DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Als2 and ZZEF1

DIOPT Version :9

Sequence 1:NP_649347.1 Gene:Als2 / 40410 FlyBaseID:FBgn0037116 Length:1486 Species:Drosophila melanogaster
Sequence 2:XP_016879871.1 Gene:ZZEF1 / 23140 HGNCID:29027 Length:2966 Species:Homo sapiens


Alignment Length:635 Identity:116/635 - (18%)
Similarity:195/635 - (30%) Gaps:225/635 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   160 VMGSCGEVFKAEQQPRHMRLYEEGKELLDLAAGNEHFVMLVAP---YNLADDALQLSVASAKEEP 221
            ::|.|  :.||.|          ||.|..||      ::.|.|   .:|.|.||.::|.:...|.
Human  1943 LVGDC--LMKAHQ----------GKGLKALA------LLGVLPDGDSSLEDQALPVTVPTGASEE 1989

  Fly   222 EDERASVKSISSGHSERSVAANTRHLLHQGYALLHTQLFTFGASNNGLLGSGDHIRRANVMRLQK 286
            :.|:.:|:.     :|.|.|.|.:..:|                        :.||..:..:..|
Human  1990 QLEKKAVQG-----AELSEAGNGKRAVH------------------------EEIRPVDFKQRNK 2025

  Fly   287 LDSMGV-------CSIAAGLEHTVARTLDGRLYHWGLNNHSQLGE---DVSSPMEITITEN---T 338
            .|. ||       |                         .:|:.:   |.|.|..:...|:   :
Human  2026 ADK-GVSLSKDPSC-------------------------QTQISDSPADASPPTGLPDAEDSEVS 2064

  Fly   339 AALPIEQNSA------LEATCGDYHTLLLNASGQIHSLQPAPPMRHLQQSSTYAQTLLQLQLGAA 397
            :..|||:.:.      :.|.|.....|.|.|:       ..||::.       ..|:..:.|...
Human  2065 SQKPIEEKAVTPSPEQVFAECSQKRILGLLAA-------MLPPLKS-------GPTVPLIDLEHV 2115

  Fly   398 WPRQLRLLMCSGGYTLQNQRQFQRQYHYYLSHLQSQLQLLLKHRQAVQTLEIWQRQSALEPLSAL 462
            .|...::::.:.|:       ....||..|..|.   ||:::...|.....:.:..||...|.|.
Human  2116 LPLMFQVVISNAGH-------LNETYHLTLGLLG---QLIIRLLPAEVDAAVIKVLSAKHNLFAA 2170

  Fly   463 GPLLI---NWERILCLLVATLHSLEGFYRADFVQPADLLFICHYKEYIDLFDGYTKAYCDVFSVN 524
            |...|   .|:        |.|.|.............|.:.|...|.:.             |:|
Human  2171 GDSSIVPDGWK--------TTHLLFSLGAVCLDSRVGLDWACSMAEILR-------------SLN 2214

  Fly   525 GFGEAVVAITGLSSPLAELNEESYVTRLFQQ-PFSIYQLFVQFMELLVRTQSEYGEHRVAWSEFA 588
                        |:||......::.....:| ||.:....:..:.:||.                
Human  2215 ------------SAPLWRDVIATFTDHCIKQLPFQLKHTNIFTLLVLVG---------------- 2251

  Fly   589 RHSCISQELAVNTKDFWSSNDRNPRIV----QFRGRHRRVIL------TSALVPLKLVTSG---- 639
                ..|.|.|.|:..:..|...|..|    .|..::|.||:      ...:...:||..|    
Human  2252 ----FPQVLCVGTRCVYMDNANEPHNVIILKHFTEKNRAVIVDVKTRKRKTVKDYQLVQKGGGQE 2312

  Fly   640 -------ISRSSNSFILFSDFLCQVSGNSLYSYPLTTLWVWTEGDSLRLTTPEKSFLVSTRSQEM 697
                   :|:.|..|...:..|.|.|.:|.....:...||        |:...|....:.::...
Human  2313 CGDSRAQLSQYSQHFAFIASHLLQSSMDSHCPEAVEATWV--------LSLALKGLYKTLKAHGF 2369

  Fly   698 RKVWLDQLQSSIIASLGKPLGSPVPSYRSTGYEFSREHPKFSRVKACGTW 747
            .::....||:.::..|.|..        |.|..||:            ||
Human  2370 EEIRATFLQTDLLKLLVKKC--------SKGTGFSK------------TW 2399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Als2NP_649347.1 RCC1 258..304 CDD:278826 7/52 (13%)
RCC1_2 292..321 CDD:290274 2/35 (6%)
RCC1 308..361 CDD:278826 11/64 (17%)
PH-like 616..715 CDD:302622 21/115 (18%)
VPS9 1373..1479 CDD:280383
ZZEF1XP_016879871.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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