DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HAPLN4 and hapln4

DIOPT Version :9

Sequence 1:	NP_075378.1	Gene:	HAPLN4 / 404037	HGNCID:	31357	Length:	402	Species:	Homo sapiens
Sequence 2:	XP_005170516.1	Gene:	hapln4 / 559818	ZFINID:	ZDB-GENE-060503-243	Length:	419	Species:	Danio rerio

Alignment Length:	340	Identity:	215/340 - (63%)
Similarity:	262/340 - (77%)	Gaps:	10/340 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    26 PAGAQRGRKKVVHVLEGESGSVVVQTAPGQVVSHRGGTIVLPCRYHYEAAAHGHDGVRLKWTKVV 90
            ||..::||::||||:|.::|:|:||||||:||:||||||.||||||:|......:.:|:|||||.
Zfish    65 PADLEKGRRRVVHVMEDDTGAVIVQTAPGKVVTHRGGTITLPCRYHHEPEDIDPNRIRIKWTKVS 129

Human    91 DPLAFTDVFVALGPQHRAFGSYRGRAELQGDGPGDASLVLRNVTLQDYGRYECEVTNELEDDAGM 155
            |...|.|||||||.|.:|||||:.|..|:..||||||:::.|:||:|||||||||||::|||.|.
Zfish   130 DAFQFEDVFVALGRQQKAFGSYQERVSLEQAGPGDASVIIHNITLEDYGRYECEVTNDMEDDTGF 194

Human   156 VKLDLEGVVFPYHPRGGRYKLTFAEAQRACAEQDGILASAEQLHAAWRDGLDWCNAGWLRDGSVQ 220
            |.||||||||||:|..|||||.:.:|:..|.|||.||||..|||.||.:||||||||||.|||||
Zfish   195 VNLDLEGVVFPYYPPSGRYKLNYHQAEEVCREQDAILASHPQLHKAWLEGLDWCNAGWLEDGSVQ 259

Human   221 YPVNRPREPCGGLGGTGSAGGGGDANGGLRNYGYRHNAEERYDAFCFTSNLPGRVFFLKPLRPVP 285
            ||::.||:.|          |..|:..|:|||||||..:||||||||||||.|||:|||..:.|.
Zfish   260 YPISHPRDQC----------GRKDSPPGVRNYGYRHKDDERYDAFCFTSNLNGRVYFLKRFKKVN 314

Human   286 FSGAARACAARGAAVAKVGQLFAAWKLQLLDRCTAGWLADGSARYPIVNPRARCGGRRPGVRSLG 350
            :..|.:||...||.:||||||:||||:||||||.|||:.|||.|||||||||||||..||||:||
Zfish   315 YLEAVKACQRDGAFIAKVGQLYAAWKIQLLDRCEAGWVEDGSIRYPIVNPRARCGGPDPGVRNLG 379

Human   351 FPDATRRLFGVYCYR 365
            |||...||:||||:|
Zfish   380 FPDKKFRLYGVYCFR 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HAPLN4	NP_075378.1	Ig	60..164	CDD:325142	65/103 (63%)
		Link_Domain	163..267	CDD:322016	61/103 (59%)
		Link_Domain	274..364	CDD:322016	60/89 (67%)
hapln4	XP_005170516.1	IG_like	92..197	CDD:214653	65/104 (63%)
		Ig_LP_like	99..203	CDD:143285	65/103 (63%)
		Link_Domain	202..296	CDD:295393	61/103 (59%)
		Link_domain_HAPLN_module_2	303..393	CDD:239596	60/89 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194337634
Domainoid	1	1.000	136	1.000	Domainoid score	I19909
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11304
Inparanoid	1	1.050	445	1.000	Inparanoid score	I7256
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG38955
OrthoDB	1	1.010	-	-		D244936at7742
OrthoFinder	1	1.000	-	-		FOG0011537
OrthoInspector	1	1.000	-	-		oto45187
orthoMCL	1	0.900	-	-		OOG6_116040
Panther	1	1.100	-	-	LDO	PTHR22804
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10216
SonicParanoid	1	1.000	-	-		X9215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.440