Protein Alignment ORMDL and ORMDL3

DIOPT Version :10

• Sequence 1: NP_730669.1
• Gene: ORMDL / 40404
• FlyBaseID: FBgn0037110
• Length: 154
• Species: Drosophila melanogaster
• Sequence 2: NP_644809.1
• Gene: ORMDL3 / 94103
• HGNCID: 16038
• Length: 153
• Species: Homo sapiens
• Alignment Length: 152
• Identity: 76/152 - (50%)
• Similarity: 106/152 - (69%)
• Gaps: 0/152 - (0%)

  Fly     3 SIAGGHGEANPNSSWLSARGFWLAYLLGLLSVHLLFLSVPFVSIPWAWTATNLLHNAAHLYFLHV 67
            ::...|.|.|||:..:::||.||:|:|.:..:|::.||:||||:|..||.|||:||.....|||.
Human     2 NVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHIVLLSIPFVSVPVVWTLTNLIHNMGMYIFLHT 66

  Fly    68 IKGAPWLSTENDPSRRWTHWEQIDDGVQMTTTRKFLTAVPIVLFLLTCLYTRNNTEHFIPNFISL 132
            :||.|:.:.:...:|..|||||:|.|||.|.:|||||..||||:.||..||:.:..||:.|.:||
Human    67 VKGTPFETPDQGKARLLTHWEQMDYGVQFTASRKFLTITPIVLYFLTSFYTKYDQIHFVLNTVSL 131

  Fly   133 VVVTLPKLPQFHGVRLFNINKY 154
            :.|.:|||||.||||:|.||||
Human   132 MSVLIPKLPQLHGVRIFGINKY 153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORMDL	NP_730669.1	ORMDL	12..147	CDD:461151	67/134 (50%)
ORMDL3	NP_644809.1	Important for ceramide level-sensing. /evidence=ECO:0000269|PubMed:37308477	1..17		5/14 (36%)
		ORMDL	11..146	CDD:461151	67/134 (50%)