DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRP5 and arr

DIOPT Version :9

Sequence 1:	XP_011543331.1	Gene:	LRP5 / 4041	HGNCID:	6697	Length:	1662	Species:	Homo sapiens
Sequence 2:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster

Alignment Length:	1740	Identity:	720/1740 - (41%)
Similarity:	1007/1740 - (57%)	Gaps:	183/1740 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    11 AVSCRKGGVRAGQ----------CLSSRNGKEEAAQYFP------ASP----------LLLFANR 49
            |..|.|.....|.          |....|..:....:.|      |||          .|||..|
  Fly    30 ATKCTKSNSGVGWRQMLIGFLLICFGISNSWQYKNVHMPSSSSLIASPPASAFVNTPATLLFTTR 94

Human    50 RDVRLVD----AGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTG----- 105
            .|:::.:    .||.:::  ::|..|.:|.|:||.::|..|.|||...|.|:....|.:.
  Fly    95 HDIQVANITRPTGGPQID--VIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSALQPLL 157

Human   106 -AAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDP 169
             |..|.|:.:||..|:|||.||...|:||||.|.||||||.|:|..:|||||.|||||||:|:.|
  Fly   158 RAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAVAVVP 222

Human   170 AHGYMYWTDWGETPRIERAGMDGS--TRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRAN 232
            |...:.||||||.|:||||.|||.  :|..:|...::|||||.:||:.:.:||.|.|..||....
  Fly   223 ARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFIDVMR 287

Human   233 LDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLS 297
            ||||.|:.:| .:|.:||:||...|.|||||||..|::|.:.:| .:.||::....:|..::...
  Fly   288 LDGSSRRTIV-NNLKYPFSLTFYDDRLYWTDWQRGSLNALDLQT-RELKELIDTPKAPNSVRAWD 350

Human   298 QERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLR 362
            ...||:....|..:||.|||||||:.:...::|||||||:| .:..||..|::|::.:.:||.:.
  Fly   351 PSLQPYEDNPCAHNNGNCSHLCLLATNSQGFSCACPTGVKL-ISANTCANGSQEMMFIVQRTQIS 414

Human   363 RISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDP 427
            :||||:||:|...|.:..:::||||||||:|.::||:|.|...|:||:.||:|....|.:|:..|
  Fly   415 KISLDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSEVRHP 479

Human   428 DGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGE-NP 491
            ||:|:||:|||||||||.||||||.||:||:||:|:.|.|:||||||:.|.:|.|:|:||.| .|
  Fly   480 DGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKP 544

Human   492 KIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPH 556
            |:|.|:|||.||.|||:.:||||||:|||::...:||.|.|||||||.|:||:.||.::.|.|.|
  Fly   545 KVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKH 609

Human   557 IFGFTLLGDFIYWTDWQRRSIERVHKVKA-SRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGG 620
            :||.::|.|::||||||||||:|.||:.. :|.|::||.|||||||...:.:|.|.|.||.||||
  Fly   610 LFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRNGG 674

Human   621 CSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISL---ETNNNDVAIPLTG 682
            |||||...|....|.|.|..||.:|.:||:||.|||:|:.:..|.|||:   |.|:||..||...
  Fly   675 CSHLCLNRPRDYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFKD 739

Human   683 VKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTG 747
            |::|.|||..|:...|||||...|.|.|||:|||.|:.:|:.||..|:|:||||:..|:||:|..
  Fly   740 VRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAE 804

Human   748 TNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKV 812
            ..|||||||||..|:||:|:.::.||||.|:|.:||:|||| .....|.||.|||::..|:|...
  Fly   805 ARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTIVAGA 868

Human   813 GRANDLTIDYADQRLYW-TDLDTNMIESSNMLGQER-VVIADDLPHPFGLTQYSDYIYWTDWNLH 875
            ..|..||.|...:|||| |......|||::..|::| :::..|:..|:.::.|.||:||:|||..
  Fly   869 NHAAGLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTG 933

Human   876 SIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPG--GHRCGCA 938
            .|||..||:|:||:|:...:.::..:|||:..||.|:|.|..|||.|..||||.||  |..|.|.
  Fly   934 DIERVHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACP 998

Human   939 SHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWV 1003
            :||.|.....:|.||..:::|||::...|::|:....|::.||:.| :|::|:||||:...|||:
  Fly   999 THYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPVSG-KNIRAVDYDPITHHIYWI 1062

Human  1004 DGR-QNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAM 1067
            :|| .:|||:..:||:..:|.:       ..||.||:|||..|.|||||..:|:|||....||::
  Fly  1063 EGRSHSIKRSLANGTKVSLLAN-------SGQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESV 1120

Human  1068 GVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTL 1132
            ||:..||.:|||.|.|:|.:..|::|::....| |.||.:||.|| |.....|....||.:|...
  Fly  1121 GVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQA-IIRARVDGNER-VELAYKLEGVTALALDQQS 1183

Human  1133 GKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKR 1197
            ..:::  |..|||::.|::|.|:.||...:|.|.:.:..||..:||:| .:..:||: ...|::|
  Fly  1184 DMIYY--AHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLD-DKTGVERI-TVNGERR 1244

Human  1198 TRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPR----CSCPVHLVLLQN 1258
            :....|:..:|.|.||.....:....|.|......|||||||.|:|..|    ||||.||:||::
  Fly  1245 SAELQRLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKHLMLLED 1309

Human  1259 LLTCGEPPTCSPDQFACAT-----GEI--DCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCAR 1316
            ...||..|.|.||.|.||.     .::  ||||.:|||||..:|.|:|||.|||.|.|.||.|..
  Fly  1310 KENCGAFPACGPDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGCPTCRADQFSCQS 1374

Human  1317 GQCVDLRLRCDGEADCQDRSDEADCDAIC-LPNQFRCASGQ-CVLIKQQCDSFPDCIDGSDE--- 1376
            |:|:|..|.|||..:|.:..|||||   | .|.:|:|...: |:.....||.:.:|.||:||
  Fly  1375 GECIDKSLVCDGTTNCANGHDEADC---CKRPGEFQCPINKLCISAALLCDGWENCADGADESSD 1436

Human  1377 LMCEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPH 1441
            :..:....|:.|..|....||..:..|.|:     ||.:   ..|:...|.:...|.:..:..|.
  Fly  1437 ICLQRRMAPATDKRAFMILIGATMITIFSI-----VYLL---QFCRTRIGKSRTEPKDDQATDPL 1493

Human  1442 VPLNFIAPGGSQHGPFTGIACGKSMMSSV--SLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYP 1504
            .|...     |:....:.||   |:..:|  |.:..|..:..|||||:||||||:::.:....||
  Fly  1494 SPSTL-----SKSQRVSKIA---SVADAVRMSTLNSRNSMNSYDRNHITGASSSTTNGSSMVAYP 1550

Human  1505 PGLGSGCMLSRMALETHISPTPFGKLHVGLGCRQWHLWKILNPPPSPATDPSLYNMDMFYSSNIP 1569
                                                    :||||||||
  Fly  1551 ----------------------------------------INPPPSPAT---------------- 1559

Human  1570 ATARPYRPYIIRGMAPPTTPCSTDVC---DSDYSA------SRWKASKY-------YLDLNSDSD 1618
            .:.||||.|.|....||.||||||:|   ||:|::      |...|:|:       .|....||:
  Fly  1560 RSRRPYRHYKIINQPPPPTPCSTDICDESDSNYTSKSNSNNSNGGATKHSSSSAAACLQYGYDSE 1624

Human  1619 PYPPPPTPHSQYLS-----AEDSCPPSPATERS-YFHLFPPPPSPCTDSS 1662
            ||||||||.|.|.|     .|.||||||::..| ||...||||||....|
  Fly  1625 PYPPPPTPRSHYHSDVRIVPESSCPPSPSSRSSTYFSPLPPPPSPVQSPS 1674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP5	XP_011543331.1	NHL	<46..>178	CDD:302697	60/141 (43%)
		NHL repeat	74..113	CDD:271320	15/44 (34%)
		LY	111..151	CDD:214531	23/39 (59%)
		NHL repeat	116..157	CDD:271320	25/40 (63%)
		Ldl_recept_b	172..212	CDD:278487	21/41 (51%)
		LY	196..238	CDD:214531	18/41 (44%)
		FXa_inhibition	308..345	CDD:291342	18/36 (50%)
		LY	375..415	CDD:214531	19/39 (49%)
		LY	417..459	CDD:214531	27/41 (66%)
		LY	460..503	CDD:214531	24/43 (56%)
		LY	504..546	CDD:214531	25/41 (61%)
		LY	547..580	CDD:214531	18/32 (56%)
		FXa_inhibition	614..649	CDD:291342	18/34 (53%)
		NHL	694..887	CDD:302697	90/194 (46%)
		LY	719..761	CDD:214531	22/41 (54%)
		NHL repeat	729..765	CDD:271320	21/35 (60%)
		NHL repeat	772..811	CDD:271320	20/38 (53%)
		NHL repeat	856..880	CDD:271320	11/23 (48%)
		FXa_inhibition	915..950	CDD:291342	17/36 (47%)
		LY	979..1018	CDD:214531	18/39 (46%)
		LY	1069..1112	CDD:214531	17/42 (40%)
		LY	1113..1155	CDD:214531	11/41 (27%)
		FXa_inhibition	1226..1262	CDD:291342	19/39 (49%)
		Ldl_recept_a	1267..1304	CDD:278486	20/43 (47%)
		LDLa	1307..1341	CDD:238060	16/33 (48%)
		LDLa	1345..1379	CDD:238060	12/38 (32%)
arr	NP_524737.2	LY	162..201	CDD:214531	23/38 (61%)
		NHL	168..503	CDD:302697	165/337 (49%)
		NHL repeat	172..237	CDD:271320	41/64 (64%)
		LY	252..293	CDD:214531	18/40 (45%)
		NHL repeat	261..298	CDD:271320	18/37 (49%)
		NHL repeat	303..339	CDD:271320	17/36 (47%)
		NHL repeat	341..419	CDD:271320	29/78 (37%)
		NHL repeat	428..476	CDD:271320	21/47 (45%)
		LY	472..511	CDD:214531	27/38 (71%)
		NHL repeat	477..503	CDD:271320	19/25 (76%)
		Ldl_recept_b	534..573	CDD:278487	24/38 (63%)
		LY	558..599	CDD:214531	25/40 (63%)
		LY	600..641	CDD:214531	21/40 (53%)
		FXa_inhibition	668..703	CDD:291342	18/34 (53%)
		LY	739..773	CDD:214531	17/33 (52%)
		LY	776..818	CDD:214531	22/41 (54%)
		LY	819..860	CDD:214531	21/41 (51%)
		FXa_inhibition	973..1010	CDD:291342	17/36 (47%)
		LY	1122..1164	CDD:214531	17/42 (40%)
		FXa_inhibition	1273..1313	CDD:291342	19/39 (49%)
		LDLa	1319..1362	CDD:238060	20/42 (48%)
		LDLa	1365..1399	CDD:238060	16/33 (48%)
		LDLa	1399..1433	CDD:197566	11/36 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5536
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1329	1.000	Inparanoid score	I146
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48457
OrthoDB	1	1.010	-	-		D121310at2759
OrthoFinder	1	1.000	-	-		FOG0004181
OrthoInspector	1	1.000	-	-		otm42137
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	1	1.100	-	-	LDO	PTHR46513
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4876
SonicParanoid	1	1.000	-	-		X3498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870