DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED1 and med1

DIOPT Version :9

Sequence 1:	NP_649341.1	Gene:	MED1 / 40403	FlyBaseID:	FBgn0037109	Length:	1475	Species:	Drosophila melanogaster
Sequence 2:	NP_001090727.1	Gene:	med1 / 100036710	-ID:	-	Length:	1573	Species:	Xenopus tropicalis

Alignment Length:	1685	Identity:	403/1685 - (23%)
Similarity:	621/1685 - (36%)	Gaps:	461/1685 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 TMMEKLRAKY-RNKPKSYEEIKKSVRMYFIEKHYPLDPLCKATLQSALDKLQHYIKVTSRHGLVE 94
            :::|:|.:|| :|:|  :.|..|.||. .:||...:.......|.|.|:.||..:||:|...:.:
Frog     3 SLLERLHSKYSQNRP--WPETIKLVRQ-IMEKRTGMMSGSHQHLVSCLETLQKALKVSSLSAMTD 64

  Fly    95 RLESLSRQLGL--KFMEDQQLLFISTDMFYVEILLDAAGSLSDVKVHHECKIEQQSSELVACLKS 157
            ||||::||.||  ....:....:|:|||||:|:|||..|.|.||||.|..:......|||..|:.
Frog    65 RLESIARQNGLTSHLSPNGTECYITTDMFYLEVLLDTEGQLCDVKVAHHRENPVSCPELVEQLRE 129

  Fly   158 GDFADFTVQLEGLSSIYQLNAEPKVKKKAFVALQAMETDIQSLYQLHLQGHSGDSYSLMTSSSVG 222
            .:|.||:..|:||.::|::..:.|::.|.::|||::|.|:..:..::.|..:......:...:||
Frog   130 KNFEDFSQHLKGLVNLYKVPGDNKLETKMYLALQSLELDLTKMAAMYWQATNASVLEKILHGTVG 194

  Fly   223 LVLPRRGGHPMRLTYFCPPLHLPEGDPKLASGDFTIDQVMRSSYGLSATINLEGSSANKLQTLPT 287
            .:.||.||..|.|.|:..|..|.: |...||...:....:..|.|::.::.:|.:||  :..||.
Frog   195 YLTPRSGGQVMSLKYYVSPYDLFD-DTTGASISLSEGHAVPRSLGMNVSVTIEATSA--MYKLPI 256

  Fly   288 VTLVRDAQ--TGLEVPTYAQLNQNNSLLMPATFVLRLNKPMPVCLESLKAL----GLPGLDSVAT 346
            ..|:..:.  .....|::..:...||:.:||.|.|:..:|:||....::.:    |:|.:|...|
Frog   257 APLIMGSHPIDNKGTPSFTSITNANSVDLPACFFLKFPQPIPVSRAFIQKIQHCTGIPLIDGSHT 321

  Fly   347 --PPGPPTTVLNLIVQTASKQAIKNTQRGLYVNLPKETHCYF------FTDNRKLQGTLVSSLPF 403
              |.....|...|..:  .:....|.....|.:||.:.||||      ..|.|.|||||:|.:||
Frog   322 FLPHYELVTQFELAKE--KEPGTLNHNMRFYASLPGQQHCYFVNKDAPLPDGRSLQGTLLSKIPF 384

  Fly   404 TEPAQVPRIVAFLKKQALFYTLLASCVREQQKQYNDMDSTVILEVTAVSFNQITVELQHPYEESL 468
            ..|.:||.|::.::.|....||:.|||:....: .|....:..||..:|.:..::..|||..:||
Frog   385 QHPGRVPIILSLIRHQVACNTLIGSCVKRTMLK-EDCPGLLQFEVAPLSDSCFSISFQHPVNDSL 448

  Fly   469 ATVDFLLED-GQPTCSVY--------CLTNEYELLSQKLTRTARKVVSIPMVIYKL--------- 515
            ..|...::| ...:|.:|        | |:::      :|:..::.:|||:.:..:
Frog   449 VCVVMDVQDSSHVSCKLYKGLSDALIC-TDDF------ITKVVQRCMSIPVTMRAIRRKAETIQA 506

  Fly   516 ----LKCWDEEHEFKLHGAIGPGSGSG---AIGGGGMSG---------GGPVS------------ 552
                |....|..|..:...:.|.|..|   |.|...:||         .|.:|
Frog   507 DTPALSLIAETVEDMVKKNLPPASSPGYGMASGSTALSGITTPTSSYTSGQISSLFNMGIKERHD 571

  Fly   553 --GVGNNFSQF---------------------SMDTP---TPSDGSLPGGGFAN---INNLKMDA 588
              |.|::||:.                     |..||   ||...|.|.....|   :.||..|.
Frog   572 SAGHGDDFSKVTQNPILTSLLQITSNSGGTLGSSPTPPQHTPPPASSPASNTKNHPMLMNLLKDN 636

  Fly   589 KSRSLADAFAASTSAAAAIAGLINLKRETDPQSGSSASGTTVSGSSSSSGSAKTSDHDIADKYKN 653
            .::..:..:..|.           |:|:     .||.|..|..|||:|....|.......:|.||
Frog   637 PAQDFSTLYGGSP-----------LERQ-----NSSGSPRTELGSSASGKPKKKRPRTGTEKMKN 685

  Fly   654 IWKD---------------------------KTPNLKHCVSITPIPGDGKSGSAGGV-------S 684
            ..:|                           .||:      |||.|  .:.|:...|       :
Frog   686 QTEDDFQRELFSMDVDSQNTIFDVGMAGDALDTPH------ITPAP--SQCGTPPNVYQQAIPHT 742

  Fly   685 GVEVQRTGGI----EIIP---------LNAQAAIAGGGVTASSSATPTTITITPITGKDPSKDST 736
            ...:||...|    .|||         ....:.:.|.|....:..||.         :|.|....
Frog   743 QANMQRMVRIPSTDAIIPDVTDILSDIAEEASKLPGPGEDCPNLGTPV---------RDSSSSGH 798

  Fly   737 KKST-------AASAGVGVAAKRP-----------HESSTSSSST---SGCSGSGSSMSSSASSG 780
            .:||       ....|.|...:.|           |.|..|.|..   :....:...::|.:.||
Frog   799 SQSTLFDTDVFQVDGGGGSGGENPYPDPVDLIVDSHGSPNSDSPNTFFNSVDFNPDLLNSQSQSG 863

  Fly   781 SSDTQKEKKRKKKRDD----------------------------------------------SPM 799
            .:|...:...:...:|                                              ..:
Frog   864 FTDDLNDDSSQSGDNDFKDFAGPGLASLGIVSGLPVDGGDGKYKMALGADTVDFSIIAGGGSKNL 928

  Fly   800 GPP--EKIYSRQNSPAGGADASATGGVVRKFSSPSSSPKAGGGGQGL----MAGVPTAR---PS- 854
            |.|  ::..||..||..|:|........:|.....:...||||..|:    |.|....|   ||
Frog   929 GGPDIQETQSRSQSPLLGSDLGKDRPQKQKVKESGNGGGAGGGLSGMQSAGMEGKSMKRSRTPSS 993

  Fly   855 --------PKHSPVYS---SPKH--NTASNSPKSPFGTHSPKHGSSGK----PSMSTLKSAATAA 902
                    ||.....|   ||.|  |.....|.|..|:.||  |:||:    |.|:|  ......
Frog   994 DGKSKDKPPKRKKTESDGKSPSHITNRPFTPPTSTGGSKSP--GTSGRSQTPPGMAT--PPIPKI 1054

  Fly   903 TILSPKG----DKSSSAVGNTSSGPSASSGSSGATGLVRSFASVGAPPPPPPIPPLASSSGSISS 963
            ||..|||    .|.||....:|||.|:||.|....|                     .||.|.|:
Frog  1055 TIQIPKGTMSVGKPSSHSQYSSSGSSSSSSSKSHHG---------------------HSSLSSSA 1098

  Fly   964 SQSLKKEKTSSASGSSSTSSSATAGVASGGGISPASVAAAVAALKSSQQQMKSVASLSHLAAGGG 1028
            |..:|..|:..:||....|        ||||:.......:.:..|:|.|.|
Frog  1099 SGKIKSNKSDGSSGMKIGS--------SGGGMYSGQSGQSNSQSKNSSQSM-------------- 1141

  Fly  1029 LGSYAAPSGAGASGAAAVVVGAGAGAGAGASGLELSALRKGMAGGAVSLMTSTAALAPTIPAPTT 1093
                      |.:|::.:.      ....:|.:..|:..|....|..|::.:.:...|.| :|:.
Frog  1142 ----------GKAGSSPIT------KHGLSSNVNNSSGSKTKPQGKPSVLMNPSLSKPNI-SPSH 1189

  Fly  1094 TVAAGSAASLVSPVSAVVGQGQETAGAAAAATLATATILQQQPQPGAAPTSSCLTT--SGGSSDS 1156
            :..:|.:..|.||:                           :|.||..|:|...:.  |||...|
Frog  1190 SRPSGGSDKLSSPM---------------------------KPMPGTPPSSKAKSPIGSGGQHLS 1227

  Fly  1157 AGSINPAGASTEYMVKPSSQEGLKLTINKTGSSKSSGTGSGSSSSSGLQAKAKSSSSGATSFAGS 1221
            ....|....|:..:|...|     || .|..||.||.:.|.||||        ||||.::||  |
Frog  1228 GSGSNSTTKSSSGLVSSGS-----LT-QKPNSSSSSSSSSSSSSS--------SSSSSSSSF--S 1276

  Fly  1222 TGSTKKQHT---GLKPGVNSGPASKKATAAVSSATASSSKHFFQKANSSGNLSSKLSGSGSGGGI 1283
            :|.::..|:   |..|..|..|:   .||.:...     ||   ...:.|..|......|.|||.
Frog  1277 SGVSQNLHSSSKGKSPSRNKKPS---LTAVIDKL-----KH---GVGTGGPGSEDPMDGGVGGGS 1330

  Fly  1284 PLTKSNSTNSFQEHN------APRRRPSMGALASGSSGGGSGQRKLGSASGGGSGSSGSVSPALS 1342
            ....|:..:|  :|.      ..:|.......:.|||||.|...|.|.....||.|:|.....:|
Frog  1331 TGAPSHGMSS--KHGLGVGEFPTKREKGEKDKSKGSSGGPSDPSKKGGGDSKGSVSTGVAKIIIS 1393

  Fly  1343 GSMSQPPPRFDHHTDMMTILQYASPTMAASM-----EGFIKGLHNKFQIPKLSQRGSGGNTTSGR 1402
                       .|..       .||::.|.:     ||..:||.::.|....|...||......|
Frog  1394 -----------KHDG-------GSPSIKAKVTLQKPEGGGEGLRSQMQKNYGSPLISGSTPKHER 1440

  Fly  1403 STPSGSSEPALAGTSSSILGPIASSTGLTEPEAKPPVPPSQSGNEGLLNLSSTAGTPSAD 1462
            .:||.:..||..                  |:|..  ..|:||:..:.. .|...:||:|
Frog  1441 CSPSHNKSPAYT------------------PQALD--SESESGSSSIAE-KSYQNSPSSD 1479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED1	NP_649341.1	Med1	75..431	CDD:287688	117/371 (32%)
med1	NP_001090727.1	Med1	45..412	CDD:287688	117/371 (32%)
		LXXLL motif 1	588..592		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	595..691		27/111 (24%)
		LXXLL motif 2	629..633		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	774..883		20/117 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	928..1564		176/711 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	182	1.000	Domainoid score	I3394
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2770
OMA	1	1.010	-	-		QHG47792
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005568
OrthoInspector	1	1.000	-	-		otm48012
Panther	1	1.100	-	-	LDO	PTHR12881
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4643
SonicParanoid	1	1.000	-	-		X5411
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190