DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7166 and IGSF9

DIOPT Version :9

Sequence 1:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens

Alignment Length:	341	Identity:	85/341 - (24%)
Similarity:	134/341 - (39%)	Gaps:	82/341 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WTLVLYLFSFSLS----------------------LIGGSFILPENDPPTTAPKFLSRGHLYKVI 51
            |.|.|.:.|..:|                      ::|...:.|...||....::|..|.|..:.
Human     3 WCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIF 67

  Fly    52 VGETIELPCKVQNLGSFVLLWRKGSSVLTAGHLKITRDQ--RFKIVGDYNLQINGVKTQDAGDYI 114
            :...:..|                         :|..|.  |.::....:|||.|::.:|.|.|.
Human    68 IQFGLYSP-------------------------RIDPDYVGRVRLQKGASLQIEGLRVEDQGWYE 107

  Fly   115 CQL---------GDQENRDQVHTVEILVPPTLRALPHNGQVTARKGSTVTLECKASGNPVPTIFW 170
            |::         .|..|...|| :.:..||..:..| ...:..::...|||.|.|.|:|:|.:.|
Human   108 CRVFFLDQHIPEDDFANGSWVH-LTVNSPPQFQETP-PAVLEVQELEPVTLRCVARGSPLPHVTW 170

  Fly   171 --FKKDVFSGPTHLS-DSSTLILENVDRHHAGTYQCSADNGVKDRVSMDIQLTILSPPEITV--E 230
              ..||:..|...:. .:.||.:..|:|..:|.|.|.| :..:...:...||.:|.||.|.|  :
Human   171 KLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQA-SSTEGSATHATQLLVLGPPVIVVPPK 234

  Fly   231 KSWVHASEGYDVELVCIVHGD---VNSEMLWYQNSFLLDATDRRSMYPR-----DDRYSLIIRNF 287
            .|.|:||:  ||.|.|  |.:   .|....|:|::..:....|  :.||     |.  ||.:...
Human   235 NSTVNASQ--DVSLAC--HAEAYPANLTYSWFQDNINVFHISR--LQPRVRILVDG--SLRLLAT 291

  Fly   288 QPTDFGNYSCVADNAL 303
            ||.|.|.|:||..|.|
Human   292 QPDDAGCYTCVPSNGL 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	16/93 (17%)
		Ig	56..116	CDD:143165	11/61 (18%)
		IG_like	144..221	CDD:214653	22/79 (28%)
		IGc2	151..209	CDD:197706	20/60 (33%)
		IG_like	232..313	CDD:214653	27/80 (34%)
		Ig	242..311	CDD:143165	22/70 (31%)
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	23/133 (17%)
		IG_like	28..110	CDD:214653	19/106 (18%)
		I-set	136..223	CDD:254352	24/88 (27%)
		Ig	154..220	CDD:143165	20/66 (30%)
		Ig_3	226..305	CDD:290638	29/86 (34%)
		IG_like	233..319	CDD:214653	27/83 (33%)
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810