DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP5 and yl

DIOPT Version :10

Sequence 1:XP_011543331.1 Gene:LRP5 / 4041 HGNCID:6697 Length:1662 Species:Homo sapiens
Sequence 2:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster


Alignment Length:1284 Identity:304/1284 - (23%)
Similarity:465/1284 - (36%) Gaps:385/1284 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   308 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKA---GAEE---VLLLARRTDLRRISL 366
            |:|.:..||..|  ..:...|.|.|..|..|..:.|||:|   |::|   :||...:..:..:.|
  Fly   352 CKEQDDLCSQGC--ENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHL 414

Human   367 DTPDFTDIVLQV-DDIRHAIAIDYDPLEGYVYWTD--DEVRAIRRAYLDGSGAQTLVNTEINDPD 428
            ...:..:.|.|| .::...|.:.||  ..::|||:  :|..:|.:|..|||.|:.|:.:.::.|:
  Fly   415 REDNVRNHVYQVAGNLSKVIGVAYD--GSHIYWTNIQNEAESIVKANGDGSNAEILLTSGLDAPE 477

Human   429 GIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKI 493
            .:||||:.:|:|::|.....|.|...:|.:..:||::|:.:||::|:.|..|||:||||||.|.|
  Fly   478 DLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMI 542

Human   494 ECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIF 558
            ..|::||...|.:|:.::.||||:|||:.:.::||.|||...::.:..|||.|||:|:..|.|.:
  Fly   543 GRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHPY 607

Human   559 GFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSH 623
            |..:..|.:||:||..:|:...||.......|:.:...:..:...:.|| ...:|....|..|||
  Fly   608 GLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTIYAVHIYHPAK-QPNSPHGCENATCSH 671

Human   624 LCFFTP-----HATRCGCPIGLELLSDMKTCIVPE----------AFLVFTSRAAI--HRISLET 671
            ||....     |:  |.||.|:.|..|.:.|::.|          ..|:.....|.  |::|   
  Fly   672 LCLLAEPEIGGHS--CACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGRHQVS--- 731

Human   672 NNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEH----VVEFGLDYPEGM 732
              ....:|        .|..::..|.|..:.:......|..:......|    :|...|.....:
  Fly   732 --KSYTLP--------CLINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSAL 786

Human   733 AVDWMGKNLYWADTGTNRIEVARLDGQFRQVL-VWRDLDNPRSLALDPTKGYIYWT--------- 787
            |.|.:.:|||||||....|||..|..:.|.:: .:...:.|..|.:.|.:||:|..         
  Fly   787 AFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYVVLKAKRHSHI 851

Human   788 ---EWGGKPRIVRAFMD--GTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER 847
               ...||...|..|.|  |.:.:.||          .||..|.::|:|.|...|..||......
  Fly   852 DKIPLSGKGEQVHVFEDDLGDDDIKLV----------TDYETQTIFWSDSDLGRISYSNYRVPHS 906

Human   848 VVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMD------------ 900
            .:....|..|:.|......::|.:.....|....|::...|.:|.     :|:            
  Fly   907 QIFRGKLRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVID-----IMEKDDPAAIMPYVP 966

Human   901 -------ILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHR-CGCASHYTL-DPSSRNCSPPTTF 956
                   .|...|......:.|...||.|..:|:.....|. |.|.:.:.. |..:|.|      
  Fly   967 VATPNGIPLAASSPVGQESHPCQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTC------ 1025

Human   957 LLFSQKSAISRMIPDDQ-HSPDLILPLH---GLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGT 1017
                    :..:..:.: ||.:.:...|   |.|:.              ||....:...::...
  Fly  1026 --------VEALDCEFRCHSGECLTMNHRCNGRRDC--------------VDNSDEMNCDEEHRR 1068

Human  1018 QPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIV 1082
            :|.||.|.:|                     :.|.          |||.               .
  Fly  1069 KPKVLCSPNQ---------------------FACH----------SGEQ---------------C 1087

Human  1083 VNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIES 1147
            |:.||                                                           .
  Fly  1088 VDKER-----------------------------------------------------------R 1093

Human  1148 CDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHA 1212
            ||    ||....|.:                   .:|..|:.:|:          :..|   :| 
  Fly  1094 CD----NRKDCHDHS-------------------DEQHCEKFDKS----------KKCH---VH- 1121

Human  1213 VEEVSLEEFSAHPCARDNGGC---SHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFA 1274
                      .|.|  |||.|   |.:|    |||..|...      .:.|.|.....|.|..|.
  Fly  1122 ----------QHGC--DNGKCVDSSLVC----DGTNDCGDN------SDELLCEATSRCEPGMFQ 1164

Human  1275 CATGEIDCIPGAWRCDGFPECDDQSDEEGCPV---CSAAQFPCARGQCVDLRLRCDGEADCQDRS 1336
            |.:|  .||.|:|.|||..:|.|.|||....|   |......|..|||:|..|.|||..||.|:|
  Fly  1165 CGSG--SCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQRCLLGQCLDRSLVCDGHNDCGDKS 1227

Human  1337 DEADCDA---------------------ICLPN--------------------------QFRCAS 1354
            ||.:|..                     ||||:                          :|:|.|
  Fly  1228 DELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDEADCGDVCSIYEFKCRS 1292

Human  1355 G-QCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDS-----PAHSSAIGPVIGIILSLFVMGGVY 1413
            | :|:..:.:||...||.||||||.||:.|...:.|     ...|.:..|.:             
  Fly  1293 GRECIRREFRCDGQKDCGDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHL------------- 1344

Human  1414 FVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIAC 1462
            |.||...|...:.....||.              ...|...||....||
  Fly  1345 FDCQDGECVDLSRVCNNFPD--------------CTNGHDEGPKCATAC 1379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP5XP_011543331.1 YncE 34..223 CDD:442618
LY 111..151 CDD:214531
Ldl_recept_b 172..212 CDD:459654
LY 196..238 CDD:214531
LY 239..273 CDD:214531
FXa_inhibition 308..345 CDD:464251 11/36 (31%)
LY 375..415 CDD:214531 14/42 (33%)
LY 417..459 CDD:214531 12/41 (29%)
LY 460..503 CDD:214531 21/42 (50%)
LY 504..546 CDD:214531 17/41 (41%)
LY 547..580 CDD:214531 12/32 (38%)
FXa_inhibition 614..649 CDD:464251 13/39 (33%)
NHL 694..887 CDD:302697 49/211 (23%)
LY 719..761 CDD:214531 16/45 (36%)
NHL repeat 729..765 CDD:271320 14/36 (39%)
LY 762..805 CDD:214531 12/57 (21%)
NHL repeat 772..811 CDD:271320 14/52 (27%)
NHL repeat 856..880 CDD:271320 4/23 (17%)
FXa_inhibition 915..950 CDD:464251 10/36 (28%)
LY 979..1018 CDD:214531 5/41 (12%)
LY 1069..1112 CDD:214531 3/42 (7%)
LY 1113..1155 CDD:214531 2/41 (5%)
FXa_inhibition 1226..1262 CDD:464251 12/38 (32%)
Ldl_recept_a 1267..1304 CDD:395011 17/36 (47%)
LDLa 1307..1341 CDD:238060 16/33 (48%)
LDLa 1345..1379 CDD:238060 18/60 (30%)
ylNP_996433.1 LDLa 90..124 CDD:238060
LDLa 131..166 CDD:238060
LDLa 184..216 CDD:238060
LDLa 227..262 CDD:238060
LDLa 271..302 CDD:238060
FXa_inhibition 352..387 CDD:464251 11/36 (31%)
Ldl_recept_b 442..483 CDD:459654 14/40 (35%)
LY 466..508 CDD:214531 12/41 (29%)
Ldl_recept_b 529..569 CDD:459654 21/39 (54%)
LY 553..595 CDD:214531 17/41 (41%)
LY 596..637 CDD:214531 14/40 (35%)
FXa_inhibition 669..700 CDD:464251 12/32 (38%)
LY 774..815 CDD:214531 15/40 (38%)
LDLa 1032..1062 CDD:238060 7/43 (16%)
LDLa 1074..1109 CDD:238060 15/162 (9%)
LDLa 1118..1152 CDD:238060 15/59 (25%)
LDLa 1157..1189 CDD:197566 15/33 (45%)
LDLa 1198..1232 CDD:238060 16/33 (48%)
LDLa 1243..1279 CDD:238060 4/35 (11%)
LDLa 1283..1318 CDD:238060 15/34 (44%)
LDLa 1340..1371 CDD:197566 8/57 (14%)
FXa_inhibition 1388..1416 CDD:464251
EGF_CA 1418..1452 CDD:214542
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.