Protein Alignment CG11249 and pyk-2

DIOPT Version :10

• Sequence 1: NP_649346.1
• Gene: CG11249 / 40409
• FlyBaseID: FBgn0037115
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_001255515.1
• Gene: pyk-2 / 177984
• WormBaseID: WBGene00014001
• Length: 515
• Species: Caenorhabditis elegans
• Alignment Length: 510
• Identity: 103/510 - (20%)
• Similarity: 195/510 - (38%)
• Gaps: 72/510 - (14%)

  Fly   132 PNENRKC-VELTSMTNC-DLEIKHHLLG-GVRCFMVNLFEGTQHDNQSLIVKLREAEISVSKELG 193
            |.:.||. |..|....| |:|....::. |:....:|...||...:.:.|..:|||    ::...
 Worm    30 PQKTRKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREA----AENAP 90

  Fly   194 FPVTSSVMVKISPRHQFTGGFSTQFRQEGKKCVELVQGQKVILTVDRQYSDRSNADVIYVNARFL 258
            |||..::..| .|..: ||.|:...::     |:|..|:.|.::.|......:.:..||.:.|.|
 Worm    91 FPVAIALDTK-GPEIR-TGMFANNMKE-----VQLENGKSVRVSTDPSMEFAATSSHIYADYRNL 148

  Fly   259 IVDVHPLDFILIGED-IQLMVRSIHADHLKGCVARGGMLYAHMPVLFPARCRRF-RISYEELEDL 321
            ...|.|...|.|.:. |.|:|.|.....:...:..||.|.....|..|...... .::.:::|||
 Worm   149 PKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDL 213

  Fly   322 TFAREVGLNVVVSHIVGTPKYVDNLEHAMSAMHCDGMRLYARVVLNEVQGCKGELNW--AIKRYD 384
            .|..|.|::::.:..:   :..|.:......:...|..:|   ::.:::...|..|.  .|:..|
 Worm   214 LFGVEQGVDIIFASFI---RNADGIHKIRQVLGEKGKHIY---IIAKIESEDGVTNCDEIIEASD 272

  Fly   385 GFLVELAE-----PATVPDIMHLCPDAECFMQLTYAAKKPIIFDPRLLDEQKLRVDPAHYYYTFY 444
            |.:|...:     ||....:......|:|.:     |.||:|...::|:....:..|.....:..
 Worm   273 GVMVARGDLGIEIPAEKVFLAQKMLIAKCNL-----AGKPVICATQMLESMITKPRPTRAECSDV 332

  Fly   445 ---------------------YPDKYV----TTCPQPKGTIY-FRLLQSAIFEQISPTALANTPY 483
                                 ||.:.:    ..|.:.:...: .:..:..|.....||.:.:|
 Worm   333 ANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPTGMTHT-- 395

  Fly   484 CDRSHTGADSLARSVVTASIEVHAVAIVVIGVTTRMVQKISHFRPHAPILFVSHMRSAEDYVSIY 548
                      .|.:.|:|:|...||||::|..|.:..:..|.:||..||:.||........:.::
 Worm   396 ----------TAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLH 450

  Fly   549 HNVTMLPFRTKCIIAHRRNVFLKAIYALAYLVKRKIAKQNDQVILVYNYEDGTKF 603
            ..:..:.:....|.....:|..:..|.:.....|......|.:|::..::.|..|
 Worm   451 RGIFPVYYPKGRIDEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGF 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11249	NP_649346.1	Pyruvate_Kinase	158..>332	CDD:453956	44/175 (25%)
		PK_C	492..594	CDD:460738	23/101 (23%)
pyk-2	NP_001255515.1	Pyruvate_Kinase	34..514	CDD:238178	102/506 (20%)