DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7166 and Ncam1

DIOPT Version :9

Sequence 1:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_038936733.1	Gene:	Ncam1 / 24586	RGDID:	67378	Length:	1136	Species:	Rattus norvegicus

Alignment Length:	636	Identity:	132/636 - (20%)
Similarity:	218/636 - (34%)	Gaps:	251/636 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 GETIELPCKVQNLGSFVLLWR-KGSSVLTAGHLKITRDQRFKIVGDYNLQINGVKTQDAGDYICQ 116
            ||...:.|.|.:.....::|: ||..|:      :.:|.||.::.:..|||.|:|..|.|.|.|:
  Rat   132 GEDAVIVCDVVSSLPPTIIWKHKGRDVI------LKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190

  Fly   117 LGDQENRDQVH----TVEILVPPTLRALPHNGQVTARKGSTVTLECKASGNPVPTIFWFK----- 172
             |....|.:::    .|.:.||||::|.......||..|.:|||.|.|.|.|.||:.|.|
  Rat   191 -GRILARGEINFKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEPI 254

  Fly   173 --------KDVFSGPTHLSDSSTLILENVDRHHAGTYQCSADN--GVKDRVSMDIQLTILSPPEI 227
                    |.:||     .|||.|.:.|||::....|.|.|:|  |.:|   ..|.|.:.:.|:|
  Rat   255 ENEEEDDEKHIFS-----DDSSELTIRNVDKNDEAEYVCIAENKAGEQD---ASIHLKVFAKPKI 311

  Fly   228 TVEKSWVHASEGYDVELVCIVHGDVNSEMLWYQNSFLLDATDRRSMYPRDDRY------------ 280
            |..::.........|.|.|...||....:.|..::..:.:.::.| :.|.::.
  Rat   312 TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKAS-WTRPEKQETLDGHMVVRSH 375

  Fly   281 ----SLIIRNFQPTDFGNYSCVADNALGRTKK--YIEVSGRP---GPA----------------- 319
                ||.:::.|.||.|.|.|.|.|.:|:..:  |:||...|   ||.
  Rat   376 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVF 440

  Fly   320 DFISPALSGFLD----------------------------------HYNLT-------WTIE--- 340
            .:.|..:|.|.|                                  :||.|       .::|
  Rat   441 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 505

  Fly   341 ------SIPPLDEIK---------------------LLYR---RLLMNETYQHPGKWHE------ 369
                  |.|.:|.::                     |.|:   :.|..|.:.  .||::
  Rat   506 VQADTPSSPSIDRVEPYSSTAQVQFDEPEATGGVPILKYKAEWKSLGEEAWH--SKWYDAKEANM 568

  Fly   370 --------------YHI-------------------KPTPIRT------------------DGS- 382
                          |.:                   |..|:.:                  ||:
  Rat   569 EGIVTIMGLKPETRYAVRLAALNGKGLGEISAATEFKTQPVHSPPPQGEPSAPKLEGQMGEDGNS 633

  Fly   383 ----------------HFLMSY---------------------LVKNLEHNAVYEAIVQAKNKYG 410
                            |:|:.|                     ::|:|:.||.||..|.|:|:.|
  Rat   634 IKVNLIKQDDGGSPIRHYLVKYRAKLASEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 698

  Fly   411 WNEISDIHQFYTRNHDLLLDIDMEYKMGISSNIRISPTVSGIILSAFILVL 461
            .::.:.. .|.|......:..:.....|:|:.     .:.||::..|:|:|
  Rat   699 KSKAAHF-VFRTSAQPTAIPANGSPTAGLSTG-----AIVGILIVIFVLLL 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	23/84 (27%)
		Ig	56..116	CDD:143165	17/60 (28%)
		IG_like	144..221	CDD:214653	32/91 (35%)
		IGc2	151..209	CDD:197706	26/72 (36%)
		IG_like	232..313	CDD:214653	21/98 (21%)
		Ig	242..311	CDD:143165	20/86 (23%)
Ncam1	XP_038936733.1	IgI_1_NCAM-1	20..116	CDD:409451
		Ig strand B	37..41	CDD:409451
		Ig strand C	51..55	CDD:409451
		Ig strand E	79..83	CDD:409451
		Ig strand F	93..98	CDD:409451
		Ig strand G	107..110	CDD:409451
		IG_like	124..190	CDD:214653	19/63 (30%)
		Ig strand B	135..139	CDD:409353	0/3 (0%)
		Ig strand C	148..152	CDD:409353	0/3 (0%)
		Ig strand E	172..176	CDD:409353	1/3 (33%)
		Ig strand F	186..191	CDD:409353	2/5 (40%)
		IgI_3_NCAM-1	211..308	CDD:143207	36/104 (35%)
		Ig strand B	231..235	CDD:143207	3/3 (100%)
		Ig strand C	244..248	CDD:143207	1/3 (33%)
		Ig strand E	271..275	CDD:143207	2/3 (67%)
		Ig strand F	285..290	CDD:143207	2/4 (50%)
		Ig strand G	298..301	CDD:143207	1/5 (20%)
		IgI_NCAM-1	307..413	CDD:143277	23/106 (22%)
		Ig strand B	326..330	CDD:143277	2/3 (67%)
		Ig strand C	339..343	CDD:143277	0/3 (0%)
		Ig strand E	379..383	CDD:143277	2/3 (67%)
		Ig strand F	393..398	CDD:143277	2/4 (50%)
		Ig strand G	406..409	CDD:143277	0/2 (0%)
		Ig_3	422..494	CDD:404760	8/71 (11%)
		Ig strand B	433..437	CDD:409353	0/3 (0%)
		Ig strand C	446..450	CDD:409353	1/3 (33%)
		Ig strand E	473..477	CDD:409353	0/3 (0%)
		Ig strand F	487..492	CDD:409353	2/4 (50%)
		FN3	509..606	CDD:238020	10/98 (10%)
		fn3	619..701	CDD:394996	15/81 (19%)
		Herpes_BLLF1	<842..1133	CDD:282904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810