DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRP5 and Lrp4

DIOPT Version :9

Sequence 1:	XP_011543331.1	Gene:	LRP5 / 4041	HGNCID:	6697	Length:	1662	Species:	Homo sapiens
Sequence 2:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster

Alignment Length:	1303	Identity:	469/1303 - (35%)
Similarity:	721/1303 - (55%)	Gaps:	92/1303 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    44 LLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAV 108
            ||.|||.|:|.|.....:..:  :|.||.:|.|:||...||.::|:|||.:.||..|:|  |..|
  Fly   613 LLVANRWDIRRVTLSNNRYSA--IVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYMN--GTRV 673

Human   109 QNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGY 173
            ::|:..||.||.|:|.||:...|:||||.|.|:||:|..|..|.|:...|||:||||.:.|....
  Fly   674 RDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEAL 738

Human   174 MYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFR 238
            .:|:|||..|:||||.|||:.||:|:...:.|||||.||....|:||||||...|..:|||||.|
  Fly   739 AFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDR 803

Human   239 QKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPF 303
            .|::...|.|||||||..||:|||||.|:::.|.:|.||.:.:.:....:.||||......|||.
  Fly   804 NKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPE 868

Human   304 FHTRCEED----NGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLR-- 362
            :..||::|    .||||||||  |::....|.||.|:.|:::|:|||:.|::::|:|||.|:|
  Fly   869 YADRCQKDRRGLRGGCSHLCL--PNKTSRRCGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLR 931

Human   363 --RISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEIN 425
              |.:...|:..|:::.:|:::||:|:|:.....::||||.|...|.:|:|:||..|.:|::.:.
  Fly   932 HLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLV 996

Human   426 DPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGEN 490
            .|.|:|:||:...|||||..|:||||...||..|.:|:.|.|.:||.|.::|:.|.|:|:|||::
  Fly   997 SPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVNPIEGFMFWSDWGDD 1061

Human   491 PKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLP 555
            |.||.||:||.||..:.:..|.:|||||:|.::.|:|:.|..|..:|.:|.||:.|:.:| :.|.
  Fly  1062 PMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLENMNFDGSGRQVIL-NGLG 1125

Human   556 HIFGFTLLGDFIYWTDWQRRSIERVHKVKA-SRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNG 619
            |.||..:....::||||..:|:...:|:.. ..:|||....|||.::..:..:....|.|...||
  Fly  1126 HPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMDIRVFHRTRRRIFNACDKLNG 1190

Human   620 GCSHLCFFTPHATRCGCPIGLELLSDMKTCIV-PEAFLVFTSRAAIHRISLETNN-NDVAIPLTG 682
            ||||||...|.:..|.|.:|::|..|..||.. |..:::|..|..|.:|||:.:: .||.:||..
  Fly  1191 GCSHLCLLNPTSYTCACTVGVQLKEDRHTCSEGPTQYILFAHRIDIRQISLDFDHLIDVVLPLPP 1255

Human   683 VKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTG 747
            :..|.|||.|....:|||:|.....|..:..:|..|:.:|...|:.|:|:.||.:|:.:||||.|
  Fly  1256 ISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLENPDGLVVDSIGRTIYWADAG 1320

Human   748 TNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVD-K 811
            .:.||||.|||..|.|:.::||::||.||||...|.::||:||...:|.|:.:||.....:|. .
  Fly  1321 RHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRKIERSHLDGNERSRIVTAN 1385

Human   812 VGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWN--- 873
            :|..|.|::|...:|:||.|.....|:|.:..|.:|.:|...|.||:.|....|.||||||.
  Fly  1386 LGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQRKLIMSSLHHPYALALSDDNIYWTDWKSKA 1450

Human   874 LHSIERADKTSGRNRTLIQGHLDFVMDI-LVFHSSRQDGL-NDCMHNNGQCGQLCLAIPGGHRCG 936
            ||..||.:.::.|:   |..::|.:||| :::.:..|..: |.|.:|||.|..|||..|.|:.|.
  Fly  1451 LHMTERRNISAKRD---IITNIDGLMDIKIIYQNQNQSTMKNACGNNNGNCSHLCLRNPSGYSCQ 1512

Human   937 CASHYTL-DPSSRNC-SPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKF 999
            |.....| ..|:..| :.|..:||.:.:|.|..:..:.....|::||::|:.....:||......
  Fly  1513 CPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDVVLPINGVHGAVVLDYHYRKNL 1577

Human  1000 IYWVD------GRQNIKRAKDD----GTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEAT 1054
            :::.|      .|.|:....:.    ||.  |||           |:.:::|..:..|:|:....
  Fly  1578 LFFADVNLDVIRRVNLLNLTESKVIVGTD--VLT-----------PNGIAVDWIADNLYWSDTDR 1629

Human  1055 NTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTG 1119
            ..|.|.||.|.....::..:...||:::|:.::.||::::... .|||||:.|||:.|.|:.|:|
  Fly  1630 KLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWSS-PAKIERSYLDGSNRTVIITSG 1693

Human  1120 LIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIV----QPLGLTILGKHLYWID 1180
            :..|..|.:|.|..:|.|.||....|...|.:|..|.|     ||    .|.|||:....::|.|
  Fly  1694 IGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQT-----IVPYAPHPFGLTLFENSIFWTD 1753

Human  1181 RQQQMIERVEKTTG-------DKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICI 1238
            ...:.:.|.:|...       :.|..:.|.:    .|.|| .:|.:..|.:.||:|||||:|:|:
  Fly  1754 WYNKSVYRSQKLARSGYGNPFEVRDALSGAL----DIRAV-SLSRQPKSVNHCAQDNGGCTHLCL 1813

Human  1239 AKG-DGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEE 1302
            .:. |..  |:|               |....|...||:......:......|...|..|:|.::
  Fly  1814 NRNVDYV--CAC---------------PDVMDPKDVACSIKPKVLVHANLENDQLLEYSDESTDD 1861

Human  1303 GCP 1305
            ..|
  Fly  1862 STP 1864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP5	XP_011543331.1	NHL	<46..>178	CDD:302697	56/131 (43%)
		NHL repeat	74..113	CDD:271320	17/38 (45%)
		LY	111..151	CDD:214531	20/39 (51%)
		NHL repeat	116..157	CDD:271320	20/40 (50%)
		Ldl_recept_b	172..212	CDD:278487	20/39 (51%)
		LY	196..238	CDD:214531	22/41 (54%)
		FXa_inhibition	308..345	CDD:291342	17/40 (43%)
		LY	375..415	CDD:214531	14/39 (36%)
		LY	417..459	CDD:214531	19/41 (46%)
		LY	460..503	CDD:214531	20/42 (48%)
		LY	504..546	CDD:214531	15/41 (37%)
		LY	547..580	CDD:214531	10/32 (31%)
		FXa_inhibition	614..649	CDD:291342	15/34 (44%)
		NHL	694..887	CDD:302697	74/196 (38%)
		LY	719..761	CDD:214531	19/41 (46%)
		NHL repeat	729..765	CDD:271320	19/35 (54%)
		NHL repeat	772..811	CDD:271320	16/39 (41%)
		NHL repeat	856..880	CDD:271320	13/26 (50%)
		FXa_inhibition	915..950	CDD:291342	14/35 (40%)
		LY	979..1018	CDD:214531	9/48 (19%)
		LY	1069..1112	CDD:214531	13/42 (31%)
		LY	1113..1155	CDD:214531	14/41 (34%)
		FXa_inhibition	1226..1262	CDD:291342	12/36 (33%)
		Ldl_recept_a	1267..1304	CDD:278486	7/36 (19%)
		LDLa	1307..1341	CDD:238060
		LDLa	1345..1379	CDD:238060
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060
		LDLa	306..340	CDD:238060
		LDLa	347..390	CDD:238060
		LDLa	397..431	CDD:238060
		LDLa	442..476	CDD:238060
		LDLa	480..521	CDD:238060
		FXa_inhibition	576..604	CDD:291342
		LY	634..671	CDD:214531	17/38 (45%)
		NHL	<656..793	CDD:302697	68/138 (49%)
		LY	680..714	CDD:214531	18/33 (55%)
		NHL repeat	681..722	CDD:271320	20/40 (50%)
		NHL repeat	726..760	CDD:271320	17/33 (52%)
		LY	761..803	CDD:214531	22/41 (54%)
		NHL repeat	769..793	CDD:271320	14/23 (61%)
		FXa_inhibition	882..912	CDD:291342	15/31 (48%)
		LY	946..985	CDD:214531	13/38 (34%)
		NHL	<967..1142	CDD:302697	75/175 (43%)
		LY	988..1030	CDD:214531	19/41 (46%)
		NHL repeat	998..1037	CDD:271320	19/38 (50%)
		NHL repeat	1038..1080	CDD:271320	20/41 (49%)
		NHL repeat	1084..1119	CDD:271320	15/34 (44%)
		FXa_inhibition	1185..1220	CDD:291342	15/34 (44%)
		NHL	1260..>1445	CDD:302697	71/184 (39%)
		NHL repeat	1260..1296	CDD:271320	11/35 (31%)
		NHL repeat	1302..1337	CDD:271320	18/34 (53%)
		NHL repeat	1345..1383	CDD:271320	15/37 (41%)
		FXa_inhibition	<1499..1525	CDD:291342	9/25 (36%)
		LY	1600..1640	CDD:214531	13/52 (25%)
		LY	1643..1686	CDD:214531	13/43 (30%)
		LY	1688..1729	CDD:214531	14/40 (35%)
		FXa_inhibition	1801..>1825	CDD:291342	12/40 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I11038
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D121310at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720