DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11249 and Pklr

DIOPT Version :9

Sequence 1:	NP_649346.1	Gene:	CG11249 / 40409	FlyBaseID:	FBgn0037115	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	XP_006501198.1	Gene:	Pklr / 18770	MGIID:	97604	Length:	598	Species:	Mus musculus

Alignment Length:	499	Identity:	106/499 - (21%)
Similarity:	199/499 - (39%)	Gaps:	84/499 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 IKHHLLGGVRCFMVNLFEGTQHDNQSLIVKLRE-AEISVSKELGF-PVTSSVMVKISPRHQFTGG 213
            :|..:..|:....:|...|:...:...|..:|| ||...:..|.: ||..::..| .|.
Mouse   128 LKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFATSPLSYRPVAIALDTK-GPE------ 185

  Fly   214 FSTQFRQEGKKC-VELVQGQKVILTVDRQYSDRSNADVIYVNARFLIVDVHPL-DFILIG----- 271
            ..|...|.|.:. ||:|:|.:|::|||.::..|.:|..::       ||.|.: ..:.:|
Mouse   186 IRTGVLQGGPESEVEIVKGSQVLVTVDPKFRTRGDAKTVW-------VDYHNITQVVAVGGRIYI 243

  Fly   272 ED--IQLMVRSIHADHLKGCVARGGMLYAHMPVLFP-ARCRRFRISYEELEDLTFAREVGLNVVV 333
            :|  |.|:||.|..:.|...|..||.|.....|..| |......:|.::|.||.|..|..::::.
Mouse   244 DDGLISLVVRKIGPEGLVTEVEHGGFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIF 308

  Fly   334 SHIVGTPKYVDNLEHAMSAMHCDGMRLYARVVLNEVQGCKGELNWAIKRYDGFLVELAEPATVP- 397
            :..|   :...::.....|:..:|..:   .::::::..:|     :|::|..| |:::...|.
Mouse   309 ASFV---RKASDVVAVRDALGPEGRGI---KIISKIENHEG-----VKKFDEIL-EVSDGIMVAR 361

  Fly   398 -DIMHLCPDAECFMQLTY------AAKKPIIFDPRLLDEQKLRVDPAHYYYTFY----------- 444
             |:....|..:.|:....      .|.||::...::|:....:..|.....:..
Mouse   362 GDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCI 426

  Fly   445 ----------YPDKYV----TTCPQPKGTIYFRLLQSAIFEQISPTA-LANTPYCDRSHTGADSL 494
                      :|.:.|    ....:.:..:|.|.|    ||::...| |:..|        .:..
Mouse   427 MLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQL----FEELRRAAPLSRDP--------TEVT 479

  Fly   495 ARSVVTASIEVHAVAIVVIGVTTRMVQKISHFRPHAPILFVSHMRSAEDYVSIYHNVTMLPFRTK 559
            |...|.||.:..|.||:|:..|.|..|.:|.:||.|.::.|:....|...|.:...|..|.:|..
Mouse   480 AIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREP 544

  Fly   560 CIIAHRRNVFLKAIYALAYLVKRKIAKQNDQVILVYNYEDGTKF 603
            .......:|..:..:.:.....|...:..|.||:|..:..|:.:
Mouse   545 PEAVWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGY 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11249	NP_649346.1	Pyruvate_Kinase	158..>332	CDD:304951	50/185 (27%)
CG11249	NP_649346.1	PK_C	492..594	CDD:280960	26/101 (26%)
Pklr	XP_006501198.1	Pyruvate_Kinase	109..597	CDD:238178	106/499 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770