DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alg11 and algn-11

DIOPT Version :9

Sequence 1:	NP_001262182.1	Gene:	Alg11 / 40402	FlyBaseID:	FBgn0037108	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_498606.1	Gene:	algn-11 / 176032	WormBaseID:	WBGene00015162	Length:	470	Species:	Caenorhabditis elegans

Alignment Length:	470	Identity:	191/470 - (40%)
Similarity:	282/470 - (60%)	Gaps:	28/470 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LWLLLSLVLVAVLSFLFLRQWLLGRKNKLHTSSENGINVGIFHPYCNAGGGGERVLWCAVRALQE 72
            ::.|:.|::..::.|.....:  .||:|         .|..||||||||||||||||.|:|.:|:
Worm    16 VFYLVPLIIALIIPFSLYSGF--RRKSK---------TVAFFHPYCNAGGGGERVLWAAIRTMQK 69

  Fly    73 KYQNARMVIYTGDIDASPNSILQKAKNVFNIAVDSDNVKFVFLKQRHWIEAKNYPHFTLLGQSIG 137
            |:.:.:..:|:||.||:...||.||:..|.|.:|..|::|::|..|..:||::|.|.|:|.|::.
Worm    70 KFPDHKYFVYSGDTDATKEQILLKARQRFGIELDPSNIQFIYLHWRTLVEARHYKHCTMLFQALA 134

  Fly   138 SMVVGLEALCRFPPDIYIDTMGYAFTYPLFRYLAQSKVGCYVHYPVISTDMLKRVQQRQMSHNNK 202
            .:::.|||..|..|.::||:|||..:.|.|| |:.|||..|||||.||.|||..|:.||.:.||.
Worm   135 GLILALEAWFRMVPAVFIDSMGYPLSLPAFR-LSGSKVVAYVHYPTISCDMLDVVESRQETFNNS 198

  Fly   203 KYVARNPFLTWTKLAYYRLFSRMYKWVGCCAETIMVNSSWTENHILQLW---DVPFKTHRVYPPC 264
            ..:|::..|:|.||.|||||:.:|...|..|...|||.|||:.||..:|   ||..    |||||
Worm   199 STIAQSNVLSWGKLTYYRLFACLYWLAGKAAHVGMVNGSWTQRHITSIWSRRDVSI----VYPPC 259

  Fly   265 EVSHLKSLQHT-----EKGDEFIILSVGQFRPEKDHPLQLQAIYELRTLLAQDEALWNQIKLVIV 324
            :|....:::..     |......:|||||.||||:|.|||:.:::::..|   |.:...::|.|.
Worm   260 DVEAFLNIESVAESLLEDTKTVRLLSVGQIRPEKNHKLQLEVLHDVKEPL---EKMGYNVELCIA 321

  Fly   325 GSCRNEDDYERLKNMQDLTKHLSLENNVQFSVNVPYEDLLKLYQTAHIGIHTMWNEHFGIGIVES 389
            |.||||:|.||:|.:::..:.|.:...:.:.:|||||||:.....|.|.||||.||||||.:||:
Worm   322 GGCRNEEDQERVKMLKNEAEKLDISEQLIWQLNVPYEDLVVELSKALISIHTMHNEHFGISVVEA 386

  Fly   390 MAAGLIMVAHKSGGPLLDIVETSAGSQNGFLATDAVEYAENILNIIVNN-SEMNGIRNAARASVE 453
            |||..|::::.||||.:|||:...|...|:|:....||.|.||.|:... .:.|..|..||.|:.
Worm   387 MAASTIILSNDSGGPRMDIVKDYEGHCVGYLSITKEEYVETILKIVEEGLKKRNDTRKYARKSLT 451

  Fly   454 RFSEQEFEKNFLRAV 468
            ||.|..||.::.:.:
Worm   452 RFGEAAFETHWNKEI 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg11	NP_001262182.1	PLN02949	24..473	CDD:215511	188/454 (41%)
Alg11	NP_001262182.1	GT1_ALG11_like	44..463	CDD:99978	185/427 (43%)
algn-11	NP_498606.1	PLN02949	8..458	CDD:215511	189/460 (41%)
algn-11	NP_498606.1	GT1_ALG11_like	41..461	CDD:99978	186/436 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167934
Domainoid	1	1.000	210	1.000	Domainoid score	I1646
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68893
Inparanoid	1	1.050	351	1.000	Inparanoid score	I1336
Isobase	1	0.950	-	0	Normalized mean entropy	S1546
OMA	1	1.010	-	-		QHG53627
OrthoDB	1	1.010	-	-		D1051021at2759
OrthoFinder	1	1.000	-	-		FOG0004723
OrthoInspector	1	1.000	-	-		oto20230
orthoMCL	1	0.900	-	-		OOG6_101910
Panther	1	1.100	-	-	LDO	PTHR45919
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R38
SonicParanoid	1	1.000	-	-		X3321
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790