DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP5 and Lrp4

DIOPT Version :10

Sequence 1:XP_011543331.1 Gene:LRP5 / 4041 HGNCID:6697 Length:1662 Species:Homo sapiens
Sequence 2:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster


Alignment Length:1303 Identity:469/1303 - (35%)
Similarity:721/1303 - (55%) Gaps:92/1303 - (7%)


- Green bases have known domain annotations that are detailed below.


Human    44 LLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAV 108
            ||.|||.|:|.|.....:..:  :|.||.:|.|:||...||.::|:|||.:.||..|:|  |..|
  Fly   613 LLVANRWDIRRVTLSNNRYSA--IVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYMN--GTRV 673

Human   109 QNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGY 173
            ::|:..||.||.|:|.||:...|:||||.|.|:||:|..|..|.|:...|||:||||.:.|....
  Fly   674 RDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEAL 738

Human   174 MYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFR 238
            .:|:|||..|:||||.|||:.||:|:...:.|||||.||....|:||||||...|..:|||||.|
  Fly   739 AFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDR 803

Human   239 QKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPF 303
            .|::...|.|||||||..||:|||||.|:::.|.:|.||.:.:.:....:.||||......|||.
  Fly   804 NKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPE 868

Human   304 FHTRCEED----NGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLR-- 362
            :..||::|    .||||||||  |::....|.||.|:.|:::|:|||:.|::::|:|||.|:|  
  Fly   869 YADRCQKDRRGLRGGCSHLCL--PNKTSRRCGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLR 931

Human   363 --RISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEIN 425
              |.:...|:..|:::.:|:::||:|:|:.....::||||.|...|.:|:|:||..|.:|::.:.
  Fly   932 HLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLV 996

Human   426 DPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGEN 490
            .|.|:|:||:...|||||..|:||||...||..|.:|:.|.|.:||.|.::|:.|.|:|:|||::
  Fly   997 SPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVNPIEGFMFWSDWGDD 1061

Human   491 PKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLP 555
            |.||.||:||.||..:.:..|.:|||||:|.::.|:|:.|..|..:|.:|.||:.|:.:| :.|.
  Fly  1062 PMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLENMNFDGSGRQVIL-NGLG 1125

Human   556 HIFGFTLLGDFIYWTDWQRRSIERVHKVKA-SRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNG 619
            |.||..:....::||||..:|:...:|:.. ..:|||....|||.::..:..:....|.|...||
  Fly  1126 HPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMDIRVFHRTRRRIFNACDKLNG 1190

Human   620 GCSHLCFFTPHATRCGCPIGLELLSDMKTCIV-PEAFLVFTSRAAIHRISLETNN-NDVAIPLTG 682
            ||||||...|.:..|.|.:|::|..|..||.. |..:::|..|..|.:|||:.:: .||.:||..
  Fly  1191 GCSHLCLLNPTSYTCACTVGVQLKEDRHTCSEGPTQYILFAHRIDIRQISLDFDHLIDVVLPLPP 1255

Human   683 VKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTG 747
            :..|.|||.|....:|||:|.....|..:..:|..|:.:|...|:.|:|:.||.:|:.:||||.|
  Fly  1256 ISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLENPDGLVVDSIGRTIYWADAG 1320

Human   748 TNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVD-K 811
            .:.||||.|||..|.|:.::||::||.||||...|.::||:||...:|.|:.:||.....:|. .
  Fly  1321 RHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRKIERSHLDGNERSRIVTAN 1385

Human   812 VGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWN--- 873
            :|..|.|::|...:|:||.|.....|:|.:..|.:|.:|...|.||:.|....|.||||||.   
  Fly  1386 LGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQRKLIMSSLHHPYALALSDDNIYWTDWKSKA 1450

Human   874 LHSIERADKTSGRNRTLIQGHLDFVMDI-LVFHSSRQDGL-NDCMHNNGQCGQLCLAIPGGHRCG 936
            ||..||.:.::.|:   |..::|.:||| :::.:..|..: |.|.:|||.|..|||..|.|:.|.
  Fly  1451 LHMTERRNISAKRD---IITNIDGLMDIKIIYQNQNQSTMKNACGNNNGNCSHLCLRNPSGYSCQ 1512

Human   937 CASHYTL-DPSSRNC-SPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKF 999
            |.....| ..|:..| :.|..:||.:.:|.|..:..:.....|::||::|:.....:||......
  Fly  1513 CPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDVVLPINGVHGAVVLDYHYRKNL 1577

Human  1000 IYWVD------GRQNIKRAKDD----GTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEAT 1054
            :::.|      .|.|:....:.    ||.  |||           |:.:::|..:..|:|:....
  Fly  1578 LFFADVNLDVIRRVNLLNLTESKVIVGTD--VLT-----------PNGIAVDWIADNLYWSDTDR 1629

Human  1055 NTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTG 1119
            ..|.|.||.|.....::..:...||:::|:.::.||::::... .|||||:.|||:.|.|:.|:|
  Fly  1630 KLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWSS-PAKIERSYLDGSNRTVIITSG 1693

Human  1120 LIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIV----QPLGLTILGKHLYWID 1180
            :..|..|.:|.|..:|.|.||....|...|.:|..|.|     ||    .|.|||:....::|.|
  Fly  1694 IGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQT-----IVPYAPHPFGLTLFENSIFWTD 1753

Human  1181 RQQQMIERVEKTTG-------DKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICI 1238
            ...:.:.|.:|...       :.|..:.|.:    .|.|| .:|.:..|.:.||:|||||:|:|:
  Fly  1754 WYNKSVYRSQKLARSGYGNPFEVRDALSGAL----DIRAV-SLSRQPKSVNHCAQDNGGCTHLCL 1813

Human  1239 AKG-DGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEE 1302
            .:. |..  |:|               |....|...||:......:......|...|..|:|.::
  Fly  1814 NRNVDYV--CAC---------------PDVMDPKDVACSIKPKVLVHANLENDQLLEYSDESTDD 1861

Human  1303 GCP 1305
            ..|
  Fly  1862 STP 1864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP5XP_011543331.1 YncE 34..223 CDD:442618 83/178 (47%)
LY 111..151 CDD:214531 20/39 (51%)
Ldl_recept_b 172..212 CDD:459654 20/39 (51%)
LY 196..238 CDD:214531 22/41 (54%)
LY 239..273 CDD:214531 18/33 (55%)
FXa_inhibition 308..345 CDD:464251 17/40 (43%)
LY 375..415 CDD:214531 14/39 (36%)
LY 417..459 CDD:214531 19/41 (46%)
LY 460..503 CDD:214531 20/42 (48%)
LY 504..546 CDD:214531 15/41 (37%)
LY 547..580 CDD:214531 10/32 (31%)
FXa_inhibition 614..649 CDD:464251 15/34 (44%)
NHL 694..887 CDD:302697 74/196 (38%)
LY 719..761 CDD:214531 19/41 (46%)
NHL repeat 729..765 CDD:271320 19/35 (54%)
LY 762..805 CDD:214531 18/42 (43%)
NHL repeat 772..811 CDD:271320 16/39 (41%)
NHL repeat 856..880 CDD:271320 13/26 (50%)
FXa_inhibition 915..950 CDD:464251 14/35 (40%)
LY 979..1018 CDD:214531 9/48 (19%)
LY 1069..1112 CDD:214531 13/42 (31%)
LY 1113..1155 CDD:214531 14/41 (34%)
FXa_inhibition 1226..1262 CDD:464251 12/36 (33%)
Ldl_recept_a 1267..1304 CDD:395011 7/36 (19%)
LDLa 1307..1341 CDD:238060
LDLa 1345..1379 CDD:238060
Lrp4NP_727914.1 LDLa 267..301 CDD:238060
LDLa 306..340 CDD:238060
LDLa 347..390 CDD:238060
LDLa 397..431 CDD:238060
LDLa 442..476 CDD:238060
LDLa 480..521 CDD:238060
FXa_inhibition 576..604 CDD:464251
LY 634..671 CDD:214531 17/38 (45%)
LY 680..714 CDD:214531 18/33 (55%)
LY 718..760 CDD:214531 21/41 (51%)
Ldl_recept_b 740..777 CDD:459654 20/36 (56%)
LY 761..803 CDD:214531 22/41 (54%)
LY 806..838 CDD:214531 17/31 (55%)
FXa_inhibition 882..912 CDD:464251 15/31 (48%)
LY 946..985 CDD:214531 13/38 (34%)
NHL <967..1142 CDD:302697 75/175 (43%)
LY 988..1030 CDD:214531 19/41 (46%)
NHL repeat 998..1037 CDD:271333 19/38 (50%)
NHL repeat 1038..1080 CDD:271333 20/41 (49%)
NHL repeat 1084..1119 CDD:271333 15/34 (44%)
FXa_inhibition 1185..1220 CDD:464251 15/34 (44%)
NHL 1260..>1445 CDD:302697 71/184 (39%)
NHL repeat 1260..1296 CDD:271320 11/35 (31%)
LY 1292..1334 CDD:214531 19/41 (46%)
NHL repeat 1302..1337 CDD:271320 18/34 (53%)
NHL repeat 1345..1383 CDD:271320 15/37 (41%)
FXa_inhibition <1499..1525 CDD:464251 9/25 (36%)
LY 1600..1640 CDD:214531 13/52 (25%)
LY 1643..1686 CDD:214531 13/43 (30%)
LY 1688..1729 CDD:214531 14/40 (35%)
FXa_inhibition 1801..>1825 CDD:464251 12/40 (30%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.