DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alg11 and Alg2

DIOPT Version :9

Sequence 1:	NP_001262182.1	Gene:	Alg11 / 40402	FlyBaseID:	FBgn0037108	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_001094180.1	Gene:	Alg2 / 313231	RGDID:	1309940	Length:	415	Species:	Rattus norvegicus

Alignment Length:	463	Identity:	118/463 - (25%)
Similarity:	189/463 - (40%)	Gaps:	100/463 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 NVGIFHPYCNAG-GGGERVLWCAVRALQEKYQNARMVIYTGDIDASPNSILQKAKNVFNIAVDSD 108
            :|...||  :.| ||.||::..|..||||  ...::.|:|...|  ||....:.:.: ::....|
  Rat    16 SVLFLHP--DMGIGGAERLVLDAALALQE--YGCQVKIWTAHYD--PNHCFIETREL-SVQCAGD 73

  Fly   109 -----------------NVKFVFLKQRHWIEAKNYPHFTLLGQSIGSMVVGLEALCRFPPDIYID 156
                             .|:.|||..        |..| |.|:....:|....:.|
  Rat    74 WLPRSLGWGGRGAAICSYVRMVFLAL--------YVLF-LSGEEFDVVVCDQVSAC--------- 120

  Fly   157 TMGYAFTYPLFRYLAQSK-VGCYVHYPVISTDMLKRVQQRQMSHNNKKYVARNPFLTWTKLAYYR 220
                   .|:|:...:.| |..|.|:|    |:|  :.||..|  .||:. |.| :.|.:
  Rat   121 -------IPVFKLARRRKRVLFYCHFP----DLL--LTQRNSS--LKKFY-RAP-IDWIE----- 163

  Fly   221 LFSRMYKWVGCCAETIMVNSSWTENHILQLWDVPFKT--HR----VYPPCEVSHL------KSLQ 273
                  ::....|:.|:|||.:|.:    ::...|||  ||    :||...:...      |...
  Rat   164 ------EYTTGMADRILVNSQYTAS----VFKETFKTLSHRNPDVLYPSLNIGSFDLAVPEKIDD 218

  Fly   274 HTEKGDEFIILSVGQFRPEKDHPLQLQAIYELRTLLAQDEALWNQIKLVIVGSC--RNEDDYERL 336
            ...||.:|:.||:.::..:|:.||.|.::.:||..|...|  |.::.|.:.|..  |..::.|..
  Rat   219 LVPKGKQFLFLSINRYERKKNLPLALSSLVQLRARLPPQE--WEKVHLFMAGGYDDRVLENVEHY 281

  Fly   337 KNMQDLTKHLSLENNVQFSVNVPYEDLLKLYQTAHIGIHTMWNEHFGIGIVESMAAGLIMVAHKS 401
            |.::.:.:...||.:|.|..:......:.|.......::|..||||||..:|:|.....::|..|
  Rat   282 KELKKIVQESDLERHVTFLRSFSDRQKISLLHGCLCVLYTPSNEHFGIVPLEAMYMQCPVIAVNS 346

  Fly   402 GGPLLDIVETSAGSQNGFLA-TDAVEYAENILNIIVNNS--EMNGIRNAARASVERFSEQEFEKN 463
            ||||..||.    ...|||. .|.|.::|.:...|...|  ...|:...||.: |:||...|...
  Rat   347 GGPLESIVH----KVTGFLCEPDPVHFSEAMEKFIHKPSLKATMGLAGKARVA-EKFSADAFADQ 406

  Fly   464 FLRAVSTL 471
            ..:.|:.|
  Rat   407 LYQYVTKL 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg11	NP_001262182.1	PLN02949	24..473	CDD:215511	118/463 (25%)
Alg11	NP_001262182.1	GT1_ALG11_like	44..463	CDD:99978	116/453 (26%)
Alg2	NP_001094180.1	GT4_ALG2-like	17..407	CDD:340834	116/453 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810