DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7166 and Ncam2

DIOPT Version :9

Sequence 1:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_981954.2	Gene:	Ncam2 / 288280	RGDID:	1303131	Length:	837	Species:	Rattus norvegicus

Alignment Length:	477	Identity:	109/477 - (22%)
Similarity:	175/477 - (36%)	Gaps:	124/477 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 GETIELPCKVQNLGSFVLLWRKGSSVLTAGHLKITRDQRFKIVGDYNLQINGVKTQDAGDYICQL 117
            ||..|:.|:|.:..:..:.|...:..:|.     ..|.||.::.:.||||..:...|.|.|.|:
  Rat   129 GEDAEVVCRVSSSPAPAVSWLYHNEEVTT-----IPDNRFAVLANNNLQILNINKSDEGIYRCE- 187

  Fly   118 GDQENRDQVHTVEIL----VPPTLRALPHNGQVTARKGSTVTLECKASGNPVPTIFWFK------ 172
            |..|.|.::...:|:    |||.:.....:...||.:|..:||.|||||:|.|.|.||:
  Rat   188 GRVEARGEIDFRDIIVIVNVPPAIVMPQKSFNATAERGEEMTLTCKASGSPDPAISWFRNGKLIE 252

  Fly   173 ---KDVFSGPTHLSDSSTLILENVDRHHAGTYQCSADNGV-KDRVSMDIQLTILSPPEITVEKSW 233
               |.:..|     .::.|.:.|:.....|:|.|.|.|.. :|:....:|:.:  .|.|...|:.
  Rat   253 ENEKYILKG-----SNTELTVRNIINKDGGSYVCKATNKAGEDQKQAFLQVFV--QPHILQLKNE 310

  Fly   234 VHASEGYDVELVCIVHGDVNSEMLWYQNSFLLDAT----------DRRSMYPRDDRYSLIIRNFQ 288
            ..:..|: |.|:|...|:...|:.|.:   .:|..          .|..:..:..|.||.||:.:
  Rat   311 TTSENGH-VTLICEAEGEPVPEITWKR---AIDGVTFSEGDKSPDGRIEVKGQHGRSSLHIRDVK 371

  Fly   289 PTDFGNYSCVADNALGRTKK------------------YIEVSGRP----------GPADF---- 321
            .:|.|.|.|.|.:.:|..::                  |....|.|          .||..
  Rat   372 LSDSGRYDCEAASRIGGHQRSMHLDIEYAPKFVSNQTMYYSWEGNPINISCDVKANPPASIHWRR 436

  Fly   322 -------------------------ISPALSGFLDHYNLTWT----------------IESIP-- 343
                                     |:|........||.|.|                :.|.|
  Rat   437 EKLVLPAKNTTHLKTHSVGRKMILEIAPTSDNDFGRYNCTATNRIGTRFQEYILELADVPSSPRG 501

  Fly   344 -PLDEIKLLYRRLLMNETYQHPG-KWHEYHIKPTPIRTD-----GSHFLMSYLV-KNLEHNAVYE 400
             .:.|:.....::..|:...|.| ..|.|.:....:.::     .||.:.:.:| .:||.|..||
  Rat   502 VKIIELSQTTAKISFNKPESHGGVPIHHYQVDVKEVTSETWKIVRSHGVQTTVVLSSLEPNTTYE 566

  Fly   401 AIVQAKNKYGWNEISDIHQFYT 422
            ..|.|.|..|..:.|.|..|.|
  Rat   567 VRVAAVNGKGQGDYSKIEIFQT 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	22/83 (27%)
		Ig	56..116	CDD:143165	15/59 (25%)
		IG_like	144..221	CDD:214653	26/86 (30%)
		IGc2	151..209	CDD:197706	22/66 (33%)
		IG_like	232..313	CDD:214653	21/108 (19%)
		Ig	242..311	CDD:143165	20/96 (21%)
Ncam2	NP_981954.2	IgI_1_NCAM-2	21..113	CDD:409452
		Ig strand B	38..42	CDD:409452
		Ig strand C	50..54	CDD:409452
		Ig strand E	76..80	CDD:409452
		Ig strand F	90..95	CDD:409452
		Ig strand G	104..107	CDD:409452
		IGc2	128..189	CDD:197706	18/65 (28%)
		Ig strand B	130..139	CDD:409353	3/8 (38%)
		Ig strand C	145..153	CDD:409353	1/7 (14%)
		Ig strand C'	156..159	CDD:409353	1/7 (14%)
		Ig strand D	162..167	CDD:409353	2/4 (50%)
		Ig strand E	168..175	CDD:409353	4/6 (67%)
		IgI_1_MuSK	209..298	CDD:409562	26/93 (28%)
		Ig strand B	228..232	CDD:409562	2/3 (67%)
		Ig strand C	241..245	CDD:409562	1/3 (33%)
		Ig strand E	264..268	CDD:409562	1/3 (33%)
		Ig strand F	278..283	CDD:409562	2/4 (50%)
		Ig strand G	291..294	CDD:409562	0/2 (0%)
		Ig	300..397	CDD:416386	23/102 (23%)
		Ig strand A	300..305	CDD:409353	1/6 (17%)
		Ig strand A'	309..313	CDD:409353	0/3 (0%)
		Ig strand B	317..325	CDD:409353	3/8 (38%)
		Ig strand C	331..337	CDD:409353	2/8 (25%)
		Ig strand C'	340..343	CDD:409353	0/2 (0%)
		Ig strand D	353..359	CDD:409353	1/5 (20%)
		Ig strand E	362..368	CDD:409353	3/5 (60%)
		Ig strand F	376..384	CDD:409353	4/7 (57%)
		Ig strand G	387..397	CDD:409353	1/9 (11%)
		Ig_3	401..479	CDD:404760	10/77 (13%)
		Ig strand B	418..422	CDD:409353	0/3 (0%)
		Ig strand C	431..435	CDD:409353	0/3 (0%)
		Ig strand E	458..462	CDD:409353	0/3 (0%)
		Ig strand F	472..477	CDD:409353	2/4 (50%)
		Ig strand G	486..489	CDD:409353	0/2 (0%)
		FN3	496..588	CDD:238020	23/91 (25%)
		fn3	594..678	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810