DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7166 and robo4

DIOPT Version :9

Sequence 1:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_689255.3	Gene:	robo4 / 560765	ZFINID:	ZDB-GENE-020809-1	Length:	1134	Species:	Danio rerio

Alignment Length:	212	Identity:	62/212 - (29%)
Similarity:	89/212 - (41%)	Gaps:	42/212 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 NRDQVH-------TVEILVPPTLRALPHNGQVTARKGSTVTLECKASGNPVPTIFWF-------- 171
            :||:.|       ..||.:|   |.:.|...|..|.||..||.|:|.|||.|||.|.
Zfish    52 HRDRAHRRKGSRLVSEINLP---RIVHHPSDVVVRVGSPATLSCRAEGNPEPTIQWLRNGQPLDT 113

  Fly   172 -KKDVFSGPTHLSDSSTLILENV----DRHHAGTYQCSADNGVKDRVSMDIQLTILSPPE-ITVE 230
             |.|..|.|..|.|.|......|    .:.|...|.|.|.|.:.:..|.:..|.|.:..| ..|:
Zfish   114 DKMDAQSQPIVLPDGSLFFFSVVPGRKGQSHEAVYACIAHNSIGNATSRNASLHIAALREDFRVQ 178

  Fly   231 KSWVHASEGYDVELVC---IVHGDVNSEMLWYQNSFLLDATDRRSMYPRDDRYS-----LIIRNF 287
            .|.|..:.|....:.|   :.|.:.|  :.|.::..|::::        ::.|:     |||...
Zfish   179 PSDVEVAIGEMATINCSPPVGHPEPN--VTWRKDGILINSS--------NEHYTELKGKLIIAPA 233

  Fly   288 QPTDFGNYSCVADNALG 304
            |..|.|.|||:|.|.:|
Zfish   234 QKNDSGVYSCIASNMIG 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	5/17 (29%)
		Ig	56..116	CDD:143165
		IG_like	144..221	CDD:214653	30/89 (34%)
		IGc2	151..209	CDD:197706	26/70 (37%)
		IG_like	232..313	CDD:214653	21/81 (26%)
		Ig	242..311	CDD:143165	18/71 (25%)
robo4	XP_689255.3	Ig1_Robo	70..169	CDD:143317	33/101 (33%)
		I-set	71..168	CDD:254352	33/99 (33%)
		I-set	175..261	CDD:254352	22/86 (26%)
		Ig2_Robo	177..261	CDD:143201	22/84 (26%)
		I-set	265..350	CDD:254352
		Ig	282..350	CDD:299845
		FN3	373..448	CDD:214495
		FN3	472..560	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900