DRSC/TRiP Functional Genomics Resources

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Protein Alignment Als2 and ZZEF1

DIOPT Version :10

Sequence 1:NP_649347.1 Gene:Als2 / 40410 FlyBaseID:FBgn0037116 Length:1486 Species:Drosophila melanogaster
Sequence 2:XP_016879871.1 Gene:ZZEF1 / 23140 HGNCID:29027 Length:2966 Species:Homo sapiens


Alignment Length:635 Identity:116/635 - (18%)
Similarity:195/635 - (30%) Gaps:225/635 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   160 VMGSCGEVFKAEQQPRHMRLYEEGKELLDLAAGNEHFVMLVAP---YNLADDALQLSVASAKEEP 221
            ::|.|  :.||.|          ||.|..||      ::.|.|   .:|.|.||.::|.:...|.
Human  1943 LVGDC--LMKAHQ----------GKGLKALA------LLGVLPDGDSSLEDQALPVTVPTGASEE 1989

  Fly   222 EDERASVKSISSGHSERSVAANTRHLLHQGYALLHTQLFTFGASNNGLLGSGDHIRRANVMRLQK 286
            :.|:.:|:.     :|.|.|.|.:..:|                        :.||..:..:..|
Human  1990 QLEKKAVQG-----AELSEAGNGKRAVH------------------------EEIRPVDFKQRNK 2025

  Fly   287 LDSMGV-------CSIAAGLEHTVARTLDGRLYHWGLNNHSQLGE---DVSSPMEITITEN---T 338
            .|. ||       |                         .:|:.:   |.|.|..:...|:   :
Human  2026 ADK-GVSLSKDPSC-------------------------QTQISDSPADASPPTGLPDAEDSEVS 2064

  Fly   339 AALPIEQNSA------LEATCGDYHTLLLNASGQIHSLQPAPPMRHLQQSSTYAQTLLQLQLGAA 397
            :..|||:.:.      :.|.|.....|.|.|:       ..||::.       ..|:..:.|...
Human  2065 SQKPIEEKAVTPSPEQVFAECSQKRILGLLAA-------MLPPLKS-------GPTVPLIDLEHV 2115

  Fly   398 WPRQLRLLMCSGGYTLQNQRQFQRQYHYYLSHLQSQLQLLLKHRQAVQTLEIWQRQSALEPLSAL 462
            .|...::::.:.|:       ....||..|..|.   ||:::...|.....:.:..||...|.|.
Human  2116 LPLMFQVVISNAGH-------LNETYHLTLGLLG---QLIIRLLPAEVDAAVIKVLSAKHNLFAA 2170

  Fly   463 GPLLI---NWERILCLLVATLHSLEGFYRADFVQPADLLFICHYKEYIDLFDGYTKAYCDVFSVN 524
            |...|   .|:        |.|.|.............|.:.|...|.:.             |:|
Human  2171 GDSSIVPDGWK--------TTHLLFSLGAVCLDSRVGLDWACSMAEILR-------------SLN 2214

  Fly   525 GFGEAVVAITGLSSPLAELNEESYVTRLFQQ-PFSIYQLFVQFMELLVRTQSEYGEHRVAWSEFA 588
                        |:||......::.....:| ||.:....:..:.:||.                
Human  2215 ------------SAPLWRDVIATFTDHCIKQLPFQLKHTNIFTLLVLVG---------------- 2251

  Fly   589 RHSCISQELAVNTKDFWSSNDRNPRIV----QFRGRHRRVIL------TSALVPLKLVTSG---- 639
                ..|.|.|.|:..:..|...|..|    .|..::|.||:      ...:...:||..|    
Human  2252 ----FPQVLCVGTRCVYMDNANEPHNVIILKHFTEKNRAVIVDVKTRKRKTVKDYQLVQKGGGQE 2312

  Fly   640 -------ISRSSNSFILFSDFLCQVSGNSLYSYPLTTLWVWTEGDSLRLTTPEKSFLVSTRSQEM 697
                   :|:.|..|...:..|.|.|.:|.....:...||        |:...|....:.::...
Human  2313 CGDSRAQLSQYSQHFAFIASHLLQSSMDSHCPEAVEATWV--------LSLALKGLYKTLKAHGF 2369

  Fly   698 RKVWLDQLQSSIIASLGKPLGSPVPSYRSTGYEFSREHPKFSRVKACGTW 747
            .::....||:.::..|.|..        |.|..||:            ||
Human  2370 EEIRATFLQTDLLKLLVKKC--------SKGTGFSK------------TW 2399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Als2NP_649347.1 ATS1 <238..>367 CDD:444065 24/147 (16%)
PH-like 616..715 CDD:473070 21/115 (18%)
COG4642 <745..890 CDD:443680 2/3 (67%)
PLN03185 835..>962 CDD:215619
VPS9 1373..1479 CDD:460489
ZZEF1XP_016879871.1 FRQ1 <95..141 CDD:444056
APC10-ZZEF1 251..380 CDD:176488
CUB <1120..1190 CDD:412131
ZZ_EF 1782..1829 CDD:239083
ZZ 1831..1878 CDD:239069
Blue background indicates that the domain is not in the aligned region.

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