DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alg11 and Alg11

DIOPT Version :9

Sequence 1:	NP_001262182.1	Gene:	Alg11 / 40402	FlyBaseID:	FBgn0037108	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_001230090.1	Gene:	Alg11 / 207958	MGIID:	2142632	Length:	492	Species:	Mus musculus

Alignment Length:	479	Identity:	233/479 - (48%)
Similarity:	320/479 - (66%)	Gaps:	10/479 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLFLFLLWLLLSLVLVAVLSF-LFLRQWLLGRKNKLHTSSENGIN---VGIFHPYCNAGGGGERV 62
            |..||...|::..||...|.. |::.:|.|.||.|..::|:||..   |..||||||||||||||
Mouse    17 FYSLFFPGLMICGVLCVYLVIGLWVIRWHLQRKKKSVSTSKNGKEQTVVAFFHPYCNAGGGGERV 81

  Fly    63 LWCAVRALQEKYQNARMVIYTGDIDASPNSILQKAKNVFNIAVDSDNVKFVFLKQRHWIEAKNYP 127
            ||||:||||:||..|..|:|||||:.|...||..|...|||.: :..|:||||::|:.:|...||
Mouse    82 LWCALRALQKKYPEAVYVVYTGDINVSGQQILDGAFRRFNIKL-AHPVQFVFLRKRYLVEDSRYP 145

  Fly   128 HFTLLGQSIGSMVVGLEALCRFPPDIYIDTMGYAFTYPLFRYLAQSKVGCYVHYPVISTDMLKRV 192
            ||||||||:||:::|.|||.:..||:|||:||||||.|||:|:...:||.|||||.||||||..|
Mouse   146 HFTLLGQSLGSILLGWEALMQRVPDVYIDSMGYAFTLPLFKYVGGCRVGSYVHYPTISTDMLSVV 210

  Fly   193 QQRQMSHNNKKYVARNPFLTWTKLAYYRLFSRMYKWVGCCAETIMVNSSWTENHILQLWDVPFKT 257
            :.:....||..:::||..|:..||.||.||:.:|..||.|::.:|||||||.||||.||.|...|
Mouse   211 KNQNPGFNNAAFISRNALLSKAKLIYYYLFAFVYGLVGSCSDIVMVNSSWTLNHILSLWKVGHCT 275

  Fly   258 HRVYPPCEVSHLKSLQHTEK--GDEFIILSVGQFRPEKDHPLQLQAIYELRTLLAQDEALWNQIK 320
            :.|||||:|.....:...||  ....:::|:|||||||:|.||::|..:|....|.:  |.:.:|
Mouse   276 NIVYPPCDVQTFLDIPLHEKKVTPGHLLVSIGQFRPEKNHALQIKAFAKLLNEKAAE--LGHSLK 338

  Fly   321 LVIVGSCRNEDDYERLKNMQDLTKHLSLENNVQFSVNVPYEDLLKLYQTAHIGIHTMWNEHFGIG 385
            ||::|.|||:||..|:..::.|:::|.::.||:|.:|:.:::|......|.||:|||||||||||
Mouse   339 LVLIGGCRNKDDEFRVNQLRSLSENLGVQENVEFKINISFDELKNYLSEATIGLHTMWNEHFGIG 403

  Fly   386 IVESMAAGLIMVAHKSGGPLLDIVETSAGSQNGFLATDAVEYAENILNII-VNNSEMNGIRNAAR 449
            :||.||||.:::||.||||.||||....|...||||.....||:::.:|: ::..|...||..||
Mouse   404 VVECMAAGTVILAHNSGGPKLDIVIPHEGQITGFLAESEEGYADSMAHILSLSAEERLQIRKNAR 468

  Fly   450 ASVERFSEQEFEKNFLRAVSTLFT 473
            ||:.|||:||||..||.::..|.|
Mouse   469 ASISRFSDQEFEVAFLCSMEKLLT 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg11	NP_001262182.1	PLN02949	24..473	CDD:215511	224/454 (49%)
Alg11	NP_001262182.1	GT1_ALG11_like	44..463	CDD:99978	213/424 (50%)
Alg11	NP_001230090.1	PLN02949	64..492	CDD:215511	216/428 (50%)
Alg11	NP_001230090.1	GT1_ALG11_like	64..480	CDD:99978	212/418 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850851
Domainoid	1	1.000	248	1.000	Domainoid score	I2145
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68893
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1647
Isobase	1	0.950	-	0	Normalized mean entropy	S1546
OMA	1	1.010	-	-		QHG53627
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004723
OrthoInspector	1	1.000	-	-		oto92871
orthoMCL	1	0.900	-	-		OOG6_101910
Panther	1	1.100	-	-	LDO	PTHR45919
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R38
SonicParanoid	1	1.000	-	-		X3321
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740