DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and ran-3

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_495753.1	Gene:	ran-3 / 174332	WormBaseID:	WBGene00004304	Length:	569	Species:	Caenorhabditis elegans

Alignment Length:	330	Identity:	77/330 - (23%)
Similarity:	124/330 - (37%)	Gaps:	99/330 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 GSGRDVGHP-----------HAWQTLGFDPLELHAEGVRIRRVCCSAQGVVFVGASGETYVM--- 161
            |.|..:|||           ..::..|..||:..|.||  .....:::|.|::....|...:
Worm   158 GEGEALGHPGRTTTKKPRKVDIFEEEGLKPLQAVAGGV--HSAVLTSEGEVYMCGINEKGTVPAE 220

  Fly   162 -----GSCGEVFKAEQQPRHMRLYEEGKELLDLAAGNEHFVML------VAPYNLADDALQLSV- 214
                 ||..|..|.:.:.   .:.:||| ::.||||......|      :|..||.:....:.|
Worm   221 GVEKEGSTDEFAKVKFEE---DIEKEGK-IVMLAAGASFTAALTDQGSVIAWGNLRNSNGNVDVH 281

  Fly   215 ---ASAKEEP-----EDERASVKSISSGHSERSVAANTRHLLHQGYALLHTQ--LFTFGASNNGL 269
               ...:|.|     :.:|..||          :||...||:     :|..:  |.|||....|.
Worm   282 PLLHKMQEAPVVIVHQAKRKIVK----------IAAGENHLV-----MLDEKGCLLTFGDGEMGQ 331

  Fly   270 LG----------------SGDHIRRANVMRLQK----LDSMGVCSIAAGLEHTVARTLDGRLYHW 314
            ||                ||||:  ...:|.:.    .|.:.....|:|. .|:....||:.|.:
Worm   332 LGRSSRTKTIRSKYMCDESGDHL--LVPLRFKHKGKFFDVVAKNVFASGF-WTIVHGEDGKYYAF 393

  Fly   315 GLNNHSQL---------GEDVSSPMEITITENTAALPIEQNS-ALEATC----GDYHTLLLNASG 365
            ||||::||         |:|.....|:.:     .||.|..: ..|.|.    |..|.::|.:.|
Worm   394 GLNNYAQLGIKVDEADVGQDGQDNRELRV-----FLPAEAPAFGAERTFVNIEGVQHVVILGSDG 453

  Fly   366 QIHSL 370
            ::.::
Worm   454 KVFAM 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	16/67 (24%)
		RCC1_2	292..321	CDD:290274	10/28 (36%)
		RCC1	308..361	CDD:278826	19/66 (29%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
ran-3	NP_495753.1	ATS1	163..569	CDD:227511	75/325 (23%)
		RCC1_2	189..215	CDD:290274	6/27 (22%)
		RCC1_2	246..276	CDD:290274	8/29 (28%)
		RCC1_2	302..331	CDD:290274	11/43 (26%)
		RCC1	510..565	CDD:278826
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900