DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7166 and Robo1

DIOPT Version :9

Sequence 1:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_017453545.1	Gene:	Robo1 / 58946	RGDID:	61941	Length:	1687	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	121/510 - (23%)
Similarity:	190/510 - (37%)	Gaps:	126/510 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTYTRKYWTLVLYLFSFSLSLIG-----GSFILPENDPPTT------APKFLSRGHLYKVIVGE 54
            |.|||||             |..|     |:.::.|.:....      .|.|:.|.....|.|.:
  Rat   259 MITYTRK-------------SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDD 310

  Fly    55 TIELPCKVQNLGSFVLLWRKGSSVLTAGHLKITRDQRFKIVGDYNLQINGVKTQDAGDYICQLGD 119
            :.|..|:.:......:.|||....|.        ..|::|..|:.|:|..|...|.|.|.|...:
  Rat   311 SAEFKCEARGDPVPTVRWRKDDGELP--------KSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN 367

  Fly   120 QENRDQVH---TVEI-LVPPTLRALPHNGQVTARKGSTVTLECKASGNPVPTIFW---------- 170
            ...:.:..   ||:: ..||.....|.: ||.| .|.|||.:|:|:|||.|.|||
  Rat   368 MVGKAEASATLTVQVGSEPPHFVVKPRD-QVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLF 430

  Fly   171 -FKKDVFSGPTHLSDSSTLILENVDRHHAGTYQCSADN---GVKDRVSMDIQLTILSPPEITVEK 231
             ::....|....:|.:..|.:.||.|...|.|.|...|   .:..:..:::...|...|...:.:
  Rat   431 SYQPPQSSSRFSVSQTGDLTVTNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ 495

  Fly   232 SWVHASEGYD--VELVCIVHGDVNSEMLWYQNSFLLDATDRRSMYPRDDRYSLIIRNFQPTDFGN 294
            ..|:.:...|  :.|.|:..|.....:||.::..|:...|.|  ..:.:...|.||..:..|.|.
  Rat   496 GPVNQTVAVDGTLTLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLESGVLQIRYAKLGDTGR 558

  Fly   295 YSCVADNALGRT--KKYIEVS------GRPGPADFISPALSGFLDHYNLTWTIESIPPLDEIK-- 349
            |:|.|....|..  ..||||.      ..|.|.|   |         ||..:..|.|.:.::.
  Rat   559 YTCTASTPSGEATWSAYIEVQEFGVPVQPPRPTD---P---------NLIPSAPSKPEVTDVSKN 611

  Fly   350 ---LLYRRLLMN---------ETYQHP--GKWHEYHIKPTPIRTDGSHFLMSYLVKNLEHNAVYE 400
               ||::..|.:         |.:.|.  ..|...   ...::|:      ::.:|.|:.||:|.
  Rat   612 TVTLLWQPNLNSGATPTSYIIEAFSHASGSSWQTV---AENVKTE------TFAIKGLKPNAIYL 667

  Fly   401 AIVQAKNKYGWNEISDIHQFYTRNHDLLLDIDMEYKMGISSNIR---ISPTVSGI 452
            .:|:|.|.||   |||..|                   ||..::   :.||..|:
  Rat   668 FLVRAANAYG---ISDPSQ-------------------ISDPVKTQDVPPTTQGV 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	20/86 (23%)
		Ig	56..116	CDD:143165	15/59 (25%)
		IG_like	144..221	CDD:214653	26/90 (29%)
		IGc2	151..209	CDD:197706	23/71 (32%)
		IG_like	232..313	CDD:214653	22/84 (26%)
		Ig	242..311	CDD:143165	18/70 (26%)
Robo1	XP_017453545.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000