSLYSYPLTTLWV--WTEGDSLRLTTPEKSFLVSTRSQEMRK 699
                   :...:||.|.|..:.|::::::.|..:||  ..:|.:..|.|||:.|....:..:.:.
Human   248 -------AERVLLFDDALVLLQGHNVHTFDLKLVWVDPGQDGCTFHLLTPEEEFSFCAKDSQGQA 305

  Fly   700 VWLDQLQSSIIASL-GKP----LG-----SPVPSYRSTGYEFSREHPKFSRVKAC-----GTWRK 749
            ||..::..::..:| ||.    ||     |..|..|...|.|..|.      :.|     |.|.:
Human   306 VWQWKVTWAVHQALHGKKDFPVLGAGLEPSQPPDCRCAEYTFQAEG------RLCQATYEGEWCR 364

  Fly   750 GVLHGNCYLEYPDGSVYCGELQHGIIEGFGKMVIPTTG-----LYVGNFKGGRFHGHGVYEMHCK 809
            |..||...|::|||..:.|....|:..|||..::|...     .|..:::.|...|:|:    |:
Human   365 GRPHGKGTLKWPDGRNHVGNFCQGLEHGFGIRLLPQASEDKFDCYKCHWREGSMCGYGI----CE 425

  Fly   810 DSPESEVYEGNFCEGLFHGHGVMRN-----NRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFAD 869
            .|.: |||:|.|.|||.||.||:.:     ..:.|.|.::...|||||:.||...|::|:||:..
Human   426 YSTD-EVYKGYFQEGLRHGFGVLESGPQAPQPFRYTGHWERGQRSGYGIEEDGDRGERYIGMWQA 489

  Fly   870 NKRSGIGSCITNRGDYFEGSFSGDDLTGSGVAVFENDYYYEG----ELTLLGPNGRGEYYMPSGD 930
            .:|.|.|..:|..|..::|:|..|...|.|:.:.|:|..|||    :|||:   |:|:...|:|.
Human   490 GQRHGPGVMVTQAGVCYQGTFQADKTVGPGILLSEDDSLYEGTFTRDLTLM---GKGKVTFPNGF 551

  Fly   931 ACGGSGAMGTGEFDDTCELIGNKMFGQLSGTWDTVRIQAGELVLNRRFPKYPSS-----LGRQVV 990
            ...||...|.|....|            .|..||..:           |..|||     ||....
Human   552 TLEGSFGSGAGRGLHT------------QGVLDTAAL-----------PPDPSSTCKRQLGVGAF 593

  Fly   991 DHNRKWRSLFNNFESDL-ANCTASTSSSGGNQSAGTLRKSSKPTLSTAQIWNCIAVYMSKQRARE 1054
            ....:|:.:::.|...: |.|
Human   594 PVESRWQGVYSPFRDFVCAGC-------------------------------------------- 614

  Fly  1055 GTKPGNYFNNILLSLPLPQKTSSPLAKARTTTSALSKLQTEAASALDFLGFPPRRIQSQEALNSK 1119
                                                                ||.:|
Human   615 ----------------------------------------------------PRDLQ-------- 619

  Fly  1120 PGGLQRADSLISMGHNTSRDLDNSSLASFQLDQSLMNSTVNGDESSTFNESFSKLSHNNNNSISK 1184
                   ::|:.....:||:|..|
Human   620 -------EALLGFDVQSSRELRRS----------------------------------------- 636

  Fly  1185 HMNNIDCSITSTTSTTSAVLDQVPSFGMALVLTEQDVTSIRLYLEQAFKDRHHPLYVLNERIANC 1249
             .:.:.|..|....:..::.|.:..     :|..::..:::|||.:|..:..|||..|...:...
Human   637 -QDYLSCERTHPEDSVGSMEDILEE-----LLQHREPKALQLYLRKALSNSLHPLGKLLRTLMLT 695

  Fly  1250 FHYSY-GYWKVKPTPILAKQAMRE-----WESISRRIYRFVRKMFPALPEELCQMEGSREVISHI 1308
            |..:| |....|....||::.:::     |.:....:...:.:...||.|:  :...:|::..|
Human   696 FQATYAGVGANKHLQELAQEEVKQHAQELWAAYRGLLRVALERKGQALEED--EDTETRDLQVH- 757

  Fly  1309 TLLYPLVLSEGIYSTLFVLYANKYSRKDEMYRQNLNLAEKLKDQELVELMGHESFL--------- 1364
            .|:.||:| ...||.||.||...:.|:|..|.|.:.......|.:|:|.:..:..|
Human   758 GLVLPLML-PSFYSELFTLYLLLHEREDSFYSQGIANLSLFPDTQLLEFLDVQKHLWPLKDLTLT 821

  Fly  1365 ----HNVMLDPKFVESVQTLKELQEKFSPQDMLTVIQRS--------TQLLTEAYEHAMAANAAQ 1417
                ::::.|..|:.:.:.|:::.....|::.|.|::|:        :::|...|         :
Human   822 SNQRYSLVRDKCFLSATECLQKIMTTVDPREKLEVLERTYGEIEGTVSRVLGREY---------K 877

  Fly  1418 LNADNMIPLTMLTMLRAAVPHLGAELALLDDLTGGPNFQAEMNGMAGYCYTTLKAAYEHVTSR-- 1480
            |..|:::||.:..:.||.:.|||||:.|:.|:. .||   ...|:..:..|.|::.|||:...
Human   878 LPMDDLLPLLIYVVSRARIQHLGAEIHLIRDMM-DPN---HTGGLYDFLLTALESCYEHIQKEDM 938

  Fly  1481 ALQKIP 1486
            .|.::|
Human   939 RLHRLP 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622	26/114 (23%)
		VPS9	1373..1479	CDD:280383	29/113 (26%)
ALS2CL	NP_001177636.1	PH-like	223..321	CDD:302622	22/106 (21%)
		COG4642	358..519	CDD:226989	55/165 (33%)
		MORN 1	358..380		9/21 (43%)
		MORN	358..378	CDD:280628	7/19 (37%)
		MORN 2	381..403		6/21 (29%)
		MORN 3	409..431		6/26 (23%)
		MORN 4	432..452		10/19 (53%)
		MORN 5	459..479		9/19 (47%)
		COG4642	480..>569	CDD:226989	31/103 (30%)
		MORN 6	483..505		8/21 (38%)
		MORN 7	506..528		7/21 (33%)
		MORN 8	529..552		10/25 (40%)
		VPS9	834..938	CDD:280383	29/116 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11700
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2770
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D25604at33208
OrthoFinder	1	1.000	-	-		FOG0002992
OrthoInspector	1	1.000	-	-		otm41871
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46089
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5555
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.960