DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and jph1a

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001159728.1	Gene:	jph1a / 100147894	ZFINID:	ZDB-GENE-040724-233	Length:	683	Species:	Danio rerio

Alignment Length:	807	Identity:	161/807 - (19%)
Similarity:	275/807 - (34%)	Gaps:	245/807 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   759 EYPDGSVYCGELQHGIIEGFGKMVIPT-TGLYVGNFKGGRFHGHGVYEMHCKDSPESEVYEGNFC 822
            ::.||..|||..:.|...|.|....|. .|.|.|::..| |...|||..     |....|:|.:.
Zfish     7 DFDDGGTYCGGWEDGKAHGHGICTGPKGQGEYSGSWSHG-FEVVGVYTW-----PSGNTYQGYWS 65

  Fly   823 EGLFHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITNRGDYFE 887
            :|..||.||....:::|.||:....:..|||.:...:..:|.|.:::..:.|.|  :...||  .
Zfish    66 QGKRHGLGVETKGKWLYRGEWSHGFKGRYGVRQSTNTPARYDGTWSNGLQDGYG--VETYGD--S 126

  Fly   888 GSFSGDDLTG--SGVAVFENDYYYEGELTLLGPNGRGEYYMPSGDACGGSGAMGTGEFDDTCELI 950
            |::.|..:.|  .|..|.::..|  |..|::....|..  :.|..:...:||:......||  .:
Zfish   127 GTYQGQWMGGMRHGYGVRQSVPY--GMATIIRSPLRTS--LASLRSVQSNGAVLQDTVPDT--PV 185

  Fly   951 GNKMFGQLSGTWDTVRIQAGELVLNRRFPKYPSSLGRQVVDHNRK--WR--SLFNNFESDLANCT 1011
            |::                |..|||     :.|.  .:||...:|  :|  |||.:.. .|....
Zfish   186 GSR----------------GGFVLN-----FHSD--TEVVTGKKKGLFRRGSLFGSLR-QLRKSD 226

  Fly  1012 ASTSSSGGNQSAGTLRKSSKPTLSTAQIWNCIAVYMSKQRAREGTKPGNYFNNILLSLPLPQKTS 1076
            :.||.|....||.:....|:.:.|.|   |....|      .||..|.:|
Zfish   227 SKTSISSKRSSARSDATMSRISSSDA---NSTISY------GEGEVPDDY--------------- 267

  Fly  1077 SPL---AKARTTTSALSKLQ---------TEAASALDFLGFPPRRIQSQEALNSK---------P 1120
            :|:   ..|.||.|.:.:.:         :|.::.|.:.|         |.:|:|         |
Zfish   268 TPMEDHVDATTTESYMGEWKNDKRNGFGVSERSNGLKYEG---------EWMNNKRHGYGCTIFP 323

  Fly  1121 GGLQ--------------RADSLISMGHNTSRDLDNSSLASFQLDQSLMNSTVNGDESSTFNESF 1171
            .|.:              |...:....|.|...:|.:               |.|...|.
Zfish   324 DGTKEEGKYKNNVLVRGIRKQLIPLKNHKTKEKVDRA---------------VEGARRSA----- 368

  Fly  1172 SKLSHNNNNSISKHMNNIDCSITSTTSTTSAVLDQV-------------------PSF---GMAL 1214
                     :|::....|..|.||...|.|...||.                   |||   |:..
Zfish   369 ---------AIARTKVEIAVSRTSHARTKSEAADQAALAACQESDLARAVACELSPSFHQPGLEY 424

  Fly  1215 VLTE--QDVTSIRLYLEQAFKDRH-----HPLYVLNERIANCFHYSYGYWKVKPTPILAKQAMRE 1272
            :..:  :.|..|:   |:|.|:..     .|.|    |......:|.........|..::::..:
Zfish   425 IKQKFSEPVEEIK---EEAPKEEEKKSSGSPFY----RRGTTPSHSPAQSPTPSPPRTSQKSQAQ 482

  Fly  1273 WESISRRI-------YRFVRKMFPALPEELCQMEGSREVISHIT--------------------- 1309
            ..||||:|       .|.:.:...::..::.:.|.: .:::.||
Zfish   483 NPSISRKISKDNSVTARKISRDSTSVARKISKEERA-SIVAEITKVSVPPPPLPPPPPPAVQTIK 546

  Fly  1310 -----------LLYPLVLSEGI-YSTLFVLYANKYSRKDEMYRQNLNLAEKLKDQELVELMGHES 1362
                       .|.|:....|. ...|...|.:.|.:.    .:.|...|:.:|:| .|:.  :|
Zfish   547 LQDVPPPKPPKALEPVAKPAGTGNGQLHTAYHSYYVKP----VKQLPPPEEPEDEE-PEIT--QS 604

  Fly  1363 FLHNVMLDPKFVESVQTLKEL----QEKFSPQDMLTVIQRSTQLLTEAYEHAMAANAAQLNADNM 1423
            .|..:...||.:.:.....|:    ||...|:.:....:.|..|:.||        ..:.:..|.
Zfish   605 SLARMPPPPKTLNTPTPKPEVKIRKQESIKPKSLAETKKASLDLVEEA--------TVEESGPNS 661

  Fly  1424 IPLTMLTMLRAAVPHLGAELALLDDLT 1450
            |.:.|:.:|     ::|..:..:..||
Zfish   662 ILVAMVMLL-----NIGLAIIFVHFLT 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383	15/82 (18%)
jph1a	NP_001159728.1	MORN	106..128	CDD:280628	6/25 (24%)
jph1a	NP_001159728.1	MORN	305..327	CDD:280628	6/30 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910