| Sequence 1: | XP_011543331.1 | Gene: | LRP5 / 4041 | HGNCID: | 6697 | Length: | 1662 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_996433.1 | Gene: | yl / 32367 | FlyBaseID: | FBgn0004649 | Length: | 1984 | Species: | Drosophila melanogaster |
| Alignment Length: | 1284 | Identity: | 304/1284 - (23%) |
|---|---|---|---|
| Similarity: | 465/1284 - (36%) | Gaps: | 385/1284 - (29%) |
- Green bases have known domain annotations that are detailed below.
|
Human 308 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKA---GAEE---VLLLARRTDLRRISL 366
Human 367 DTPDFTDIVLQV-DDIRHAIAIDYDPLEGYVYWTD--DEVRAIRRAYLDGSGAQTLVNTEINDPD 428
Human 429 GIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKI 493
Human 494 ECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIF 558
Human 559 GFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSH 623
Human 624 LCFFTP-----HATRCGCPIGLELLSDMKTCIVPE----------AFLVFTSRAAI--HRISLET 671
Human 672 NNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEH----VVEFGLDYPEGM 732
Human 733 AVDWMGKNLYWADTGTNRIEVARLDGQFRQVL-VWRDLDNPRSLALDPTKGYIYWT--------- 787
Human 788 ---EWGGKPRIVRAFMD--GTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER 847
Human 848 VVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMD------------ 900
Human 901 -------ILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHR-CGCASHYTL-DPSSRNCSPPTTF 956
Human 957 LLFSQKSAISRMIPDDQ-HSPDLILPLH---GLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGT 1017
Human 1018 QPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIV 1082
Human 1083 VNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIES 1147
Human 1148 CDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHA 1212
Human 1213 VEEVSLEEFSAHPCARDNGGC---SHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFA 1274
Human 1275 CATGEIDCIPGAWRCDGFPECDDQSDEEGCPV---CSAAQFPCARGQCVDLRLRCDGEADCQDRS 1336
Human 1337 DEADCDA---------------------ICLPN--------------------------QFRCAS 1354
Human 1355 G-QCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDS-----PAHSSAIGPVIGIILSLFVMGGVY 1413
Human 1414 FVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIAC 1462 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LRP5 | XP_011543331.1 | NHL | <46..>178 | CDD:302697 | |
| NHL repeat | 74..113 | CDD:271320 | |||
| LY | 111..151 | CDD:214531 | |||
| NHL repeat | 116..157 | CDD:271320 | |||
| Ldl_recept_b | 172..212 | CDD:278487 | |||
| LY | 196..238 | CDD:214531 | |||
| FXa_inhibition | 308..345 | CDD:291342 | 11/36 (31%) | ||
| LY | 375..415 | CDD:214531 | 14/42 (33%) | ||
| LY | 417..459 | CDD:214531 | 12/41 (29%) | ||
| LY | 460..503 | CDD:214531 | 21/42 (50%) | ||
| LY | 504..546 | CDD:214531 | 17/41 (41%) | ||
| LY | 547..580 | CDD:214531 | 12/32 (38%) | ||
| FXa_inhibition | 614..649 | CDD:291342 | 13/39 (33%) | ||
| NHL | 694..887 | CDD:302697 | 49/211 (23%) | ||
| LY | 719..761 | CDD:214531 | 16/45 (36%) | ||
| NHL repeat | 729..765 | CDD:271320 | 14/36 (39%) | ||
| NHL repeat | 772..811 | CDD:271320 | 14/52 (27%) | ||
| NHL repeat | 856..880 | CDD:271320 | 4/23 (17%) | ||
| FXa_inhibition | 915..950 | CDD:291342 | 10/36 (28%) | ||
| LY | 979..1018 | CDD:214531 | 5/41 (12%) | ||
| LY | 1069..1112 | CDD:214531 | 3/42 (7%) | ||
| LY | 1113..1155 | CDD:214531 | 2/41 (5%) | ||
| FXa_inhibition | 1226..1262 | CDD:291342 | 12/38 (32%) | ||
| Ldl_recept_a | 1267..1304 | CDD:278486 | 17/36 (47%) | ||
| LDLa | 1307..1341 | CDD:238060 | 16/33 (48%) | ||
| LDLa | 1345..1379 | CDD:238060 | 18/60 (30%) | ||
| yl | NP_996433.1 | LDLa | 90..124 | CDD:238060 | |
| LDLa | 131..166 | CDD:238060 | |||
| LDLa | 184..216 | CDD:238060 | |||
| LDLa | 227..262 | CDD:238060 | |||
| LDLa | 271..302 | CDD:238060 | |||
| FXa_inhibition | 352..387 | CDD:291342 | 11/36 (31%) | ||
| Ldl_recept_b | 442..482 | CDD:278487 | 13/39 (33%) | ||
| LY | 466..508 | CDD:214531 | 12/41 (29%) | ||
| Ldl_recept_b | 529..569 | CDD:278487 | 21/39 (54%) | ||
| LY | 553..595 | CDD:214531 | 17/41 (41%) | ||
| LY | 596..637 | CDD:214531 | 14/40 (35%) | ||
| FXa_inhibition | 669..700 | CDD:291342 | 12/32 (38%) | ||
| LY | 774..815 | CDD:214531 | 15/40 (38%) | ||
| LDLa | 1032..1062 | CDD:238060 | 7/43 (16%) | ||
| LDLa | 1074..1109 | CDD:238060 | 15/162 (9%) | ||
| LDLa | 1118..1152 | CDD:238060 | 15/59 (25%) | ||
| LDLa | 1157..1189 | CDD:197566 | 15/33 (45%) | ||
| LDLa | 1198..1232 | CDD:238060 | 16/33 (48%) | ||
| LDLa | 1243..1279 | CDD:238060 | 4/35 (11%) | ||
| LDLa | 1283..1318 | CDD:238060 | 15/34 (44%) | ||
| LDLa | 1340..1371 | CDD:197566 | 8/57 (14%) | ||
| FXa_inhibition | 1388..1416 | CDD:291342 | |||
| EGF_CA | 1418..1452 | CDD:214542 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG1215 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 1 | 0.900 | - | - | OOG6_100345 | |
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.710 | |||||