DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7166 and SIGLEC12

DIOPT Version :9

Sequence 1:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_443729.1	Gene:	SIGLEC12 / 89858	HGNCID:	15482	Length:	595	Species:	Homo sapiens

Alignment Length:	343	Identity:	76/343 - (22%)
Similarity:	127/343 - (37%)	Gaps:	89/343 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TTAPKFLSRGHLYKVIVGET--------IELPCKV-----------QNLGSFVLLWRKGSSV--- 78
            |.:...|||   |::.|.|:        :.:||.|           ...||:   :::|:.:
Human   142 TASQDLLSR---YRLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSW---FKEGADIPWD 200

  Fly    79 ------LTAGHLKITRDQRFKIVGD-----YNLQINGVKTQDAGDYICQL--GDQE-----NRDQ 125
                  ..:|.::.....||.::||     .:|.|...:..|:|.|..|:  |.::     ::..
Human   201 IPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLS 265

  Fly   126 VHTVEILVPPTLRALPHNGQVTARKGSTVTLECKA-----SGNPVPTIFWFKKDVFSGPTHLSDS 185
            ||...:...||. ::|.    |...|....|.|..     .|.| |||.|....|.|....::.|
Human   266 VHVTALTHMPTF-SIPG----TLESGHPRNLTCSVPWACEQGTP-PTITWMGASVSSLDPTITRS 324

  Fly   186 STLILENVDRHHAGTYQCSAD-NGVKDRVSMDIQLTILSPPE---ITV------------EKSWV 234
            |.|.|....:.|..:..|... .|....::..::|.|..||:   :||            ..|.:
Human   325 SMLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSAL 389

  Fly   235 HASEGYDVELVCIVHGDVNSEMLWYQNSFLLDATDRRSM----YPRDDRYSLIIRNFQPTDFGNY 295
            ...||..:.|||.|..:..:.:.|...|..|..:...::    .||          ....|.|.:
Human   390 SVLEGQSLHLVCAVDSNPPARLSWTWGSLTLSPSQSSNLGVLELPR----------VHVKDEGEF 444

  Fly   296 SCVADNALGRTKKYIEVS 313
            :|.|.|.||  .::|.:|
Human   445 TCRAQNPLG--SQHISLS 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	22/122 (18%)
		Ig	56..116	CDD:143165	16/84 (19%)
		IG_like	144..221	CDD:214653	20/82 (24%)
		IGc2	151..209	CDD:197706	17/63 (27%)
		IG_like	232..313	CDD:214653	20/84 (24%)
		Ig	242..311	CDD:143165	16/72 (22%)
SIGLEC12	NP_443729.1	Ig	24..142	CDD:325142	76/343 (22%)
		Ig	151..269	CDD:325142	23/120 (19%)
		Ig	232..345	CDD:325142	30/118 (25%)
		IG_like	389..462	CDD:214653	20/84 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..560
		ITIM motif	563..568
		SLAM-like motif	586..591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910