DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG11249 and PKP-BETA1

DIOPT Version :9

Sequence 1:NP_649346.1 Gene:CG11249 / 40409 FlyBaseID:FBgn0037115 Length:642 Species:Drosophila melanogaster
Sequence 2:NP_200104.1 Gene:PKP-BETA1 / 835369 AraportID:AT5G52920 Length:579 Species:Arabidopsis thaliana


Alignment Length:586 Identity:106/586 - (18%)
Similarity:193/586 - (32%) Gaps:167/586 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 LDFEELSEDPCNISFEEDRWHGFFKDFQILTTPVG--TDPNENRKCVELTSM---TNCDLEIKHH 154
            ::.|.:...|.::...|::.....:..|...|.||  :.|...||...:.::   ||....|...
plant    67 VETEVIPVSPEDVPNREEQLERLLEMQQFGDTSVGMWSKPTVRRKTKIVCTVGPSTNTREMIWKL 131

  Fly   155 LLGGVRCFMVNLFEGTQHDNQSLIVKLREAEISVSKELGFPVTSSVMVKISPRHQFTGGFSTQFR 219
            ...|:....:|:..|....::.:|..::|........     |.::|:........:|..     
plant   132 AEAGMNVARMNMSHGDHASHKKVIDLVKEYNAQTKDN-----TIAIMLDTKGPEVRSGDL----- 186

  Fly   220 QEGKKCVELVQGQKVILTVDRQYSDRSNADVIYVNARFLIVDVHPLDFILI-GEDIQLMVRSIHA 283
               .:.:.|..||:...|::|..|..|   .:.||....:.||...|.:|: |..:..||:|...
plant   187 ---PQPIMLDPGQEFTFTIERGVSTPS---CVSVNYDDFVNDVEAGDMLLVDGGMMSFMVKSKTK 245

  Fly   284 DHLKGCVARGGMLYA--HMPV-----LFPARCRRFRISYEELEDLTFAREVGLNVVVSHIVGTPK 341
            |.:|..|..||.|.:  |:.|     ..|:      |:.::.||:.|..|   |.|..:.|...|
plant   246 DSVKCEVVDGGELKSRRHLNVRGKSATLPS------ITEKDWEDIKFGVE---NKVDFYAVSFVK 301

  Fly   342 YVDNLEHAMSAMHCDGMRLYARVVLNEVQGCKGELNWAIKRYDGFLVELAE----------PATV 396
            ....:......:...|..::..|.:....... .|:..|...||.:|...:          |...
plant   302 DAQVVHELKKYLQNSGADIHVIVKIESADSIP-NLHSIITASDGAMVARGDLGAELPIEEVPILQ 365

  Fly   397 PDIMHLCPDAECFMQLTYAAKKPIIFDPRLLDEQKLRVDPAHYYYTFYYPDKYVTTCPQPKGTIY 461
            .:|::||          .:..|.:|....:|:...:...|..                       
plant   366 EEIINLC----------RSMGKAVIVATNMLESMIVHPTPTR----------------------- 397

  Fly   462 FRLLQSAIFEQISPTALANTPYCDRSHTGADSLARSVVTASIE--------VHAVAI-------- 510
                     .::|..|:|       ...|||::..|..||..:        :|.||:        
plant   398 ---------AEVSDIAIA-------VREGADAVMLSGETAHGKFPLKAAGVMHTVALRTEATITS 446

  Fly   511 ----------------------------------VVIGVTTRMVQKISHFRPHAPILFVSHMRSA 541
                                              ||...|..|...:||:||...|...::.:..
plant   447 GEMPPNLGQAFKNHMSEMFAYHATMMSNTLGTSTVVFTRTGFMAILLSHYRPSGTIYAFTNEKKI 511

  Fly   542 EDYVSIYHNVTMLPFRTKCII-----AHRRNVFLKAIYALAYLVKRKIAKQNDQVILVYNYEDGT 601
            :..:::|..|        |.|     ......|..   |||.|:|:.:.|:.:::.:|   :.||
plant   512 QQRLALYQGV--------CPIYMEFTDDAEETFAN---ALATLLKQGMVKKGEEIAIV---QSGT 562

  Fly   602 K 602
            :
plant   563 Q 563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11249NP_649346.1 Pyruvate_Kinase 158..>332 CDD:304951 40/181 (22%)
PK_C 492..594 CDD:280960 27/156 (17%)
PKP-BETA1NP_200104.1 PLN02623 1..579 CDD:215334 106/586 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0469
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
32.770

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