DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11249 and PKP-ALPHA

DIOPT Version :9

Sequence 1:	NP_649346.1	Gene:	CG11249 / 40409	FlyBaseID:	FBgn0037115	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_566720.1	Gene:	PKP-ALPHA / 821870	AraportID:	AT3G22960	Length:	596	Species:	Arabidopsis thaliana

Alignment Length:	609	Identity:	110/609 - (18%)
Similarity:	215/609 - (35%)	Gaps:	140/609 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 HSGFNQ--------------------NCSSASEEELDFEELSEDPCNISFEEDRWHGFFK--DFQ 122
            ||.||:                    ..||:|....|.:..|....:.........|..|  :..
plant    21 HSQFNRPLSSISFRRFPLTTIKYTSIRASSSSSPSPDLDSSSSSSSSQVLLSPNGTGAVKSDERS 85

  Fly   123 ILTTPVGTDPNENRKCVELTSMTNCDL-------------------------EIKHHLLGGVRCF 162
            ::.|.|.||.:.    :|:.::|..:|                         :::...:||:...
plant    86 VVATAVTTDTSG----IEVDTVTEAELKENGFRSTRRTKLICTIGPATCGFEQLEALAVGGMNVA 146

  Fly   163 MVNLFEGTQHDNQSLIVKLREAEISVSKELGFPVTSSVMVKISPRHQ-FTGGFSTQFRQEGKKCV 226
            .:|:..||:..::.:|..:|.    :::|.||.|...:..:.|..|. ..||.::...::|:...
plant   147 RLNMCHGTRDWHRGVIRSVRR----LNEEKGFAVAIMMDTEGSEIHMGDLGGEASAKAEDGEVWT 207

  Fly   227 ELVQG-------QKVILTVDRQYSDRSNADVIYVN---ARFLIVDVHPLDFILIGEDIQLMVRSI 281
            ..|:.       :.:.::.|....|....|.:.|:   .||.:::       .||.|::.:...
plant   208 FTVRAFDSSRPERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIE-------KIGPDVKCLCTD- 264

  Fly   282 HADHLKGCVA--------RGGMLYAHMPVLFPARCRRFRISYEELEDLTFAREVGLNVVVSHIVG 338
                 .|.:.        |.|.|......:.|.      ||.::..|:.|....|::.:....|.
plant   265 -----PGLLLPRANLTFWRDGSLVRERNAMLPT------ISSKDWLDIDFGIAEGVDFIAVSFVK 318

  Fly   339 TPKYVDNLEHAMSAMHCDG-MRLYARVVLNEVQGCKGELNWAIKRYDGFLVELAE-PATVPDIMH 401
            :.:.:::|:..::|....| :.:.|::   |.......|...|...||.:|...: .|.:|  :.
plant   319 SAEVINHLKSYLAARSRGGEIGVIAKI---ESIDSLTNLEEIILASDGAMVARGDLGAQIP--LE 378

  Fly   402 LCPDA-ECFMQLTYAAKKPIIFDPRLLDEQ-----KLRVDPAHYYYTF----------------Y 444
            ..|.| :..:|:..|..||:|...:||:..     ..|.:.|......                .
plant   379 QVPAAQQRIVQVCRALNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRSDALMLSGESAMGQ 443

  Fly   445 YPDKYVTTCPQPKGTIYFRL----LQSAIFEQISPTALANTPYCDRSHTGADSLARSVVTASIEV 505
            :|||.:|..    .|:..|:    .:....|.: |.....:.:.|:.   ::.:..|....:..:
plant   444 FPDKALTVL----RTVSLRIERWWREEKRHESV-PLQAIGSSFSDKI---SEEICNSAAKMANNL 500

  Fly   506 HAVAIVVIGVTTRMVQKISHFRPHAPILFVSHMRSAEDYVSIYHNVTMLPFRTKCIIAHRRNVFL 570
            ...|:.|...:..|...:|..||..||...:...|....:::...  ::|||.........|  |
plant   501 GVDAVFVYTTSGHMASLVSRCRPDCPIFAFTTTTSVRRRLNLQWG--LIPFRLSFSDDMESN--L 561

  Fly   571 KAIYALAYLVKRKIAKQNDQVILV 594
            ...::|  |..|.:.|..|.||.|
plant   562 NKTFSL--LKSRGMIKSGDLVIAV 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11249	NP_649346.1	Pyruvate_Kinase	158..>332	CDD:304951	35/192 (18%)
CG11249	NP_649346.1	PK_C	492..594	CDD:280960	22/101 (22%)
PKP-ALPHA	NP_566720.1	PLN02762	93..596	CDD:215407	97/537 (18%)
PKP-ALPHA	NP_566720.1	Pyruvate_Kinase	117..584	CDD:304951	92/509 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770