DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Als2 and Ibtk

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001074751.1	Gene:	Ibtk / 108837	MGIID:	1918677	Length:	1352	Species:	Mus musculus

Alignment Length:	1378	Identity:	249/1378 - (18%)
Similarity:	423/1378 - (30%)	Gaps:	469/1378 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 QLFTFGASNNGLLGSGDHIRRANVMRL-QKLDSMGVCSIAAGLEHTVARTLDGRLYHWGLNNHSQ 321
            |::|.|....|.||.||. :...|.|| :.|.......:||..:|||..|.||.:|.:|||...|
Mouse   197 QVYTCGHGRGGRLGHGDE-QTCLVPRLVEGLSGHNCSQVAAAKDHTVVLTDDGCVYTFGLNMFHQ 260

  Fly   322 LGEDVSSPMEITITENTAALPIEQNSALEATCGDYHTLLLNASGQIHSLQPAPPMRHLQQSSTYA 386
            || .:..|....:.....|..::..:.:....|.:||:|..                  :.:.|.
Mouse   261 LG-IIPPPASCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT------------------REAVYT 306

  Fly   387 QTLLQLQLGAAWPRQLRLLMCSGGYTLQNQRQFQRQYH----YYLSHLQSQLQLLLKHRQAVQTL 447
            ..|...|||       .||..:|...:...||....:|    ..|........:.:..|..:..|
Mouse   307 LGLNGGQLG-------HLLDPNGEKCVTTPRQVSALHHKDIAVSLVAASDGATVCVTTRGDIYLL 364

  Fly   448 EIWQ-RQSALEPLSALGPLLINWERIL----CLLVATLHSLEGFYRADFVQPADLLFICHYKEYI 507
            ..:| ::.|.:.|        |.:::|    |:          .|:.|   |..|......|..:
Mouse   365 ADYQCKKMATKQL--------NLKKVLVSGGCM----------EYKVD---PEHLTENGGQKICV 408

  Fly   508 DLFDGYTKAYCDVFSVNGFGEAVVAITGLSSPLAELNEESYVTRLFQQPFSIYQLFVQFMELLVR 572
            ...||..:.:|              ...:||.|.:..      ..:.:..||..:.:...|:|..
Mouse   409 LAMDGAGRVFC--------------WRSISSSLKQCR------WAYPRQVSISDIALNRNEILFV 453

  Fly   573 TQSEYGEHRVAWSEFARHSC-----ISQELAVNTKDFWSSNDRNP-----RIVQFRGRHRRVILT 627
            ||...| .:..|.|..|.:.     |...|..::.|.....|.|.     |:.:....||.|.::
Mouse   454 TQDGEG-FKGKWFEDKRKNSEKKADILPNLHHSSSDVSCVPDTNSVYERIRLEKLPFAHRAVSVS 517

  Fly   628 SALVPLKLVTSGISRSSNSFILFSDFLCQVSGNSLYSYPLTTLWVWTE--GDSLRLTT------- 683
            :.       .||    .|..||.||     ...|||..|:.:...:.|  |..||.|.
Mouse   518 TD-------PSG----CNFAILQSD-----PKTSLYEIPVVSSSSFFEEFGKLLRETDEMDSFHD 566

  Fly   684 ----------PEKSFLVSTRSQEMRKVWLDQLQSSIIASLGKPLGSPVPSYRSTGYEFSREHPKF 738
                      |...::::.||...:|::|..             ||.:        |.:..:.|.
Mouse   567 VTFQVGNRHFPAHKYILAVRSDFFQKLFLSD-------------GSSL--------ELTDVYQKD 610

  Fly   739 SRVKACGTWRKGVLHGNCYLEYPDGSVY---CGELQHGIIEGFGKMVIPTTGLYVGNFKGGRFHG 800
            .....|..:....:|.:.: ||....:|   |..|.||...   :|::....
Mouse   611 EDAAGCHLFVVEKVHPDLF-EYLLQFMYTDTCDLLTHGFKP---RMIVKRKA------------- 658

  Fly   801 HGVYEMHCKDSPESEVYEGNFC------EGLFHGHGVMRNNRYIYVGEYQ----ANARSGYGVIE 855
                 ..|:.||:|.::..| |      :..|.   |.|:|:...:.|.|    .:::.|.||.:
Mouse   659 -----EDCEGSPDSHLHTVN-CHVDDKQKSAFE---VYRSNQAHTLSERQKSKPKSSKKGKGVGD 714

  Fly   856 D-----LVSGDKYMGM--------------------------------------------FADNK 871
            |     |.|..|..|:                                            ..|.|
Mouse   715 DDPVRMLQSVAKKFGLSNLSSRLEGVRLENEKINVIAKKTGNKLKLSQKKCSFLYDVTMKSVDGK 779

  Fly   872 RSGIGSCI-TNRGDYFEGSFSGDDLTGSGVAVFEN-----------DYYYEGELTLLGPNGRGEY 924
            ......|: ..|.:||....|...:..|..|..|.           ||.|..|..::..:...::
Mouse   780 EFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIKESQNVDF 844

  Fly   925 YMPSGDACG---------------------------GSGAM--------GTGEFDDTC-ELIGNK 953
                  .|.                           .:.||        ..|:...:| :.||..
Mouse   845 ------VCSVLVVADQLLITRLKEICEVALTENLTLKNAAMLLEFAALYNAGQLKLSCLQFIGLN 903

  Fly   954 MFGQLSG-------------------------------------TWDTVRIQAGELVLNRRF--- 978
            |...|..                                     ...:::::.||:......
Mouse   904 MAALLEARSLDVLSEDVLKDLSIFYRKMIPAMERRVITPYQDGPDISSMQVEDGEVFFKEEINME 968

  Fly   979 PKYPSSLGRQVVDH-NRKWRSLFNNFESD------LANCTASTSSSGGNQSAGTLRKSSKPTLST 1036
            |.|..::.::.... .:|.|.     .||      |::...|..|:|..:||.|....|.|.|.|
Mouse   969 PNYSETMFKKAKTRAKKKPRK-----RSDSSGGYTLSDVIQSPPSAGLLKSAKTNSVESLPELLT 1028

  Fly  1037 AQIWNCIAVYMSKQRAR-------------EG-TKPGNYFNNILLSLPLPQKTSSPLAKARTTTS 1087
            :......|...|.:..:             || .||  |.|.|  ..|..::...|..|:.||.|
Mouse  1029 SDSEGSYAGVASPRDLQSPDFTAGFHSDKVEGKAKP--YVNGI--PPPCTREDVKPWEKSPTTKS 1089

  Fly  1088 A---LSKLQTEAASALDFLG------FPP----RRIQSQEALNSKPGGLQRAD--SLISMGHNTS 1137
            |   :...:.:.|::..:|.      .||    |.|...|....|.|...:::  .:||.|...|
Mouse  1090 APQFIPSNRVDTAASSSWLAGSCSPVSPPVVDLRTIMETEENRQKYGAAPKSNLGKIISHGIKLS 1154

  Fly  1138 RDLDNSSLASFQLDQSLMNSTVNGDESSTFNESFSKLSHNNNNSISKHMNNIDCSITSTTSTTSA 1202
                       |..:.::..|...:.|.|                    |:::..:|:.:.:...
Mouse  1155 -----------QKQRKMIALTTKENNSGT--------------------NSMEAILTAPSKSPKP 1188

  Fly  1203 VLDQVPSFGMALVLTEQDVTSIRLYLEQAFKDRHHPLYVLNERIANCFHYSYGYWKVKPTPILAK 1267
            .....|               :...|.::|:|     ::|.|:              ||.|
Mouse  1189 ANAWAP---------------LHSPLSRSFRD-----FLLEEK--------------KPVP---- 1215

  Fly  1268 QAMREWESISRRIYRFVRKMFPALPEELCQMEGSREVISHITLLYPLVLSEGIY--STLF----- 1325
             .....:.:.:..::..... |||....|...|:..:.|:....:||:.|...:  |:|.
Mouse  1216 -GYGSGDHVKKVCFKGTENS-PALNVARCSTHGTPGLESNHVSDFPLLDSPNPWQSSSLAASPAV 1278

  Fly  1326 --VLYANKYSRKDEMYRQNLNLAEKLKDQELVELMGHESFLHNVMLDPKFVESVQTLKELQEKFS 1388
              |.:|              ::.|:.:.||...:...|..|..:.::.   .::|.|....|.|.
Mouse  1279 APVTFA--------------SIVEEERQQEAALIRSREKPLALIQVEE---HAIQDLLVFYEAFG 1326

  Fly  1389 PQDMLTVIQRSTQ 1401
            ..:...|::|:.|
Mouse  1327 NPEEFVVVERAPQ 1339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	16/46 (35%)
		RCC1_2	292..321	CDD:290274	12/28 (43%)
		RCC1	308..361	CDD:278826	14/52 (27%)
		PH-like	616..715	CDD:302622	24/117 (21%)
		VPS9	1373..1479	CDD:280383	7/29 (24%)
Ibtk	NP_001074751.1	Ank_2	25..116	CDD:289560
		ANK	<47..135	CDD:238125
		ANK repeat	51..82	CDD:293786
		ANK 1	51..80
		ANK repeat	84..116	CDD:293786
		ANK 2	85..114
		RCC1 1	141..194
		RCC1	143..192	CDD:278826
		RCC1 2	195..246		17/49 (35%)
		RCC1_2	232..260	CDD:290274	12/27 (44%)
		RCC1	247..299	CDD:278826	14/52 (27%)
		RCC1 3	248..301		14/71 (20%)
		BTB	562..>643	CDD:279045	15/102 (15%)
		BTB	566..>643	CDD:197585	15/98 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	692..716		5/23 (22%)
		BTB	762..868	CDD:279045	15/111 (14%)
		BTB	770..872	CDD:197585	15/107 (14%)
		SPOP_C_like	872..>919	CDD:269810	8/46 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	976..1002		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1094		16/65 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900