Protein Alignment CG11249 and pyk-1

DIOPT Version :10

• Sequence 1: NP_649346.1
• Gene: CG11249 / 40409
• FlyBaseID: FBgn0037115
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_001379495.1
• Gene: pyk-1 / 172744
• WormBaseID: WBGene00009126
• Length: 913
• Species: Caenorhabditis elegans
• Alignment Length: 683
• Identity: 141/683 - (20%)
• Similarity: 247/683 - (36%)
• Gaps: 176/683 - (25%)

  Fly     3 DNEDGEERKASTFESIIDNMFSRLRIIAVDVEKLQKAKEKLNIMQRRNTFYHLLGQEEEVSMNRG 67
            ::|..|.|:.|..|...||.      |.::||:        :|.....||........:.....|
 Worm   309 NSETSESRQGSQAEDENDNS------IVIEVEE--------SISGVDCTFCSSFWNFMKCKWVLG 359

  Fly    68 SEMAILRSKYSLHSGFNQN---CSSASEEELDFEELSEDPCNISFEEDRWHGFFKDFQILTTPVG 129
            ||:|        .:|...|   .||||..    ..|:.   .::.||:....:||..|.|.....
 Worm   360 SELA--------EAGDTINEVKASSASGR----GRLAR---RMTIEEEHAGDYFKQEQKLAAVPA 409

  Fly   130 TDPNEN------RKCVELTSMTN--CDL--------EIKHHLLGGVRCFMVNLFEGTQHDNQSLI 178
            |...|:      |:...|...|.  |.:        .::..:|.|:....:|...|:...:...|
 Worm   410 TTHMEHLCRLDIREAPHLVRQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTI 474

  Fly   179 VKLREAEISVS--KELGFPV-TSSVMVKISPRHQFTGGFSTQFRQEGKKCVELVQGQKVILTVDR 240
            ..:|||..|.|  :.:|..: |....::..   ...||.|.:        :||.:|..:.||.|.
 Worm   475 ANVREAADSFSDKRVIGIALDTKGPEIRTG---LLAGGASAE--------IELARGASIRLTTDP 528

  Fly   241 QYSDRSNADVIYVNARFLIVDVHPLDFIL-IG-----ED--IQLMVRSIHADHLKGCVARGGMLY 297
            .:|:...|    ||   |.||...:..:| :|     :|  |.|:|..:..|.:...|..||||.
 Worm   529 HFSESGTA----VN---LFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLG 586

  Fly   298 AHMPVLFPARCRRF-RISYEELEDLTFAREVGLNVVVSHIVGTPKYVDNLEHAMSAMHCDGMRLY 361
            :...|..|...... .:|.::.:||.|..|.|::::.:      .::.|.|         |:|..
 Worm   587 SRKGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFA------SFIRNAE---------GIRTI 636

  Fly   362 ARV---------VLNEVQGCKG--ELNWAIKRYDGFLVELAE-----PATVPDIMHLCPDAECFM 410
            .:|         ::.:::..:|  ..:..|...||.:|...:     ||....:......::|
 Worm   637 RKVLGEKGKKIKIIAKIENQEGVDNADEIISESDGVMVARGDLGIEIPAEKVFLAQKMLISKC-- 699

  Fly   411 QLTYAAKKPIIFDPRLLDEQKLRVDPA-------------------------------------H 438
               ..|.||:|...::|:....:..|.                                     |
 Worm   700 ---NRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGETAKGEYPVDALKIMH 761

  Fly   439 YYYTFYYPDKYVTTCPQPKGTIYFRLLQSAIFEQISPTALANTPY-CDRSHTGADSLARSVVTAS 502
            |            .|.:.:..:|.|.|    |:::    |.||.. .|.|||    :|.:..:|:
 Worm   762 Y------------ICKEAEAAVYHRRL----FDEL----LQNTQKPTDMSHT----IAIAATSAA 802

  Fly   503 IEVHAVAIVVIGVTTRMVQKISHFRPHAPILFVSHMRSAEDYVSIYHNVTMLPFRTKCIIAHRRN 567
            ...||.||::|..|.|...:.|.::|..|||.:|...:....:.:|..|..:.:..:.......:
 Worm   803 ASCHASAILLITTTGRSAIQCSRYKPAVPILTISRDVAVCRQLHLYRGVFPVHYPAERAADWPTD 867

  Fly   568 VFLKAIYALAYLVKRKIAKQNDQVILVYNYEDG 600
            |..:..:|:|....|....:.|.:::|..:..|
 Worm   868 VDNRINHAIAIGKDRGFIHKGDFLVVVTGWRQG 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11249	NP_649346.1	Pyruvate_Kinase	158..>332	CDD:453956	47/185 (25%)
		PK_C	492..594	CDD:460738	22/101 (22%)
pyk-1	NP_001379495.1	Pyruvate_Kinase	429..912	CDD:238178	107/534 (20%)