DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alg11 and ALG11

DIOPT Version :9

Sequence 1:	NP_001262182.1	Gene:	Alg11 / 40402	FlyBaseID:	FBgn0037108	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_014350.1	Gene:	ALG11 / 855679	SGDID:	S000004993	Length:	548	Species:	Saccharomyces cerevisiae

Alignment Length:	540	Identity:	181/540 - (33%)
Similarity:	281/540 - (52%)	Gaps:	105/540 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FLFLLWLLLSLVLV----AVLSFLFLRQWLLGRKNKLHTSS-----------ENGINV-GIFHPY 52
            |.|..:::.|||||    .||:::| |||:....|.....|           |..:.| |.||||
Yeast    17 FGFKKYVVSSLVLVYGLIKVLTWIF-RQWVYSSLNPFSKKSSLLNRAVASCGEKNVKVFGFFHPY 80

  Fly    53 CNAGGGGERVLWCAVRALQEKYQNARMVIYTGDI----DASPNSILQKAKNVFNIAVDSDNVKFV 113
            ||||||||:|||.||.....|.....:|||:||.    :.:|.:||...|..|:..:|||.:.|:
Yeast    81 CNAGGGGEKVLWKAVDITLRKDAKNVIVIYSGDFVNGENVTPENILNNVKAKFDYDLDSDRIFFI 145

  Fly   114 FLKQRHWIEAKNYPHFTLLGQSIGSMVVGLEALCRFPPDIYIDTMGYAFTYPLF-RYLAQSKVGC 177
            .||.|:.:::..:.||||:||:||||::..|::.:.||||:||||||.|:||:. |:|.:..:..
Yeast   146 SLKLRYLVDSSTWKHFTLIGQAIGSMILAFESIIQCPPDIWIDTMGYPFSYPIIARFLRRIPIVT 210

  Fly   178 YVHYPVISTDMLKRVQQRQMSHNNKKY-VARNPFLTWTKLAYYRLFSRMYKWVGCCAETIMVNSS 241
            |.|||::|.|||           ||.: :.:.....:.|:.|:::|..:|:.:|...:.::.||:
Yeast   211 YTHYPIMSKDML-----------NKLFKMPKKGIKVYGKILYWKVFMLIYQSIGSKIDIVITNST 264

  Fly   242 WTENHILQLWDVPFKTHR-VYPPCEVSHL---KSLQHTEKGD---EFIILSVGQFRPEKDHPLQL 299
            ||.|||.|:|.  ..|.: :||||....|   |....|.||:   :.|:|:  ||||||.|.|.:
Yeast   265 WTNNHIKQIWQ--SNTCKIIYPPCSTEKLVDWKQKFGTAKGERLNQAIVLA--QFRPEKRHKLII 325

  Fly   300 QAIYELRTLLAQDEALWNQIKLVIVGSCRNEDDYERLKNMQD-------LTKHLSLENNVQFSVN 357
            ::   ..|.|.......:.|||::.||.|::.|...:|::||       :.|||     :.|..|
Yeast   326 ES---FATFLKNLPDSVSPIKLIMAGSTRSKQDENYVKSLQDWSENVLKIPKHL-----ISFEKN 382

  Fly   358 VPYEDLLKLYQTAHIGIHTMWNEHFGIGIVESMAAGLIMVAHKSGGPLLDIVE------------ 410
            :|::.:..|...:..|::.||||||||.:||.||:|||.:.|.|.|||||||.
Yeast   383 LPFDKIEILLNKSTFGVNAMWNEHFGIAVVEYMASGLIPIVHASAGPLLDIVTPWDANGNIGKAP 447

  Fly   411 -------------TSAGSQNGFL-----------ATDAVEYAENILNIIVNNSEMN-------GI 444
                         ...|...||.           ..|.:.| .|:.::.:..::::       |.
Yeast   448 PQWELQKKYFAKLEDDGETTGFFFKEPSDPDYNTTKDPLRY-PNLSDLFLQITKLDYDCLRVMGA 511

  Fly   445 RNAARASVERFSEQEFEKNF 464
            || .:.|:.:||:.:|:|::
Yeast   512 RN-QQYSLYKFSDLKFDKDW 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg11	NP_001262182.1	PLN02949	24..473	CDD:215511	172/516 (33%)
Alg11	NP_001262182.1	GT1_ALG11_like	44..463	CDD:99978	164/482 (34%)
ALG11	NP_014350.1	GT4_ALG11-like	72..529	CDD:340835	164/481 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346826
Domainoid	1	1.000	177	1.000	Domainoid score	I728
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68893
Inparanoid	1	1.050	272	1.000	Inparanoid score	I595
Isobase	1	0.950	-	0	Normalized mean entropy	S1546
OMA	1	1.010	-	-		QHG53627
OrthoFinder	1	1.000	-	-		FOG0004723
OrthoInspector	1	1.000	-	-		oto99335
orthoMCL	1	0.900	-	-		OOG6_101910
Panther	1	1.100	-	-	LDO	PTHR45919
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R38
SonicParanoid	1	1.000	-	-		X3321
TreeFam	1	0.960	-	-
	16	15.740