DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG11249 and PKLR

DIOPT Version :9

Sequence 1:NP_649346.1 Gene:CG11249 / 40409 FlyBaseID:FBgn0037115 Length:642 Species:Drosophila melanogaster
Sequence 2:NP_000289.1 Gene:PKLR / 5313 HGNCID:9020 Length:574 Species:Homo sapiens


Alignment Length:493 Identity:109/493 - (22%)
Similarity:204/493 - (41%) Gaps:72/493 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 IKHHLLGGVRCFMVNLFEGTQHDNQSLIVKLREA-EISVSKELGF-PVTSSVMVKISPRHQFTGG 213
            :|..:..|:....:|...|:...:...|..:||| |......|.: ||..::..| .|.      
Human   104 LKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTK-GPE------ 161

  Fly   214 FSTQFRQEGKKC-VELVQGQKVILTVDRQYSDRSNADVIYVNARFLIVDVHPLDFILIGED--IQ 275
            ..|...|.|.:. ||||:|.:|::|||..:..|.||:.::|:.. .||.|.|:...:..:|  |.
Human   162 IRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYP-NIVRVVPVGGRIYIDDGLIS 225

  Fly   276 LMVRSIHADHLKGCVARGGMLYAHMPVLFP-ARCRRFRISYEELEDLTFAREVGLNVVVSHIVGT 339
            |:|:.|..:.|...|..||:|.:...|..| |:.....:|.:::.||.|..|.|:::|.:..|  
Human   226 LVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFV-- 288

  Fly   340 PKYVDNLEHAMSAMHCDGMRLYARVVLNEVQGCKGELNWAIKRYDGFLVELAEPATVP--DIMHL 402
             :...::....:|:..:|   :...::::::..:|     :||:|..| |:::...|.  |:...
Human   289 -RKASDVAAVRAALGPEG---HGIKIISKIENHEG-----VKRFDEIL-EVSDGIMVARGDLGIE 343

  Fly   403 CPDAECFMQLTY------AAKKPIIFDPRLLDEQKLRVDPAHYYYTFY----------------- 444
            .|..:.|:....      .|.||::...::|:....:..|.....:..                 
Human   344 IPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGET 408

  Fly   445 ----YPDKYV----TTCPQPKGTIYFRLLQSAIFEQISPTA-LANTPYCDRSHTGADSLARSVVT 500
                :|.:.|    ....:.:..:|.|.|    ||::...| |:..|        .:..|...|.
Human   409 AKGNFPVEAVKMQHAIAREAEAAVYHRQL----FEELRRAAPLSRDP--------TEVTAIGAVE 461

  Fly   501 ASIEVHAVAIVVIGVTTRMVQKISHFRPHAPILFVSHMRSAEDYVSIYHNVTMLPFRTKCIIAHR 565
            |:.:..|.||:|:..|.|..|.:|.:||.|.::.|:....|...|.:...|..|.:|........
Human   462 AAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWA 526

  Fly   566 RNVFLKAIYALAYLVKRKIAKQNDQVILVYNYEDGTKF 603
            .:|..:..:.:.....|...:..|.||:|..:..|:.:
Human   527 DDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGY 564

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11249NP_649346.1 Pyruvate_Kinase 158..>332 CDD:304951 52/179 (29%)
PK_C 492..594 CDD:280960 25/101 (25%)
PKLRNP_000289.1 Pyruvate_Kinase 85..573 CDD:238178 109/493 (22%)
Fructose-1,6-bisphosphate binding, allosteric activator. /evidence=ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF 475..480 1/4 (25%)
Fructose-1,6-bisphosphate binding, allosteric activator. /evidence=ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF 559..564 1/4 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0469
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
32.770

Return to query results.
Submit another query.