DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Als2 and Zzef1

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	XP_006532664.1	Gene:	Zzef1 / 195018	MGIID:	2444286	Length:	2953	Species:	Mus musculus

Alignment Length:	1264	Identity:	244/1264 - (19%)
Similarity:	402/1264 - (31%)	Gaps:	443/1264 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 SLQPAPPMRHLQQSSTYAQTL--LQLQLG----AAWPRQLRLLM------CSGGYTLQNQRQFQR 421
            :|:||||...| .|..:...|  |:.:||    :....|.|.|:      |||       .||:.
Mouse    62 ALRPAPPCESL-VSRHHGALLRWLEERLGRGEESVTLEQFRELLEARGAGCSG-------EQFEE 118

  Fly   422 QYHYY----------------------------LSHLQSQLQ----------------------- 435
            .:..:                            |||:..|||
Mouse   119 AFAQFDAEGDGTVDAENMLEALKNSSGANLQGELSHVIRQLQACSLVPGFIDIFSESKEGLGIHS 183

  Fly   436 -LLLK--HRQAVQTLEIWQRQSALEPLSALGPLLINWERILCLLVATL-HSLEGFYRADFVQPAD 496
             ::|:  ||..:.::.|        |.    |:|.:...:..:..:.| .||:...:.:...|.|
Mouse   184 SMILRFLHRNRISSMVI--------PY----PMLDHCNNMCTMRSSVLKESLDQLVQKEKESPGD 236

  Fly   497 LLFICHYKEYIDLFDGYTKAY---------CDVFSVNGFGE------------------------ 528
            |.    ....:|.....||.|         .|::.:.. ||
Mouse   237 LA----RSPEMDKLKSVTKCYAYIETSSNPADIYRMTN-GETSSYWQSDGSARSHWIRLKMKPDV 296

  Fly   529 --------------------AVVAITGLSSPLAEL-------NEESYVTRLFQQPFSIYQLFVQF 566
                                ..||:...:|.|.|:       |...|||.|  :..:|.||:||.
Mouse   297 VLRHLSIAVAATDQSYMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLL--ENANISQLYVQI 359

  Fly   567 MELLVRTQSE------YGEHRVAWSEFARHSCISQELAVNTKD-----FWS--------SNDRNP 612
            .  :.|..|:      :|...|.:...       ::..|:..|     :||        |.:.||
Mouse   360 N--IKRCLSDGCDTRIHGLRAVGFQRV-------KKSGVSVSDASAIWYWSLLTSLVTASMETNP 415

  Fly   613 RIVQFRGRHRRVILTSALVPLKLVTSGISRSSNSFILFSDFLCQVSGNSLYSYPLTTLWVWTEGD 677
            ..|| ...|........:.||.|     |..|..|..|      :|.|           |..|.|
Mouse   416 AFVQ-TVLHNTQKALQHMPPLSL-----SPGSTDFSTF------LSPN-----------VLEEVD 457

  Fly   678 S--LRLT----TPEKSFLVSTRSQEMRKVWLDQLQSSII-ASLGKPLGS--PVPSYRSTGYEFSR 733
            |  :|:|    |||              |.|..|..::. .|:.|.:.|  .:..:..|.|:.|
Mouse   458 SFLIRITSCCSTPE--------------VELTLLAFALARGSIAKVMSSLCTITDHLDTQYDAS- 507

  Fly   734 EHPKFSRVKACGTWRKGVLHGNCYLEYPDGSVYCGELQHGIIEGFGKMVIPTTGLYVGNFKGGRF 798
                 |.:.:..:.|:.:|     |:|                  ||.:..|  |...:.||
Mouse   508 -----SLISSMASVRQNLL-----LKY------------------GKPLQLT--LQACDVKG--- 539

  Fly   799 HGHGVYEMHCKDSPESEVYEGNFCEGLFHGHGVMRNNRYIYVGE---YQAN------ARSGYGVI 854
                   ...|..||:.:.|....:|.....|..|.:.....|.   :|..      .|.|.|..
Mouse   540 -------KEDKSGPENLLVEPWTRDGFLTETGKTRASTIFSTGSDSAFQVTQIRIMVRRGGIGAQ 597

  Fly   855 EDLVSGDKYMGMFADNKRSGIGSCITNR---GDYFEGSFSGDDLTGSGVAVFENDYYYEGELTLL 916
            ..||        ||.|..|       |:   .::|:.              ||.  |.:.:|..|
Mouse   598 CGLV--------FAYNSPS-------NKFHAEEHFKR--------------FEK--YDKWKLQEL 631

  Fly   917 GPNGRGEYYMPSGDACGGSGAMGTGEFDDTCELIGNKMFGQLSGTWD--TVRIQ----AGELVLN 975
                  ..::.|...|...   ..||.|.    ||   :.:|...||  .|::|    |..|::.
Mouse   632 ------RQFVKSRIGCSSD---DLGEDDP----IG---WFELEEEWDEADVKLQQCRVAKFLMVK 680

  Fly   976 RRFPKYPSS--LGRQVVDHNRKWRSLFNNFESDL--ANCTASTSSSGGNQSAGTLRKSSKPTLST 1036
            ....:..|:  ||.|.:..:...|......|..:  |:|...|.:..|    .||      .|.|
Mouse   681 FLCTRQESAERLGVQGLSISGYLRPARAEAEQSILYAHCRRDTENIHG----ATL------LLRT 735

  Fly  1037 AQIWNCIAVYMSKQRAREGTKPGNYFNNILLSLPLPQKTSSPLAKAR-----TTTSALSKLQTEA 1096
            .|....::..:.:|: ..|.|..::.:...|.|.:..|..|.|.:.|     ...:.|.||....
Mouse   736 LQFIQQLSHDLMQQK-ESGLKHKSFLDFAGLDLQIFWKFYSKLKQNRREECICAQTLLLKLLQSC 799

  Fly  1097 ASALDFLGFPPRRIQSQEALNSKPGGLQRADSLISMGHNTSRDLDNSSLASFQLDQSLMNSTVNG 1161
            .|.|.  |.|....:.::....:..|:|.|..|.:...|.....:.:|:....|.|.:.|:.:||
Mouse   800 FSVLQ--GDPQAASEEEKPTAQRSEGIQAAKELYTHLCNVVDKPNGNSMPMEILKQEVRNTLLNG 862

  Fly  1162 ------DESSTFNESFSKLSHNNNNSISKHMNNIDCSITSTTSTTSAVLDQVPSFGMALVLTEQD 1220
                  |..:..::.|:.:     .|:::|.......:| ..|..:...|:.|. |:.|:..:.|
Mouse   863 AAIFFPDRQTRRSQLFTMM-----KSVTEHERKQSLQLT-FHSLCTYFSDKDPG-GLLLLPEKSD 920

  Fly  1221 VTSIRLYLEQAFKDRHHPLYVLNERIA-----------NCFHYSYG------YWKV--------- 1259
            :.::         :....|.|:|..::           |..|.:.|      :|.|
Mouse   921 LATM---------NTSEVLAVMNTLLSVAARECELLMLNRSHGAVGSVLFSLFWSVQGSLLSWCF 976

  Fly  1260 ---KPTPILAKQ-AMREWESISRRIYRFVRKMFPALPEELCQMEGSREVISHITLLYPLVLSEGI 1320
               |.|...||: ||   :.|.:.:.:|:..|...|...|.|..|...|......::.:...:.:
Mouse   977 LQLKSTDAAAKELAM---DLIEKYVGQFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLV 1038

  Fly  1321 -----YSTLFVLYANKYSRKDEMYRQNLNLAEKLKDQELVELMGHESFLHNVMLDPKFVESVQTL 1380
                 :.||.|.:..       :.|:...|.|.||               .:..||:     ..|
Mouse  1039 IFLLDFCTLDVSHCT-------LLREFSTLTELLK---------------KLCSDPE-----GGL 1076

  Fly  1381 KELQEKFSPQDMLTVIQRSTQLLTEAYEH 1409
            .:|..:...|:...|:...|:..|..||:
Mouse  1077 SKLDVETWQQEQPVVLHTWTKESTHNYEN 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622	24/105 (23%)
		VPS9	1373..1479	CDD:280383	8/37 (22%)
Zzef1	XP_006532664.1	EFh	<94..141	CDD:238008	8/53 (15%)
		APC10-ZZEF1	250..380	CDD:176488	24/134 (18%)
		CUB	<1119..1189	CDD:381774
		ZZ_EF	1779..1826	CDD:239083
		ZZ	1828..1875	CDD:239069
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900