DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11249 and pyk1

DIOPT Version :9

Sequence 1:	NP_649346.1	Gene:	CG11249 / 40409	FlyBaseID:	FBgn0037115	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_594346.1	Gene:	pyk1 / 2543557	PomBaseID:	SPAC4H3.10c	Length:	509	Species:	Schizosaccharomyces pombe

Alignment Length:	494	Identity:	93/494 - (18%)
Similarity:	192/494 - (38%)	Gaps:	111/494 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 GVRCFMVNLFEGTQHDNQSLIVKLREAEISVSKELGFPVTSSVMVKISP--RHQFTGGFSTQFRQ 220
            |:....:|...|:...:||:|...|:|  |.:..| ||:..::..| .|  |...|.| .|.:
pombe    51 GMNIVRMNFSHGSYEYHQSVIDNARKA--SATNPL-FPLAIALDTK-GPEIRTGLTVG-GTDY-- 108

  Fly   221 EGKKCVELVQGQKVILTVDRQYSDRSNADVIYVNARFLIVDVHPLDFILIGEDIQ--LMVRSIHA 283
                  .:..|.::|.|.|..|:::.|..|:|::.:.:...:.|...|.:.:.|.  .::..:..
pombe   109 ------PISSGHEMIFTTDDAYAEKCNDKVMYIDYKNITKVIQPGRIIYVDDGILSFTVIEKVDD 167

  Fly   284 DHLKGCVARGGMLYA----HMP---VLFPARCRRFRISYEELEDLTFAREVGLNVVVSHIVGTPK 341
            .:||..|...|.:.:    ::|   |..||      :|.::..||.|..:.|::::.:..:   :
pombe   168 KNLKVRVNNNGKISSKKGVNLPKTDVDLPA------LSEKDKADLRFGVKNGVDMIFASFI---R 223

  Fly   342 YVDNLEHAMSAMHCDGMRLYARVVLNEVQGCKGELNWAIKRYDGFL--------------VELAE 392
            ..:::.|....:..:|..:  :::      ||.|....:..:|..|              :|:
pombe   224 RAEDVIHIREVLGEEGKNI--KII------CKIENQQGVNNFDSILDVTDGIMVARGDLGIEI-- 278

  Fly   393 PATVPDIMHLCPDAECFMQLTYAAKKPIIFDPRLLDEQKLRVDPAHYYYTFY------------- 444
            ||:...:......|:|.:     |.||:....::|:.......|.....:..
pombe   279 PASQVFVAQKMMIAKCNI-----AGKPVACATQMLESMTYNPRPTRAEVSDVGNAVLDGADLVML 338

  Fly   445 --------YPDKYVTTCPQ---------PKGTIYFRLLQSAIFEQISPTALANTPYCDRSHTGAD 492
                    ||.:.||...:         |.|::|..:.           .|...|.    ....:
pombe   339 SGETTKGSYPVEAVTYMAETARVAEASIPYGSLYQEMF-----------GLVRRPL----ECATE 388

  Fly   493 SLARSVVTASIEVHAVAIVVIGVTTRMVQKISHFRPHAPILFVSH--MRSAEDYVSIYHNVTMLP 555
            :.|.:.:.||||..|.||||:..:....:..|.:||..||:.|:.  .|:.:.:::  ..|..:.
pombe   389 TTAVAAIGASIESDAKAIVVLSTSGNTARLCSKYRPSIPIVMVTRCPQRARQSHLN--RGVYPVI 451

  Fly   556 FRTKCIIAHRRNVFLKAIYALAYLVKRKIAKQNDQVILV 594
            :..:.:...:::|..:..|......|..|.|:.|::|::
pombe   452 YEKEPLSDWQKDVDARVAYGCQQAYKMNILKKGDKIIVL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11249	NP_649346.1	Pyruvate_Kinase	158..>332	CDD:304951	42/184 (23%)
CG11249	NP_649346.1	PK_C	492..594	CDD:280960	25/103 (24%)
pyk1	NP_594346.1	Pyruvate_Kinase	25..508	CDD:238178	93/494 (19%)
pyk1	NP_594346.1	pyruv_kin	26..505	CDD:273424	93/494 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770