DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11249 and CDC19

DIOPT Version :9

Sequence 1:	NP_649346.1	Gene:	CG11249 / 40409	FlyBaseID:	FBgn0037115	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_009362.1	Gene:	CDC19 / 851193	SGDID:	S000000036	Length:	500	Species:	Saccharomyces cerevisiae

Alignment Length:	507	Identity:	98/507 - (19%)
Similarity:	198/507 - (39%)	Gaps:	126/507 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 GVRCFMVNLFEGTQHDNQSLIVKLREAE-------ISVSKELGFP------VTSSVMVKISPRHQ 209
            |:....:|...|:...::|:|...|::|       ::::.:...|      .|:.|...|.|.|:
Yeast    44 GLNIVRMNFSHGSYEYHKSVIDNARKSEELYPGRPLAIALDTKGPEIRTGTTTNDVDYPIPPNHE 108

  Fly   210 FTGGFSTQFRQEGKKCVELVQGQKVILTVDRQYSDRSNADVIYVN----------ARFLIVDVHP 264
                                    :|.|.|.:|:...:..::||:          .|.:.||...
Yeast   109 ------------------------MIFTTDDKYAKACDDKIMYVDYKNITKVISAGRIIYVDDGV 149

  Fly   265 LDF--ILIGEDIQLMVRSIHADHLKGCVARGGMLYAHMP---VLFPARCRRFRISYEELEDLTFA 324
            |.|  :.:.:|..|.|::::|.  |.|..:|    .::|   |..||      :|.::.|||.|.
Yeast   150 LSFQVLEVVDDKTLKVKALNAG--KICSHKG----VNLPGTDVDLPA------LSEKDKEDLRFG 202

  Fly   325 REVGLNVVVSHIVGTPKYVDNLEHAMSAMHCDGMRLYARVVLNEVQGCKGELNW--AIKRYDGFL 387
            .:.|:::|.:..:.|...|..:...:.....|     .:::: :::..:|..|:  .:|..||.:
Yeast   203 VKNGVHMVFASFIRTANDVLTIREVLGEQGKD-----VKIIV-KIENQQGVNNFDEILKVTDGVM 261

  Fly   388 V---ELAEPATVPDIMHLCPDAECFMQLTYAAKKPIIFDPRLLDEQKLRVDPAHYYYTFY----- 444
            |   :|......|:::.:   .:..:..:..|.||:|...::|:.......|.....:..
Yeast   262 VARGDLGIEIPAPEVLAV---QKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSDVGNAIL 323

  Fly   445 ----------------YPDKYVTTCPQPKGTIYFRLLQSAIFEQISPTALANTPYCD-------R 486
                            ||...|||           :.::|:   |:..|:|..|..|       :
Yeast   324 DGADCVMLSGETAKGNYPINAVTT-----------MAETAV---IAEQAIAYLPNYDDMRNCTPK 374

  Fly   487 SHTGADSLARSVVTASIEVHAVAIVVI---GVTTRMVQKISHFRPHAPILFVSHMRSAEDYVSIY 548
            ..:..:::|.|.|.|..|..|.||:|:   |.|.|:|.|   :||:.||:.|:....|..:..:|
Yeast   375 PTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSK---YRPNCPIILVTRCPRAARFSHLY 436

  Fly   549 HNVTMLPFRTKCIIAHRRNVFLKAIYALAYLVKRKIAKQNDQVILVYNYEDG 600
            ..|....|..:.:.....:|..:..:.:....:..|.|:.|..:.:..::.|
Yeast   437 RGVFPFVFEKEPVSDWTDDVEARINFGIEKAKEFGILKKGDTYVSIQGFKAG 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11249	NP_649346.1	Pyruvate_Kinase	158..>332	CDD:304951	41/201 (20%)
CG11249	NP_649346.1	PK_C	492..594	CDD:280960	27/104 (26%)
CDC19	NP_009362.1	Pyruvate_Kinase	18..500	CDD:238178	98/507 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770