DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7166 and SIGLEC6

DIOPT Version :9

Sequence 1:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_011525835.1	Gene:	SIGLEC6 / 946	HGNCID:	10875	Length:	464	Species:	Homo sapiens

Alignment Length:	356	Identity:	76/356 - (21%)
Similarity:	123/356 - (34%)	Gaps:	94/356 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SLSLIGGSFILPENDPPTTAPKFLSRGHLYKVIVGETIEL-------PCKVQNLGSFVLLWRKGS 76
            ||::..|..:|.....|||.|... .|:.|..:.|..:.:       ..:.:..|.|.|||
Human    38 SLTVQEGLCVLVPCRLPTTLPASY-YGYGYWFLEGADVPVATNDPDEEVQEETRGRFHLLW---- 97

  Fly    77 SVLTAGHLKITRDQRFKIVGDYNLQINGVKTQDAGDYICQL-------GDQENRDQV------HT 128
                        |.|.|   :.:|.|...:.:|...|..:|       |...::..|      |.
Human    98 ------------DPRRK---NCSLSIRDARRRDNAAYFFRLKSKWMKYGYTSSKLSVRVMALTHR 147

  Fly   129 VEILVPPTLRALPHNGQVTARKGSTVTLECKASGNPVPTIFWFKKDVFSGPTHL----SDSSTLI 189
            ..|.:|.||.: .|...:|.    :|...|: .|.| |...|..    :.||.|    :.||.|.
Human   148 PNISIPGTLES-GHPSNLTC----SVPWVCE-QGTP-PIFSWMS----AAPTSLGPRTTQSSVLT 201

  Fly   190 LENVDRHHAGTYQCSAD-NGVKDRVSMDIQLTI--------LSPPE------------------I 227
            :....:.|:....|... .|....:...|||.:        ||.|:                  |
Human   202 ITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSWMLRRPPLSTPDAPQKVAISIFQGNSAAFKI 266

  Fly   228 TVEKSWVHASEGYDVELVCIVHGDVNSEMLWYQNSFLLDATDRRSMYPRDDRYSLIIRNFQPTDF 292
            ....|.:...||..:.|:|...|:..:.:.|:|....|:||      |..:...|.:......:.
Human   267 LQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNAT------PISNTGVLELPQVGSAEE 325

  Fly   293 GNYSCVADNALGRTKKYIEV------SGRPG 317
            |:::|.|.:.||..:..:.:      .||.|
Human   326 GDFTCRAQHPLGSLQISLSLFVHWKPEGRAG 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	18/102 (18%)
		Ig	56..116	CDD:143165	12/66 (18%)
		IG_like	144..221	CDD:214653	19/81 (23%)
		IGc2	151..209	CDD:197706	14/62 (23%)
		IG_like	232..313	CDD:214653	18/86 (21%)
		Ig	242..311	CDD:143165	15/68 (22%)
SIGLEC6	XP_011525835.1	Ig	31..141	CDD:299845	26/122 (21%)
		IG_like	36..141	CDD:214653	26/122 (21%)
		Ig_3	147..218	CDD:290638	20/81 (25%)
		I-set	265..347	CDD:254352	19/87 (22%)
		Ig	277..347	CDD:299845	17/75 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910