DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7166 and LRIT3

DIOPT Version :9

Sequence 1:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_940908.3	Gene:	LRIT3 / 345193	HGNCID:	24783	Length:	679	Species:	Homo sapiens

Alignment Length:	324	Identity:	75/324 - (23%)
Similarity:	118/324 - (36%)	Gaps:	95/324 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 QVTARKGSTVTLECKASGNPVPTIFWFKKDVFSGP---THLSDS-------STLILENVDRHHAG 199
            ::.:..||.|.|.|.|:|.|.|.|.|.:.|  |.|   |.:.:|       |.:.|..:....||
Human   262 KIMSALGSNVLLRCDATGFPTPQITWTRSD--SSPVNYTVIQESPEEGVRWSIMSLTGISSKDAG 324

  Fly   200 TYQCSADN--GVKDRVSMDIQLTILS------PPEITVEKSWVHASEGYDVELVCIVHGDVNSEM 256
            .|:|.|.|  |:.:.|   :.:|:|.      ||: |.|::..|..  :||:     .|...|..
Human   325 DYKCKAKNLAGMSEAV---VTVTVLGITTTPIPPD-TSERTGDHPE--WDVQ-----PGSGRSTS 378

  Fly   257 LWYQNSFLLDATDRRSMYPRDDRYSLIIRNFQPTDFGNYSCVADNALGRTKKYIEVSGRPGPADF 321
            :...:|:|..:                  :|.||...:.|.::.               |..|.|
Human   379 VSSASSYLWSS------------------SFSPTSSFSASTLSP---------------PSTASF 410

  Fly   322 -ISPALSGFLDHYNLTWTIESIPPLDEIKLLYRRLLMNETYQ-HPGKWHEYHI-----KPTPIRT 379
             :||..|.         |:.|...|.........:....::| |.|......:     |..|..|
Human   411 SLSPFSSS---------TVSSTTTLSTSISASTTMANKRSFQLHQGGKRNLKVAKNGSKLPPAST 466

  Fly   380 DGSHFLMSYLVKNL--EHNAVYEAI-VQAKNKYG----WNEISDIHQ-----FYTR--NHDLLL 429
            .....| :.|.:.:  |.||..|.: |.::.|..    ||.|:..|.     .|::  ..||||
Human   467 SKKEEL-ALLDQTMLTETNAAIENLRVVSETKESVTLTWNMINTTHNSAVTVLYSKYGGKDLLL 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653
		Ig	56..116	CDD:143165
		IG_like	144..221	CDD:214653	26/87 (30%)
		IGc2	151..209	CDD:197706	24/69 (35%)
		IG_like	232..313	CDD:214653	11/80 (14%)
		Ig	242..311	CDD:143165	9/68 (13%)
LRIT3	NP_940908.3	LRR 1	56..79
		leucine-rich repeat	59..82	CDD:275378
		LRR_8	61..117	CDD:290566
		LRR 2	80..103
		leucine-rich repeat	83..106	CDD:275378
		LRR 3	104..128
		LRR_8	105..165	CDD:290566
		LRR_4	105..146	CDD:289563
		leucine-rich repeat	107..130	CDD:275378
		LRR 4	129..151
		LRR_4	131..170	CDD:289563
		leucine-rich repeat	131..154	CDD:275378
		LRR 5	152..175
		leucine-rich repeat	155..168	CDD:275378
		Ig	267..345	CDD:299845	26/82 (32%)
		IG_like	267..345	CDD:214653	26/82 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..375		8/31 (26%)
		FN3	486..550	CDD:214495	12/44 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900