Protein Alignment CG11249 and PKM

DIOPT Version :9

• Sequence 1: NP_649346.1
• Gene: CG11249 / 40409
• FlyBaseID: FBgn0037115
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_001193725.1
• Gene: PKM / 5315
• HGNCID: 9021
• Length: 605
• Species: Homo sapiens
• Alignment Length: 493
• Identity: 96/493 - (19%)
• Similarity: 202/493 - (40%)
• Gaps: 72/493 - (14%)

  Fly   151 IKHHLLGGVRCFMVNLFEGTQHDNQSLIVKLREAEISVSKE--LGFPVTSSVMVKISPRHQFTGG 213
            :|..:..|:....:|...||...:...|..:|.|..|.:.:  |..||..::..| .|..: ||
Human   135 LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTK-GPEIR-TG- 196

  Fly   214 FSTQFRQEGKKCVELVQGQKVILTVDRQYSDRSNADVIYVNARFL--IVDVHPLDFILIGED--I 274
               ..:..|...|||.:|..:.:|:|..|.::.:.::::::.:.:  :|:|....::   :|  |
Human   197 ---LIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYV---DDGLI 255

  Fly   275 QLMVRSIHADHLKGCVARGGMLYAHMPVLFP-ARCRRFRISYEELEDLTFAREVGLNVVVSHIVG 338
            .|.|:...||.|...|..||.|.:...|..| |......:|.::::||.|..|..:::|.:..:
Human   256 SLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFI- 319

  Fly   339 TPKYVDNLEHAMSAMHCDGMRLYARVVLNEVQGCKGELNWAIKRYDGFLVELAEPATVP--DIMH 401
              :...::......:...|..:   .::::::..:|     ::|:|..| |.::...|.  |:..
Human   320 --RKASDVHEVRKVLGEKGKNI---KIISKIENHEG-----VRRFDEIL-EASDGIMVARGDLGI 373

  Fly   402 LCPDAECFMQLTY------AAKKPIIFDPRLLDEQKLRVDPAHYYYTFY---------------- 444
            ..|..:.|:....      .|.||:|...::|:....:..|.....:..
Human   374 EIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGE 438

  Fly   445 -----YPDKYV----TTCPQPKGTIYFRLLQSAIFEQISPTALANTPYCDRSHTGADSLARSVVT 500
                 ||.:.|    ....:.:..::.|.|    ||::...:..:|..       .:::|...|.
Human   439 TAKGDYPLEAVRMQHLIAREAEAAMFHRKL----FEELVRASSHSTDL-------MEAMAMGSVE 492

  Fly   501 ASIEVHAVAIVVIGVTTRMVQKISHFRPHAPILFVSHMRSAEDYVSIYHNVTMLPFRTKCIIAHR 565
            ||.:..|.|::|:..:.|...:::.:||.|||:.|:..........:|..:..:..:.....|..
Human   493 ASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWA 557

  Fly   566 RNVFLKAIYALAYLVKRKIAKQNDQVILVYNYEDGTKF 603
            .:|.|:..:|:.....|...|:.|.||::..:..|:.|
Human   558 EDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGF 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11249	NP_649346.1	Pyruvate_Kinase	158..>332	CDD:304951	44/180 (24%)
		PK_C	492..594	CDD:280960	24/101 (24%)
PKM	NP_001193725.1	Pyruvate_Kinase	116..604	CDD:238178	96/493 (19%)
		pyruv_kin	117..601	CDD:273424	96/493 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770