DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alg11 and alg11

DIOPT Version :9

Sequence 1:	NP_001262182.1	Gene:	Alg11 / 40402	FlyBaseID:	FBgn0037108	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_001154823.1	Gene:	alg11 / 407614	ZFINID:	ZDB-GENE-030131-7282	Length:	500	Species:	Danio rerio

Alignment Length:	486	Identity:	238/486 - (48%)
Similarity:	308/486 - (63%)	Gaps:	25/486 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLWLL------LSLVLVAVLSFLFL---RQWLLGRKNKLHTSSENGINVGIFHPYCNAGGGGERV 62
            |||.|      ||.:|..:| |||:   |.| |..|.|.....:....|..||||||||||||||
Zfish    17 LLWSLMLPCFYLSFLLTTIL-FLFIMGVRSW-LQMKRKTRRVQDGRPAVAFFHPYCNAGGGGERV 79

  Fly    63 LWCAVRALQEKYQNARMVIYTGDIDASPNSILQKAKNVFNIAVDSDNVKFVFLKQRHWIEAKNYP 127
            ||||:||||.:||:...|:||||...:...||..|:..|||.:... |||||||.|..:|||.||
Zfish    80 LWCALRALQNRYQDVSFVVYTGDQGVTAEEILDGARRRFNIRLPRP-VKFVFLKHRLLVEAKLYP 143

  Fly   128 HFTLLGQSIGSMVVGLEALCRFPPDIYIDTMGYAFTYPLFRYLAQSKVGCYVHYPVISTDMLKRV 192
            ||||||||:||:.:|.|||..|.||:|||:||:|||.|:||||...:||.|||||.||||||..|
Zfish   144 HFTLLGQSVGSIFLGWEALTEFVPDLYIDSMGFAFTLPVFRYLGGCQVGSYVHYPTISTDMLSVV 208

  Fly   193 QQRQMSHNNKKYVARNPFLTWTKLAYYRLFSRMYKWVGCCAETIMVNSSWTENHILQLWDVPFKT 257
            ::|....||..|::.||.|:..|:.||.:|:.:|...|.|::.|||||:||..|||.||..|.:|
Zfish   209 RERNPRFNNADYISSNPVLSAIKVIYYCVFALLYGLAGSCSDVIMVNSTWTLGHILALWRTPNRT 273

  Fly   258 HRVYPPCEVSHLKSLQHTEKGDE------FIILSVGQFRPEKDHPLQLQAIYELRTLLAQDEALW 316
            ..|||||:|.....:...|..:|      ..::|||||||||||.||::|..:|......:.|..
Zfish   274 SVVYPPCDVQAFLDVPIGEDNEEKEQKKCHSLVSVGQFRPEKDHQLQIRAFKKLLDRKEVEPAGR 338

  Fly   317 NQIKLVIVGSCRNEDDYERLKNMQDLTKHLSLENNVQFSVNVPYEDLLKLYQTAHIGIHTMWNEH 381
            ..:|||::|.|||::|.:|:..::.|.:.|.:.:.|:|.:|:|:::|.|....|.||:|||||||
Zfish   339 EAVKLVLIGGCRNQEDEDRVLMLRGLCQELGIADRVEFKLNIPFQELKKDLTDATIGLHTMWNEH 403

  Fly   382 FGIGIVESMAAGLIMVAHKSGGPLLDIVETSAGSQNGFLATDAVEYAENILNII----VNNSEMN 442
            |||||||.||||.|::|||||||.||||....|...||||.|...||:.:..|:    ....||
Zfish   404 FGIGIVECMAAGTIILAHKSGGPKLDIVVPYDGGPTGFLADDEDNYADAMERILSMSPATRLEM- 467

  Fly   443 GIRNAARASVERFSEQEFEKNFLRAVSTLFT 473
              |..||.||.|||:||||.:||.|:..|.:
Zfish   468 --RRRARLSVSRFSDQEFEGSFLSAMEPLMS 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg11	NP_001262182.1	PLN02949	24..473	CDD:215511	228/461 (49%)
Alg11	NP_001262182.1	GT1_ALG11_like	44..463	CDD:99978	218/428 (51%)
alg11	NP_001154823.1	PLN02949	26..496	CDD:215511	234/475 (49%)
alg11	NP_001154823.1	GT1_ALG11_like	63..486	CDD:99978	218/426 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596895
Domainoid	1	1.000	248	1.000	Domainoid score	I2108
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68893
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1642
OMA	1	1.010	-	-		QHG53627
OrthoDB	1	1.010	-	-		D1051021at2759
OrthoFinder	1	1.000	-	-		FOG0004723
OrthoInspector	1	1.000	-	-		oto39012
orthoMCL	1	0.900	-	-		OOG6_101910
Panther	1	1.100	-	-	LDO	PTHR45919
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R38
SonicParanoid	1	1.000	-	-		X3321
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800