DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and Rcc1

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001184011.1	Gene:	Rcc1 / 100088	MGIID:	1913989	Length:	434	Species:	Mus musculus

Alignment Length:	161	Identity:	42/161 - (26%)
Similarity:	68/161 - (42%)	Gaps:	20/161 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 VASAKEEPEDERASVKSISSGHSERSVAANTRHLLHQGYALLHTQLFTFGASNNGLLGSGDHI-- 276
            :|..:..|||.....|.:....: |..|..:..:.|:.:......:.|.|..:.|.||.|:.:
Mouse     6 IAKRRSPPEDAIPKSKKVKDTRN-RGPATRSCQVSHRSHNTEPGLVLTLGQGDVGQLGLGESVLE 69

  Fly   277 --RRANVMRLQKLDSMGVCSIAAGLEHTVARTLDGRLYHWGLNNHSQLGEDVSSPMEITITENTA 339
              :.|.|..||     .|....||..|||..:..|::|.:|.|:...||.|.|       .|.:.
Mouse    70 RKKPALVPLLQ-----DVVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTS-------VEGSE 122

  Fly   340 ALP--IE-QNSALEATCGDYHTLLLNASGQI 367
            .:|  :| |...::.:.||.||..|...|::
Mouse   123 MVPGKVELQEKVVQVSAGDSHTAALTEDGRV 153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	15/49 (31%)
		RCC1_2	292..321	CDD:290274	10/28 (36%)
		RCC1	308..361	CDD:278826	16/55 (29%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
Rcc1	NP_001184011.1	RCC1	48..95	CDD:278826	16/51 (31%)
		RCC1	98..147	CDD:278826	16/55 (29%)
		RCC1	150..200	CDD:278826	1/4 (25%)
		RCC1_2	187..216	CDD:290274
		RCC1	203..268	CDD:278826
		RCC1	271..322	CDD:278826
		RCC1	325..368	CDD:278826
		RCC1	376..427	CDD:278826
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900