DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11249 and PYK2

DIOPT Version :9

Sequence 1:	NP_649346.1	Gene:	CG11249 / 40409	FlyBaseID:	FBgn0037115	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_014992.3	Gene:	PYK2 / 854529	SGDID:	S000005874	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	522	Identity:	93/522 - (17%)
Similarity:	201/522 - (38%)	Gaps:	100/522 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 TTPVGTDPNENRKCVELTSMTNCDLEIKHHLLGGVRCFMVNLFEGTQHDNQSLIVKLREAEISVS 189
            |:.:||...:...|..:|::....|.|          ..:|...|:...:||:|      |.:|.
Yeast    23 TSIIGTIGPKTNSCEAITALRKAGLNI----------IRLNFSHGSYEFHQSVI------ENAVK 71

  Fly   190 KELGFPVTSSVMVKISPRHQFTGGFSTQFRQEGKKCVELVQGQKVILTVDRQYSDRSNADVIYVN 254
            .|..||.....:...:...:...|     |....:.:.:....::|.|.|..:::.||..::|::
Yeast    72 SEQQFPGRPLAIALDTKGPEIRTG-----RTLNDQDLYIPVDHQMIFTTDASFANTSNDKIMYID 131

  Fly   255 ----------ARFLIVDVHPLDF--ILIGEDIQLMVRSIHADHLKGCVARGGMLYAHMPVLFPAR 307
                      .||:.||...|.|  :.|.::..|.|:::::.::   .:..|:...:..|..|.
Yeast   132 YANLTKVIVPGRFIYVDDGILSFKVLQIIDESNLRVQAVNSGYI---ASHKGVNLPNTDVDLPP- 192

  Fly   308 CRRFRISYEELEDLTFAREVGLNVVVSHIVGTPKYVDNLEHAMSAMHCDGMRLYARVVLNEVQGC 372
                 :|.::::||.|....|:::|.:..:.|.:.|.::..|:.:   :|..:   .::::::..
Yeast   193 -----LSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGS---EGQDI---KIISKIENQ 246

  Fly   373 KGELNW--AIKRYDGFLV---ELAEPATVPDIMHLCPD--AECFMQLTYAAKKPIIFDPRLLDEQ 430
            :|..|:  .::..||.::   :|......|:::.:...  |:|.:     |.||:|...::||..
Yeast   247 QGLDNFDEILEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNL-----AGKPVICATQMLDSM 306

  Fly   431 KLRVDPAHYYYTFY---------------------YPDKYVTTCPQPKGTIYFRLLQSAIFEQI- 473
            .....|.....:..                     ||...|.............:...|:::.:
Yeast   307 THNPRPTRAEVSDVGNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAHLALYDDLR 371

  Fly   474 ----SPTALANTPYCDRSHTGADSLARSVVTASIEVHAVAIVVIGVTTRMVQKISHFRPHAPILF 534
                .||:...|            :|.:...|.:|....||||:..|....:.:|.:||..||:.
Yeast   372 DATPKPTSTTET------------VAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPSCPIIL 424

  Fly   535 VS-HMRSAEDYVSIYHNVTMLPFRTKCIIAHRRNVFLKAIYALAYLVKRKIAKQNDQVILVYNYE 598
            |: |.|:|. ...:|..|....:..|.:.....:|..:..:.:.......:....|.|:.:..::
Yeast   425 VTRHARTAR-IAHLYRGVFPFLYEPKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQGFK 488

  Fly   599 DG 600
            .|
Yeast   489 GG 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11249	NP_649346.1	Pyruvate_Kinase	158..>332	CDD:304951	35/185 (19%)
CG11249	NP_649346.1	PK_C	492..594	CDD:280960	23/102 (23%)
PYK2	NP_014992.3	Pyruvate_Kinase	20..502	CDD:238178	93/522 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770