DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRP5 and lrp5

DIOPT Version :9

Sequence 1:	XP_011543331.1	Gene:	LRP5 / 4041	HGNCID:	6697	Length:	1662	Species:	Homo sapiens
Sequence 2:	XP_002941689.1	Gene:	lrp5 / 100491803	XenbaseID:	XB-GENE-485117	Length:	1603	Species:	Xenopus tropicalis

Alignment Length:	1641	Identity:	1323/1641 - (80%)
Similarity:	1461/1641 - (89%)	Gaps:	53/1641 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    24 CLSSRNGKEEAAQYFPASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYW 88
            ||:|..|          |||||||||||||||||||.||||.:|||||||||||||.:|:|.:||
Frog    14 CLASSWG----------SPLLLFANRRDVRLVDAGGTKLESVVVVSGLEDAAAVDFLYSQGVIYW 68

Human    89 TDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKV 153
            ||||||:||||..||: :.:|.||||||||||||||||:||||||||||||||||.|||||.|||
Frog    69 TDVSEESIKQTLYNQS-SNLQTVVISGLVSPDGLACDWIGKKLYWTDSETNRIEVGNLNGTYRKV 132

Human   154 LFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKL 218
            |||||||||||||||||||||||||||:||||||||||||.||:|||:||||||||||||:||||
Frog   133 LFWQDLDQPRAIALDPAHGYMYWTDWGDTPRIERAGMDGSMRKVIVDTDIYWPNGLTIDLDEQKL 197

Human   219 YWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEI 283
            ||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||.||:||
Frog   198 YWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLAGDTLYWTDWQTRSIHACNKRTGEKRREI 262

Human   284 LSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAG 348
            ||:|||||||||.|:||||:|.|.|:|.||||||||||||.||||:|.|||||||..:|:|||.|
Frog   263 LSSLYSPMDIQVFSKERQPYFPTPCDESNGGCSHLCLLSPREPFYSCTCPTGVQLTQDGKTCKTG 327

Human   349 AEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDG 413
            |::||||||||||||||||.|||||||||:|||||||||||||:|||:|||||||:|||||||||
Frog   328 ADDVLLLARRTDLRRISLDMPDFTDIVLQIDDIRHAIAIDYDPVEGYIYWTDDEVKAIRRAYLDG 392

Human   414 SGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPV 478
            |||||||.||:..||||||||||||||||||||||||||||||||||||:||:|||||||.|||:
Frog   393 SGAQTLVTTEVQHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILISENLDEPRAIVLHPL 457

Human   479 MGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDG 543
            .|.|||||||||||||.|.|||.||.||||:|||||||||||||:||||||||||||||||||||
Frog   458 TGYMYWTDWGENPKIESAYLDGSERMVLVNSSLGWPNGLALDLQDGKLYWGDAKTDKIEVINVDG 522

Human   544 TKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKV 608
            :.|:||||||||||||||||||:|||||||||||||||||:|||::|||||||||||||.:|:..
Frog   523 SNRKTLLEDKLPHIFGFTLLGDYIYWTDWQRRSIERVHKVRASREIIIDQLPDLMGLKAASVSNT 587

Human   609 VGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNN 673
            .|||||||.||||||||||:|...||.|||||||||||:|||:|||||||||||.||||||||||
Frog   588 FGTNPCADNNGGCSHLCFFSPRGVRCSCPIGLELLSDMRTCIIPEAFLVFTSRATIHRISLETNN 652

Human   674 NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMG 738
            |||||||||||||||||||||:|.:||||::|||||||||||||||||:||||||||||||||||
Frog   653 NDVAIPLTGVKEASALDFDVSDNRLYWTDITLKTISRAFMNGSSVEHVIEFGLDYPEGMAVDWMG 717

Human   739 KNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGT 803
            |||||:|||||||||:||||.:||||||:||||||||||||.|||:||||||||||||||:||||
Frog   718 KNLYWSDTGTNRIEVSRLDGLYRQVLVWKDLDNPRSLALDPAKGYMYWTEWGGKPRIVRAYMDGT 782

Human   804 NCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIY 868
            |.:.|||||||||||||||||||||||||||||||||||||.|||:|||||||||||||||||||
Frog   783 NSIILVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGAERVIIADDLPHPFGLTQYSDYIY 847

Human   869 WTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGH 933
            ||||||||||||||.:|.||||||.|||||||||||||||||||||||.|||.|.|||||:|.|:
Frog   848 WTDWNLHSIERADKLNGNNRTLIQDHLDFVMDILVFHSSRQDGLNDCMQNNGHCSQLCLAVPKGY 912

Human   934 RCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDK 998
            :|.|:||||||.::||||||:.|||||||:||:||:.|:|.|||:.||:||||||||:.||||||
Frog   913 KCSCSSHYTLDSNNRNCSPPSNFLLFSQKTAINRMLLDEQQSPDITLPIHGLRNVKAVSYDPLDK 977

Human   999 FIYWVDGRQN-IKRAKDDGTQPFVLTSL-SQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHR 1061
            .||||||||| |||||||||||||:.|. :|.|.|::|||||||||||.||:||||.|||||.::
Frog   978 LIYWVDGRQNIIKRAKDDGTQPFVVVSTPNQSQTPEKQPHDLSIDIYSHTLYWTCEGTNTINANK 1042

Human  1062 LSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVAL 1126
            |:||::|||||||.||||||.||||||||||||||:|:.||||||.|||||||||:|||||||||
Frog  1043 LNGESIGVVLRGDHDKPRAIAVNAERGYLYFTNMQERSPKIERAAFDGTEREVLFSTGLIRPVAL 1107

Human  1127 VVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEK 1191
            ||||.||||||||||||||||.|||||||:||||:||:||:||||||.||||||:||||||||||
Frog  1108 VVDNKLGKLFWVDADLKRIESSDLSGANRVTLEDSNILQPMGLTILGDHLYWIDKQQQMIERVEK 1172

Human  1192 TTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLL 1256
            |.|.:||:||||:||.|||||||.|.:.|||||||:|:|||||||||.|||||||||||||||||
Frog  1173 TNGIRRTKIQGRIAHPTGIHAVESVDMNEFSAHPCSRNNGGCSHICITKGDGTPRCSCPVHLVLL 1237

Human  1257 QNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVD 1321
            ||||||||||||||:||.||||:|||||.|||||||.||||.||||.|||||:.||.|.:|||:|
Frog  1238 QNLLTCGEPPTCSPEQFTCATGDIDCIPMAWRCDGFSECDDNSDEENCPVCSSNQFQCEKGQCID 1302

Human  1322 LRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPS 1386
            .|.:|:||.||||:|||.|||:||||:|||||:|||:::.||||:||||.|.||||:|:  ||||
Frog  1303 ARQKCNGEIDCQDKSDELDCDSICLPDQFRCANGQCIMMSQQCDTFPDCSDSSDELICD--KPPS 1365

Human  1387 DDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGG 1451
            :.:|:||||||||||||||:|||||:|||||||||.||.|.||||||||:|||||||||||....
Frog  1366 EKTPSHSSAIGPVIGIILSVFVMGGLYFVCQRVVCHRYTGPNGPFPHEYISGTPHVPLNFITTRS 1430

Human  1452 SQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPGLGSGCMLSRM 1516
            ||...:|||:.||.|:.|:|:|||..|.|||||||||||||||||||||||||
Frog  1431 SQPNTYTGISYGKPMIGSMSIMGGSSGAPLYDRNHVTGASSSSSSSTKATLYP------------ 1483

Human  1517 ALETHISPTPFGKLHVGLGCRQWHLWKILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIR 1581
                                      :|||||||||||.||||.::|||||.|:|.|.||||:||
Frog  1484 --------------------------QILNPPPSPATDRSLYNTEVFYSSNSPSTTRSYRPYLIR 1522

Human  1582 GMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERS 1646
            |:||||||||||||||||:.|||||:|||:|||||||||||||||.|||:|||:||||||.||||
Frog  1523 GIAPPTTPCSTDVCDSDYTTSRWKANKYYMDLNSDSDPYPPPPTPRSQYMSAEESCPPSPTTERS 1587

Human  1647 YFHLFPPPPSPCTDSS 1662
            ||||:|||||||||||
Frog  1588 YFHLYPPPPSPCTDSS 1603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP5	XP_011543331.1	NHL	<46..>178	CDD:302697	111/131 (85%)
		NHL repeat	74..113	CDD:271320	24/38 (63%)
		LY	111..151	CDD:214531	37/39 (95%)
		NHL repeat	116..157	CDD:271320	37/40 (93%)
		Ldl_recept_b	172..212	CDD:278487	35/39 (90%)
		LY	196..238	CDD:214531	38/41 (93%)
		FXa_inhibition	308..345	CDD:291342	27/36 (75%)
		LY	375..415	CDD:214531	35/39 (90%)
		LY	417..459	CDD:214531	37/41 (90%)
		LY	460..503	CDD:214531	33/42 (79%)
		LY	504..546	CDD:214531	37/41 (90%)
		LY	547..580	CDD:214531	30/32 (94%)
		FXa_inhibition	614..649	CDD:291342	27/34 (79%)
		NHL	694..887	CDD:302697	171/192 (89%)
		LY	719..761	CDD:214531	37/41 (90%)
		NHL repeat	729..765	CDD:271320	31/35 (89%)
		NHL repeat	772..811	CDD:271320	32/38 (84%)
		NHL repeat	856..880	CDD:271320	23/23 (100%)
		FXa_inhibition	915..950	CDD:291342	22/34 (65%)
		LY	979..1018	CDD:214531	33/39 (85%)
		LY	1069..1112	CDD:214531	36/42 (86%)
		LY	1113..1155	CDD:214531	38/41 (93%)
		FXa_inhibition	1226..1262	CDD:291342	32/35 (91%)
		Ldl_recept_a	1267..1304	CDD:278486	30/36 (83%)
		LDLa	1307..1341	CDD:238060	20/33 (61%)
		LDLa	1345..1379	CDD:238060	24/33 (73%)
lrp5	XP_002941689.1	LY	88..130	CDD:214531	38/41 (93%)
		LY	131..174	CDD:214531	41/42 (98%)
		LY	175..217	CDD:214531	38/41 (93%)
		LY	218..252	CDD:214531	32/33 (97%)
		FXa_inhibition	287..324	CDD:373209	27/36 (75%)
		LY	354..394	CDD:214531	35/39 (90%)
		LY	396..438	CDD:214531	37/41 (90%)
		LY	439..482	CDD:214531	33/42 (79%)
		LY	484..525	CDD:214531	37/40 (93%)
		LY	526..559	CDD:214531	30/32 (94%)
		FXa_inhibition	593..628	CDD:373209	27/34 (79%)
		LY	657..697	CDD:214531	34/39 (87%)
		LY	698..740	CDD:214531	37/41 (90%)
		LY	741..783	CDD:214531	37/41 (90%)
		LY	785..826	CDD:214531	37/40 (93%)
		LY	826..867	CDD:214531	36/40 (90%)
		FXa_inhibition	894..929	CDD:373209	22/34 (65%)
		LY	958..998	CDD:214531	33/39 (85%)
		LY	1050..1093	CDD:214531	36/42 (86%)
		LY	1094..1136	CDD:214531	38/41 (93%)
		FXa_inhibition	1207..1243	CDD:373209	32/35 (91%)
		LDLa	1249..1285	CDD:238060	29/35 (83%)
		LDLa	1288..1322	CDD:238060	20/33 (61%)
		LDLa	1326..1360	CDD:238060	24/33 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	428	1.000	Domainoid score	I5253
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1746
Inparanoid	1	1.050	2841	1.000	Inparanoid score	I283
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48457
OrthoDB	1	1.010	-	-		D121310at2759
OrthoFinder	1	1.000	-	-		FOG0004181
OrthoInspector	1	1.000	-	-		oto156571
Panther	1	1.100	-	-	LDO	PTHR46513
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080